Coenzyme Q10 and its putative role in the ageing process

Protoplasma

Volumn 214, Issue 1-2, 2000, Pages 24-32

  Gingold, E B ^a   Kopsidas, G ^a   Linnane, A W ^a  

^a EPWORTH HOSPITAL   (Australia)

Author keywords

Ageing; Bioenergy; Coenzyme Q10; Mitochondria; Redox therapy

Indexed keywords

AGING; BIOENERGY; BIOLOGICAL FUNCTIONS; ELECTRON TRANSFER; MITOCHONDRIAL DNA; MOSAICISM; UBIQUINONE;

ANIMALIA;

EID: 0033679548     PISSN: 0033183X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02524259     Document Type: Review

References (51)

1. Sequence and organization of the human mitochondrial genome
2. Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA
3. Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies: An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy
4. The function of coenzyme Q in free radical production and as an antioxidant: A review
5. Coenzyme Q10 treatment in mitochondrial encephalomyopathies: Short-term double-blind, crossover study
6. Evidence for coenzyme Q function in Golgi membranes
7. Isolation of a quinone from beef heart mitochondria
8. Mitochondrial myopathy caused by long-term zidovudine therapy
9. Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts
10. 3 and C in a patient with a defect in electron transport at complex III in skeletal muscle
11. Antioxidant functions of coenzyme Q: Some functional and pathophysiological implications
12. Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria
13. 10) on muscular dystrophies and neurogenic atrophies
14. 10
15. 10
16. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
17. 10 during heart surgery
18. Coenzyme Q: Its role in scavenging and generation of radicals in membranes
19. Age-related changes in the lipid compositions of rat and human tissues
20. Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
21. Age associated bioenergy degradation: A definitive correlation between cellular bioenergy decline and extensive mtDNA rearrangements in human skeletal muscle
22. Method for in situ investigation of mitochondrial DNA deletions
23. Deltoid human muscle mtDNA is extensively rearranged in old age subjects
24. Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model
25. Usefulness of coenzyme Q10 in clinical cardiology: A long-term study
26. Treatment of essential hypertension with coenzyme Q10
27. 0 cells
28. The universality of bio-energetic disease: The role of mitochondrial mutation and the putative inter-relationship between mitochondria and plasma membrane NADH oxidoreductase
29. Coenzyme Q saturation kinetics of mitochondrial enzymes: Theory, experimental aspects and biomedical implications
30. Mitochondrial genetics in perspective: The derivation of a genetic and physical map of the yeast mitochondrial genome
31. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
32. Mitochondrial gene mutation: The ageing process and degenerative diseases
33. Mitochondrial DNA mutation and the ageing process: Bioenergy and pharmacological intervention
34. The universality of bioenergetic disease and amelioration with redox therapy
35. 10
36. 10 putatively acting through the plasma membrane oxidase
37. Possible molecular mechanisms of the protonmotive function of cytochrome systems
38. Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing: A cytochemical-immunohistochemical study
39. Mitochondrial DNA mutation associated with aging and degenerative disease
40. 10 treatment improves the tolerance of the senescent myocardium to pacing stress in the rat
41. Respiratory chain abnormalities in human disease
42. 10 deficiency
43. Evidence for coenzyme Q function in transplasma membrane electron transport
44. Requirement for coenzyme Q in plasma membrane electron transport
45. Some biochemical properties of human lymphoblastoid Namalwa cells grown anaerobically
46. Mitochondrial genetics: A paradigm for aging and degenerative diseases?
47. Mitochondrial DNA mutations in diseases of energy metabolism
48. Mitochondrial DNA alterations as ageing-associated molecular events
49. Coenzyme Q 1: Structure studies on the coenzyme Q group
50. Multiple mitochondrial DNA deletions in an elderly human individual
51. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans