The effect of compression and decompression speed on the mechanical strength of compacts

Pharmaceutical Development and Technology

Volumn 5, Issue 4, 2000, Pages 485-494

  Ruegger, Colleen E ^a   Çelick, Metin ^b,c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Pharmaceutical Technologies International Inc   (United States)

^c PTI Inc   (United States)

Author keywords

Compactability; Compaction simulator; Crushing strength; Integrated compaction research system; Porosity change; Speed of compression and decompression

Indexed keywords

IBUPROFEN; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; STARCH;

ARTICLE; COMPRESSION; DECOMPRESSION; DRUG MANUFACTURE; MECHANICS; POWDER; PRIORITY JOURNAL; STRENGTH; TABLET; VELOCITY;

POWDERS; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH;

EID: 0033662019     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100102032     Document Type: Article

References (30)

1. Effect of particle size and speed of compaction on density changes in tablets of crystalline and spray-dried lactose
2. The effect of high speed compression at sub-atmospheric pressures on the capping tendency of pharmaceutical tablets
3. The effect of punch velocity on the compaction of a variety of materials
4. The effect of the relationship between punch velocity and particle size on the compaction behavior of materials with varying deformation mechanisms
5. The effect of duration of compression on the axial recovery properties of compacts of a crystalline drug substance
6. The effect of punch velocity on the tensile strength of aspirin tablets
7. Punch velocities during the compaction process
8. The effect of compression speed on the properties of ibuprofen tablets
9. The effect of machine speed on the consolidation of four directly compressible tablet diluents
10. Considerations of compression speed in tablet manufacture
11. The effect of rate of force application on the properties of microcrystalline cellulose and dibasic calcium phosphate mixtures
12. An investigation into the capping of paracetamol at increasing speeds of compression
13. An investigation of the effect of the punch velocity on the compaction properties of ibuprofen
14. The strength of compressed tablets III. The relation of particle size, bonding, and capping in tablets of sodium chloride, aspirin, and hexamine
15. Direct compression of tablets
16. Effect of physical properties on compression characteristics
17. Physical processes of tabletting
18. Plastic flow during compression of directly compressible fillers and its affect on tablet strength
19. Time-dependent deformation of some directly compressible excipients
20. Estimation of elastic recovery, work of decompression, and young's modulus using a rotary tablet press
21. The effect of machine speed on the compaction of some directly compressible tablet diluents
22. Effect of compression speed on the relationship between normalised solid fraction and mechanical properties of compacts
23. The pharmaceutical compaction research laboratory and information center
24. The tensile strength of lactose tablets
25. Feasibility study for the development of a prospective compaction functionality test and establishment of a compaction data bank
26. The effect of some binding agents on the mechanical properties of granules and their compression characteristics
27. Densification behaviour of drugs presenting availability problems
28. A comparative investigation of compression simulators
29. Compression characteristics of binary mixtures