Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma

Journal of Neuro-Oncology

Volumn 49, Issue 1, 2000, Pages 63-70

  Kochi, M ^a   Kitamura, I ^a   Goto, T ^a   Nishi, T ^a   Takeshima, H ^b   Saito, Y ^a   Yamamoto, K ^a   Kimura, T ^a   Kino, T ^a   Tada, K ^a   Shiraishi, S ^a   Uemura, S ^c   Iwasaki, T ^a   Kuratsu, J I ^b   Ushio, Y ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c Amakusa Regional Medical Center   (Japan)

Author keywords

ACNU; Adjuvant therapy; Glioblastoma; Intra arterial administration; Randomized trial

Indexed keywords

NIMUSTINE;

ADJUVANT THERAPY; ADOLESCENT; ADULT; AGE; ARTICLE; BLOOD TOXICITY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; FEMALE; GLIOBLASTOMA; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 3 CLINICAL TRIAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SURVIVAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGING; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; DISEASE PROGRESSION; FEMALE; GLIOBLASTOMA; HUMANS; INFUSIONS, INTRA-ARTERIAL; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NIMUSTINE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 0033663476     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006457502972     Document Type: Article

References (24)

1. Combined radiotherapy and chemotherapy with dibromodulcitol and CCNU in the postoperative treatment of malignant gliomas
2. Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma
3. Adjuvant therapy with dibromodulcitol and BCNU increases survival of adults with malignant gliomas
4. Effects of ACNU and radiotherapy on malignant glioma
5. Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas
6. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery
7. Pharmacodynamics and the blood-brain barrier
8. 14C-BCNU in the squirrel monkey
9. Distribution of radiolabeled 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in rat brain tumor: Intrarterial versus intra-venous administration
10. Intra-arterial therapy for brain tumors
11. Sample size needed for a clinical trial
12. Theoretic limitations of intracarotid infusions in brain tumor chemotherapy
13. Intra-arterial BCNU chemotherapy for treatment of malignant gliomas of the central nervous system
14. The rationale and methodology for intra-arterial chemotherapy with BCNU as treatment for glioblastoma
15. A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma
16. Adjuvant intraarterial chemotherapy with nimustine in the management of World Health Organization grade IV gliomas of the brain
17. Treatment of malignant gliomas with surgery, intraarterial chemotherapy with ACNU and radiation therapy
18. Intra-arterial chemotherapy with ACNU and radiotherapy in inoperable malignant gliomas
19. Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: A pathological study
20. Leukoencephalopathy associated with intra-arterial ACNU in patients with gliomas
21. Central neurotoxicity following intracarotid BCNU chemotherapy for malignant gliomas
22. Intravascular streaming during carotid artery infusions
23. Cell killing action of cellcycle phase-non-specific antitumor agents is dependent on concentration-time product