An investigation of interactions between the immune system and stimulus-secretion coupling in mouse submandibular acinar cells. A possible mechanism to account for reduced salivary flow rates associated with the onset of Sjogren's syndrome

Rheumatology

Volumn 39, Issue 11, 2000, Pages 1226-1233

  Dawson, L J ^a   Christmas, S E ^a   Smith, P M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cholinesterase; Cytokines; Intracellular calcium; Signal transduction; Sjogren's syndrome

Indexed keywords

ACETYLCHOLINE; CALCIUM; CHOLINESTERASE; CONCANAVALIN A; CYTOKINE;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; EXPOSURE; FLOW RATE; IMMUNE SYSTEM; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MALE; MICROFLUOROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALIVATION; SJOEGREN SYNDROME; SPLEEN LYMPHOCYTE; STIMULUS RESPONSE; STIMULUS SECRETION COUPLING; SUBMANDIBULAR GLAND;

EID: 0033708288     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/39.11.1226     Document Type: Article

References (45)

1. Sjogren's syndrome. Proposed criteria for classification
2. The European Community Study Group on diagnostic criteria for Sjogren's syndrome. Sensitivity and specificity of tests for ocular and oral involvement in Sjogren's syndrome
3. Sjogren's syndrome
4. Predictors of lymphoma development in primary Sjogren's syndrome
5. What causes Sjogren's syndrome?
6. Review of UK data on the rheumatic diseases-2. Rheumatoid arthritis
7. The etiopathogenesis of Sjogren's syndrome
8. Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (CA2) in patients with rheumatoid arthritis
9. Sjogren's syndrome: Immunologic and neuroendocrine mechanisms
10. Pathogenesis and treatment of Sjogren's syndrome
11. Qualitative and quantitative observations on the histology of human labial salivary glands obtained post mortem
12. Unstimulated and stimulated parotid salivary flow rate in individuals of different ages
13. Is reduced salivary flow normal in old people?
14. Xerostomia: Diagnosis, management and clinical complications
15. An alternative perspective to the immune response in autoimmune exocrinopathy: Induction of functional quiescence rather than destructive autoaggression
16. A comparative quantitative histological investigation of atrophic changes in the major salivary glands of liquid fed rats
17. Intracellular calcium signalling in rat parotid cells that lack secretory vesicles
18. Morphological and functional characteristics of acinar atrophy and recovery in the duct-ligated parotid gland of rat
19. The effects of a liquid diet on initial and sustained, stimulated parotid salivary secretion and on parotid structure in the rat
20. Stimulus-secretion coupling: Cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells
21. Mechanisms of secretion by salivary glands
22. Single-blinded controlled trial of low-dose oral IFN-alpha for the treatment of xerostomia in patients with Sjogren's syndrome
23. Tumoricidal properties of mouse macrophages activated with mediators from rat lymphocytes stimulated with concanavalin A
24. Granulocyte-macrophage colony-stimulating factor is a major macrophage fusion factor present in conditioned medium of concanavalin A-stimulated spleen cell cultures
25. Differential activation requirements for virgin and memory T cells
26. Sex and parity modulate cytokine production during murine ageing
27. - Currents in mouse submandibular cells
28. Influence of culture conditions on the androgen control of secretory component production by acinar cells from the rat lacrimal gland
29. Collagen gel cultures of normal salivary gland: Conditions for continued proliferation and maintenance of major cell phenotypes in vitro
30. 2+ concentration by acetylcholine in acutely isolated mouse submandibular acinar cells
31. Electrolyte and fluid secretion in exocrine acinar cells
32. 2+ transport in lacrimal acinar cells
33. Cholinesterases in the blood of man
34. Analysis of the T-cell receptor Valpha repertoire and cytokine gene expression in Sjogren's syndrome
35. Chemokine expression and lymphocyte infiltration in Sjogren's syndrome
36. 2+ signalling
37. 2+ oscillations in pancreatic acinar cells. Spatiotemporal relationships and functional implications
38. Changes in the cholinergic system of lymphocytes due to mitogenic stimulation
39. Acetylcholinesterase activity of lymphocytes: An enzyme characteristic of T-cells
40. Release of membrane-bound enzymes from cells and the generation of isoforms
41. The innervation of normal human submandibular and parotid salivary glands. Demonstrated by cholinesterase histochemistry, catecholamine fluorescence and electron microscopy
42. The morphology of salivary glands
43. Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjogren syndrome: A randomized, placebo-controlled, fixed-dose, multicenter trial
44. Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjogren's syndrome
45. Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjogren's syndrome