Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: Involvement of CYP enzymes

Archives of Toxicology

Volumn 74, Issue 9, 2000, Pages 511-520

  Pellinen, P ^a   Kulmala, L ^b   Konttila, J ^b   Auriola, S ^b   Pasanen, M ^c   Juvonen, R ^b  

^a Santen Oy   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c NATIONAL AGENCY FOR MEDICINES   (Finland)

Author keywords

Cocaine; Cytochrome P450; Human liver; N Hydroxynorcocaine; Norcocaine

Indexed keywords

COCAINE; COUMARIN; CYTOCHROME P450; NORCOCAINE; PENTOXYRESORUFIN; TESTOSTERONE;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROXYLATION; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED DBA; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; SPECTROPHOTOMETRY, ULTRAVIOLET; STEROID 16-ALPHA-HYDROXYLASE;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0033695681     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000154     Document Type: Article

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