The structure and oligomerization of the yeast arginine methyltransferase, Hmt1

Nature Structural Biology

Volumn 7, Issue 12, 2000, Pages 1165-1171

  Weiss, Valerie H ^a   McBride, Anne E ^a,b   Soriano, Michelle A ^a   Filman, David J ^a   Silver, Pamela A ^a,b   Hogle, James M ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ARGININE METHYLTRANSFERASE; DIMER; FUNGAL ENZYME; METHYLTRANSFERASE; PROTEIN HMT1; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SUBSTRATE; EUKARYOTE; GENE EXPRESSION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; BLOTTING, WESTERN; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA METHYLATION; ELECTROSTATICS; FUNGAL PROTEINS; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE DELETION;

EUKARYOTA;

EID: 0033669186     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/82028     Document Type: Article

References (26)

1. Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan pre-mRNA splicing factors
2. Identification of N(G)-methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif
3. Enzymic methylation of arginyl residues in -gly-arg-gly- peptides
4. The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase
5. A novel methyltransferase (Hmt1p) modifies poly(A)+ RNA binding proteins
6. Arginine methylation facilitates the nuclear export of hnRNP proteins
7. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)
8. Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation
9. A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor
10. Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3
11. PRMT3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation
12. Crystal structure of the conserved core of protein arginine methyltransferase PRMT3
13. Universal catalytic domain structure of AdoMet-dependent methyltransferases
14. Crystal structure of the chemotaxis receptor methyltransferase CheR suggests a conserved structural motif for binding S-adenosylmethionine
15. Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p and its in vivo function. Cofactor binding and substrate interactions
16. Processing of X-ray diffraction data collected in oscillation mode
17. Automated structure solution for MIR and MAD
18. The CCP4 suite: Programs for protein crystallography
19. Interactive computer graphics: FRODO
20. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
21. Raster3D photorealistic molecular graphics
22. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons