Characterization of an androgen-specific response region within the 5' flanking region of the murine epididymal retinoic acid binding protein gene

Biology of Reproduction

Volumn 63, Issue 6, 2000, Pages 1881-1892

  Lareyre, J J ^a   Reid, K ^a   Nelson, C ^a   Kasper, S ^a   Rennie, P S ^a   Orgebin Crist, M C ^a   Matusik, R J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Androgen receptor; Gene regulation; Sperm maturation

Indexed keywords

ANDROGEN; CIS ACTING ELEMENT; GLUCOCORTICOID; LIPOCALIN; RETINOIC ACID; RETINOIC ACID BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FLANKING REGION; EPIDIDYMIS; GENE EXPRESSION REGULATION; GENE LOCATION; GENETIC ANALYSIS; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PARACRINE SIGNALING; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECRETION;

ANIMALIA; CAPUT; MURINAE;

EID: 0033692368     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod63.6.1881     Document Type: Article

References (57)

1. Studies on the function of the epididymis
2. Specialized gene expression in the epididymis
3. Androgens and epididymal function
4. Gene expression in the epididymis
5. Differential patterns of regulated gene expression in the adult rat epididymis
6. Regulation of gamma-glutamyl transpeptidase catalytic activity and protein level in the initial segment of the rat epididymis by testicular factors: Role of basic fibroblast growth factor
7. Androgen and estrogen effects on protein synthesis by the adult rabbit epididymis
8. In vivo regulation of rat epididymal proteins by retinoids: Analysis by two-dimensional electrophoresis
9. Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis
10. The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid
11. Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid
12. Molecular cloning of cDNA for two major androgen dependent secretory proteins synthesized by rat epididymis
13. Presence of novel retinoic acid-binding proteins in the lumen of rat epididymis
14. X-ray crystallographic identification of a protein-binding site for both all-trans- and 9-cis-retinoic acid
15. Purification and crystallization of a retinoic acid-binding protein from rat epididymis. Identity with the major androgen-dependent epididymal proteins
16. Structure and expression of the rat epididymal secretory protein I gene. An androgen-regulated member of the lipocalin superfamily with a rare splice donor site
17. The lipocalin protein family: Structure and function
18. Genomic organization and chromosomal localization of the murine epididymal retinoic acid binding protein (mE-RABP) gene
19. The steroid and thyroid hormone receptor superfamily
20. The human androgen receptor: Complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate
21. Gene regulation by steroid hormones
22. Identification and characterization of a novel androgen response element composed of a direct repeat
23. The stringency and magnitude of androgen-specific gene activation are combinatorial functions of receptor and nonreceptor binding site sequences
24. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter
25. A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity
26. Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene
27. A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice
28. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
29. An efficient site-directed mutagenesis method based on PCR
30. The human androgen receptor: Domain structure, genomic organization and regulation of expression
31. Primary structure and expression of a functional human glucocorticoid receptor cDNA
32. Human chorionic somatomammotropin and growth hormone gene expression in rat pituitary tumour cells is dependent on proximal promoter sequences
33. A rapid and sensitive method for the quantitafion of microgram quantities of protein utilizing the principle of protein-dye binding
34. The relationship between glucocorticoid biopotency and receptor binding in the AtT-20 cell
35. A tyrosine aminotransferase glucocorticoid response element also mediates androgen enhancement of gene expression
36. Analysis of androgen receptor-DNA interactions with receptor proteins produced in insect cells
37. Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene
38. Androgen specificity of a response unit upstream of the human secretory component gene is mediated by differential receptor binding to an essential androgen response element
39. Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer
40. Response elements of the androgen-regulated C3 gene
41. Nuclear extracts enhance the interaction of fusion proteins containing the DNA-binding domain of the androgen and glucocorticoid receptor with androgen and glucocorticoid response elements
42. Nuclear extracts enhance gel retardation with androgen and glucocorticoid receptor DNA-binding domains
43. Functional characterization of an androgen response element in the first intron of the C3(1) gene of prostatic binding protein
44. Multiple components of a complex androgen-dependent enhancer
45. Many transcription factors interact synergistically with steroid receptors
46. Selective activation of the probasin androgen-responsive region by steroid hormones
47. Differential DNA binding by the androgen and glucocorticoid receptors involves the second Zn-finger and a C-terminal extension of the DNA-binding domains
48. Change of specificity mutations in androgen-selective enhancers. Evidence for a role of differential DNA binding by the androgen receptor
49. Androgen responsiveness of the murine beta-glucuronidase gene is associated with nuclease hypersensitivity, protein binding, and haplotype-specific sequence diversity within intron 9
50. Androgen modulation of DNA-binding factors in the mouse kidney
51. In vivo footprinting of an androgen-dependent enhancer reveals an accessory element integral to hormonal response
52. Nuclear receptor coactivators and corepressors
53. Steroid receptor induction of gene transcription: A two-step model
54. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells
55. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
56. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators