Applying evolutionary computation to understanding the insertion behavior of LINE-1 retrotransposons in human DNA

Proceedings of the IEEE Conference on Evolutionary Computation, ICEC

Volumn 2, Issue , 2000, Pages 836-843

  Meade, Andrew ^a   Corne, David ^a   Sibly, Richard ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EVOLUTIONARY COMPUTATION; BASIC PARAMETERS; GENETIC ELEMENTS; HUMAN GENOMES; INSERTION PROCESS; MOLECULAR LEVELS; NATURAL EVOLUTION; NUCLEOTIDE BASIS; RETROTRANSPOSON;

DNA; GENETIC ALGORITHMS; MATHEMATICAL MODELS; CALCULATIONS; GENES;

COMPUTATION THEORY; EVOLUTIONARY ALGORITHMS;

EID: 0033671886     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (12)

1. Davies, C.J. & Hutchison, C.A. (1995) "Insertion site specificity of the transposon Tn3" Nucleic Acids Research, 23: 507-514.
2. Doolittle, W.F. (1978) "Genes in pieces: Were they ever together?' Nature, 272: 581-582.
3. Fanning, T. & Singer, M. (1987) "The LINE-1 Elements in 4 Mammalian Orders Predicet Proteins that Conserve Homologies to Retrovirus Proteins" Nucleic Acids, E2251-2260.
4. Fogel, D.B., (1995). Evolutionary Computation: Towards a New Philosophy of Machine Intelligence. IEEE Press.
5. Gilbert, W. (1978) "Why genes in pieces?' Nature, 271:501
6. Goldberg, D.E., (1989). Genetic Algorithms in Search, Optimization & Machine Learning. Addison-Wesley.
7. Kazazian Jr, H.H. & Moran, J.V. (1998) "The impact of L1 retrotranspons on the human genome", Nature Genetics, 19: 19-24
8. Kimberland, Divoky, Prchal, Schwahn, Beger, Kazazian, "Full-length human L1 insertions retain the capacity for high frequency retrotranspoition in cultured cells", Human Molecular Genetics, 8 (8): 1557-1560.
9. Moran, J.V., DeBerardinis, R.J. & Kazazian Jr.m H.H. (1999) "Exon Shuffling by L1 Retrotransposition", Science, 283, pp. 1530-1534.
10. Rogers, J. (1985) "Exon shuffling and intron insertion in serine proteasegenes". Nature, 315:458-459.
11. Smith, T.F. & Waterman, M.S. (1981) "Identification of common molecular subsequences", Journal of Molecular Biology, 147, 195-197.
12. Syswerda, G. (1989) "Uniform crossover in Genetic Algorithms", in Schaffer, J.D. (ed.), Proceedings of the Third International Conference on Genetic Algorithms, Morgan Kaufmann, San Mateo, pp. 2-9.