Hydroxyurea inhibition of cellular and developmental activities in the decidualized and pregnant uteri of rats

Journal of Applied Toxicology

Volumn 20, Issue 5, 2000, Pages 407-412

  Spencer, Fitzgerald ^a   Chi, Limen ^a   Zhu, Ming Xia ^a  

^a SOUTHERN UNIVERSITY   (United States)

Author keywords

Alkaline phosphatase; Decidualized; Estrogen; Hydroxyurea; Matrix metalloproteinase; mRNA; Nitric oxide synthase; Pregnant; Progesterone; Uteri

Indexed keywords

ALKALINE PHOSPHATASE; DNA; ESTROGEN RECEPTOR; HYDROXYUREA; MATRIX METALLOPROTEINASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PROGESTERONE;

ANIMAL TISSUE; ARTICLE; CYTOTOXICITY; DECIDUALIZATION; ENDOMETRIUM; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; MITOGENESIS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; RAT STRAIN;

ANIMALS; BLOTTING, WESTERN; DECIDUA; ENZYME INHIBITORS; FEMALE; HYDROXYUREA; MATRIX METALLOPROTEINASES; NITRIC OXIDE SYNTHASE; PREGNANCY; PSEUDOPREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEOTIDE REDUCTASES; RNA, MESSENGER; UTERUS;

EID: 0033709286     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1263(200009/10)20:5<407::AID-JAT704>3.0.CO;2-T     Document Type: Article

References (37)

1. Phase II trial of hydroxyurea, dicarbazine (DTIC) and etoposide (VP-16) in mixed mesodermal tumors of the uterus: A gynecologic oncology group study
2. Ifosfamide, adriamycin and cisplatin (IAP) plus bleomycin (B) combination chemotherapy in patients with recurrent cancer of the uterine cervix
3. Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors
4. Alkaline phosphatase activity is expressed only in B lymphocytes committed to proliferation
5. Fetal hemoglobin and F-cell responses to tong-term hydroxyurea treatment in young sickle cell patients. The French study group on sickle disease
6. Trimidox-mediated morphological changes during erythroid differentiation, associated with the stimulation of hemoglobin and F-cell production in human K-562 cells
7. Regression of extramedullary haemopoiesis and augumentation of fetal haemoglobin concentration during hydroxyurea therapy in beta thalassaemia
8. Cytokines and soluble adhesion molecules in sickle cell anemia patients during hydroxyurea therapy
9. Hydroxyurea therapy in thalassemia
10. Biochemical and antihumor activity of trimidox, a new inhibitor of ribonucleotide reductase
11. The nature of the embryo-protective interaction of propyl gallate with hydroxyurea
12. Effect of nucleotide analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells
13. Teratogenic drugs inhibit the differentiation of fetal rat limb buds grafted in athymic (nude) mice
14. D-mannitol, a specific hydroxyl free radical scavenger, reduces the development toxicity of hydroxyurea in rabbits
15. Confocal laser scanning microscopy of apoptosis in organogenesis-stage mouse embryos
16. Reaction of the mouse uterus during implantation and deciduoma formation as determined by changes in the distribution of alkaline phosphates
17. A pilot study of hydroxyurea among patients with advanced human immunodeficiency virus (HIV) disease receiving chronic didanosine therapy: Canadian HIV trials network protocol 080
18. Protein measurement with the folin phenol reagent
19. A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
20. The influence of fetectomy at midgestation upon the serum concentration of progesterone, estrone and estradiol in baboons
21. Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum
22. Gelatinase and proteoglycanase activity during the periovulatory period in the rat
23. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
24. Dual Expression of prolactin-related protein in decidua and trophoblast tissues during pregnancy in rats
25. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β
26. Control of uterine stromal mitosis in relation to uterine sensitivity and decidualization in mice
27. The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TG beta I, DNA damage and Fas
28. Hydroxxyurea for treatment of unrestricted meningiomas, II. Decrease in the size of meningiomas in patients treated with hydroxyurea
29. The cell cycle and induction of apoptosis in a hamster fibrosarcoma cell line treated with anti-cancer drugs; its importance to solid tumor chemotherapy
30. Nitric oxide in the human uterus
31. A nitric oxide system in the uterus: It regulates uterine contractility during pregnancy and labor and is modulated by steroid hormones
32. Identification of nitric oxide synthase in human uterus
33. L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relation
34. Matrix metalloproteinases and their inhibitors in connective tissue remodeling
35. Matrix metalloproteinase and matrix metalloproteinase inhibitor expression in endometrial stromal cell during progestin-initiated decidualization and menstruation-related progestin withdrawal
36. Expression of decidual prolactin-related protein in the rat decidua
37. The decidual prolactin protein receptor and its regulation by decidua-derived factors