Lanthanide ions inhibit the activity of dihydrofolate reductase from chicken liver

BioMetals

Volumn 13, Issue 3, 2000, Pages 195-201

  Wu, Y ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

DHFR; Enzyme activation; Enzyme inhibition; Fluorescence probe; Lanthanide elements

Indexed keywords

CALCIUM ION; DIHYDROFOLATE REDUCTASE; EUROPIUM; POTASSIUM ION; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM ION;

ANIMAL TISSUE; ARTICLE; CHICKEN; CONTROLLED STUDY; ENERGY TRANSFER; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PURIFICATION; FLUORESCENCE; LIVER; LUMINESCENCE; NONHUMAN;

ANIMALS; CATIONS, DIVALENT; CATIONS, MONOVALENT; CHICKENS; ENERGY TRANSFER; ENZYME ACTIVATION; EUROPIUM; FOLIC ACID ANTAGONISTS; KINETICS; LIVER; LUMINESCENT MEASUREMENTS; METALS, RARE EARTH; POTASSIUM CHLORIDE; SODIUM CHLORIDE; SPECTROMETRY, FLUORESCENCE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0033710739     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009220311261     Document Type: Article

References (32)

1. The location of the lanthanide ion binding site on bovine trypsin
2. Inhibition of dihydrofolate reductase: Effect of reduced nicotinamide adenine dinucleotide phosphate on the selectivity and affinity of diaminobenzylpyrimidines
3. Chicken liver dihydrofolate reductase: Activation and alteration of enzymatic properties as a result of reaction with methylmercury
4. Spectroscopic studies of metal ion binding to a tryptophan-containing parvalbumin
5. Terbium (III) emission as a probe of calcium(II) binding sites in proteins
6. Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase
7. L1210 dihydrofolate reductase. Kinetics and mechanism of activation by various agents
8. Calcium binding site of trypsin as probed by lanthanides
9. Activation of chicken liver dihydrofolate reductase in concentrated urea solutions
10. Activation of dihydrofolic reductase by organic mercurials
11. Studies on dihydrofolic reductase. 3. Activation of the chicken liver enzyme by urea and thiourea
12. Methotrexate-agarose in the purification of dihydrofolate reductase
13. Characterization of chicken liver dihydrofolate reductase after purification by affinity chromatography and isoelectric focusing
14. Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization
15. Paramegnetic metal complexes as water proton relaxation agents for NMR imaging: Theory and design
16. Binding of lanthanide ions to thermolysin
17. + and biopterin
18. Characterization of lanthanide (III) ion binding to calmodulin using luminescence spectroscopy
19. Ion-dependent activation of dihydrofolate reductase from L1210 cells
20. Catalytic mechanism of the dihydrofolate reductase reaction as determined by pH studies
21. Kinetics of substrate reaction during irreversible modification of enzyme activity
22. Conformational flexibility of enzyme active sites
23. 3+
24. The effects of lanthanide ions and their complexes on the phase-transition property of dipalmitoylphophatidylethanolamine liposomes
25. Lanthanide ions assisted the tripe domain structure formation of phospholipid Langmuir-Blodgett film observed by atomic force microscopy
26. 2D NMR and FT-Raman spectroscopic studies on the interaction of lanthanide ions and Ln-DTPA with phospholipid bilayers