Effect of rate and inspiratory flow on ventilator-induced lung injury

Journal of Trauma - Injury, Infection and Critical Care

Volumn 49, Issue 5, 2000, Pages 903-911

  Rich, Preston B ^a   Reickert, Craig A ^a   Sawada, Shigeki ^a   Awad, Samir S ^a   Lynch, William R ^a   Johnson, Kent J ^a   Hirschl, Ronald B ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Artificial respiration; Barotrauma; Lung; Mechanical ventilators; Positive pressure ventilation; Respiratory insufficiency

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CONTROLLED STUDY; INSPIRATORY CAPACITY; LUNG COMPLIANCE; LUNG INJURY; LUNG WEIGHT; NEUTROPHIL; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; SHEEP; VENTILATOR;

EID: 0033665872     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-200011000-00019     Document Type: Article

References (30)

1. Mechanical ventilation at high airway pressures: Is it safe?
2. Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats
3. Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation
4. Increased microvascular permeability in dog lungs due to high peak airway pressures
5. ARDS: The non-homogeneous lung, facts and hypothesis
6. Pressure-volume curve of total respiratory system in acute respiratory failure
7. Barotrauma: Pathophysiology, risk factors, and prevention
8. Barotrauma and alveolar recruitment
9. Open up the lung and keep it open
10. Pressure control inverse ratio ventilation as a method to reduce peak inspiratory pressure and provide adequate ventilation and oxygenation
11. Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures: Protection by positive end-expiratory pressure
12. Role of tidal volume, FRC, and end-inspiratory pressure on the development of pulmonary edema following mechanical ventilation
13. Effects of partial liquid ventilation (PLV) on lung injury in a model of acute respiratory failure: A histologic and morphometric analysis
14. Correlative study of adult respiratory distress syndrome by light, scanning, and transmission electron microscopy
15. Effect of positive pressure ventilation on surface tension properties of lung extracts
16. Lung overexpansion increases pulmonary microvascular protein permeability in young lambs
17. Adverse effects of large tidal volume and low PEEP in canine acid aspiration
18. High inflation pressure pulmonary edema: Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure
19. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome
20. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome
21. Efficacy of computerized decision support for mechanical ventilation: Results of a prospective multi-center randomized trial
22. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
23. Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome
24. PEEP and low tidal volume ventilation reduce lung water in porcine pulmonary edema
25. The mechanism of lung volume change during mechanical ventilation
26. The relation of pneumothorax and other air leaks to mortality in the acute respiratory distress syndrome
27. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome