Lessons learned from the past: A guide for the future of clinical pharmacology in the 21st century

Journal of Clinical Pharmacology

Volumn 40, Issue 9, 2000, Pages 946-966

  Lathers, C M ^a  

^a American College of Clinical Pharmacology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL PHARMACOLOGY; DRUG RESEARCH; HEALTH CARE ORGANIZATION; HISTORY OF MEDICINE; MEDICAL EDUCATION; REVIEW; TECHNOLOGY;

EID: 0033673837     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700022009684     Document Type: Review

References (30)

1. Pharmacokinetic and biopharmaceutic principles for clinical pharmacologists
2. Controversy I: Patients or healthy volunteers for pharmacokinetic studies
3. The basic concept: Clearance
4. Graphic methods in pharmacokinetics: The basics
5. Metabolic first-pass effects
6. Drug distribution and binding
7. Basic concepts in drug metabolism: Part I
8. Basic concepts in drug metabolism: Part II
9. In consideration of active metabolites
10. Controversy II: Bioequivalence as an indicator of therapeutic equivalence
11. Renal excretion
12. Biliary excretion
13. Drug absorption
14. Compartmental model analysis in pharmacokinetics
15. System approaches in pharmacokinetics: I. Basic concepts
16. System approaches in pharmacokinetics: II. Applications
17. Basic concepts in pharmacodynamic modeling
18. Application of statistical moment theory to pharmacokinetics
19. Physiological pharmacokinetic models
20. Pharmacokinetic/pharmacodynamic models
21. Controversy III: To model or not to model
22. Population pharmacokinetics
23. Controversy IV: Population pharmacokinetics, NONMEM and the pharmacokinetic screen
24. Bioavailability/bioequivalence: Study design and statistical issues
25. Pharmacokinetics of capacity-limited systems
26. Enterohepatic circulation of drugs
27. Disease states and drug pharmacokinetics
28. Implications of altered drug disposition in the elderly: Studies of benzodiazepines
29. New drugs: First time in man
30. Controversy V: First time in man studies