Control of growth hormone (GH) release by GH secretagogues

Novartis Foundation Symposium

Volumn 227, Issue , 2000, Pages 206-224

  Robinson, Iain C A F ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE RECEPTOR;

ANIMAL; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; GROWTH HORMONE; HUMANS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 0033661134     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (45)

1. Barinaga M, Bilezikjian LM, Vale WW, Rosenfeld MG, Evans RM 1985 Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. Nature 314:279-281
2. Baumbach WR, Carrick TA, Pausch MH et al 1998 A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats. Mol Pharmacol 54:864-873
3. Bennett PA, Thomas GB, Howard AD et al 1997 Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat. Endocrinology 138:4552-4557
4. Bowers CY, Momany F, Reynolds GA, Hong A 1984 On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114:1537-1545
5. Burton KA, Kabigting EB, Clifton DK, Steiner RA 1992 Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons. Endocrinology 131:958-963
6. Burton KA, Kabigting EB, Steiner RA, Clifton DK 1995 Identification of target cells for growth hormone's action in the arcuate nucleus. Am J Physiol 232:E716-E722
7. Carlsson L, Jansson JO 1990 Endogenous growth hormone (GH) secretion in male rats is synchronized to pulsatile GH infusions given at 3-hour intervals. Endocrinology 126:6-10
8. Charlton HM, Clark RG, Robinson ICAF et al 1988 Growth hormone-deficient dwarfism in the rat: a new mutation. J Endocrinol 119:51-58
9. Clark RG, Robinson ICAF 1985 Growth hormone responses to multiple injections of a fragment of human growth hormone-releasing factor in conscious male and female rats. J Endocrinol 106:281-289
10. Clark RG, Robinson ICAF 1988 Paradoxical growth promoting effects induced by patterned infusions of somatostatin in female rats. Endocrinology 122:2675-2682
11. Clark RG, Jansson JO, Isaksson O, Robinson ICAF 1985 Intravenous growth hormone: growth responses to patterned infusions. J Endocrinol 104:53-61
12. Clark RG, Chambers G, Lewin J, Robinson ICAF 1986 Automated repetitive microsampling of blood: growth hormone secretion in conscious male rats. J Endocrinol 111:27-35
13. Clark RG, Carlsson LMS, Robinson ICAF 1987 Growth hormone secretory profiles in conscious female rats. J Endocrinol 114:399-407
14. Clark RG, Carlsson LMS, Rafferty B, Robinson ICAF 1988a The rebound release of growth hormone (GH) following somatostatin infusion in rats involves hypothalamic GH-releasing factor release. J Endocrinol 119:397-404
15. Clark RG, Carlsson LMS, Robinson ICAF 1988b Growth hormone (GH) secretion in the conscious rat: negative feedback of GH on its own release. J Endocrinol 119:201-209
16. Clark RG, Carlsson LMS, Trojnar J, Robinson ICAF 1989 The effects of a growth hormone-releasing peptide and growth hormone-releasing factor in conscious and anaesthetized rats. J Neuroendocrinol 1:249-255
17. Clark RG, Mortensen DL, Carlsson LM, Carlsson B, Carmignac D, Robinson ICAF 1996 The obese growth hormone (GH)-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-I. Endocrinology 137:1904-1912
18. De Meyts P, Shymko RM 2000 Timing-dependent modulation of insulin mitogenic versus metabolic signalling. In: Mechanisms and biological significance of pulsatile hormone secretion Wiley, Chichester (Novartis Found Symp 227) p 46-60
19. Dickson SL, Leng G, Robinson ICAF 1993 Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons. Neuroscience 53:303-306
20. Edén S 1979 Age- and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology 105:555-560
21. Epelbaum J, Moyse E, Tannenbaum GS, Kordon C, Beaudet A 1989 Combined autoradiographic and immunohistochemical evidence for an association of somatostatin binding sites with growth hormone-releasing factor-containing nerve cell bodies in the rat arcuate nucleus. J Neuroendocrinol 1:109-115
22. Eriksson L, Frankenne F, Edén S, Hennen G, Von Schoultz B 1989 Growth hormone 24 h serum profiles during pregnancy - lack of pulsatility for the secretion of the placental variant. Br J Obstet Gynaecol 96:949-953
23. Fairhall KM, Mynett A, Smith RG, Robinson ICAF 1995 Consistent GH responses to repeated injection of GH-releasing hexapeptide (GHRP-6) and the non-peptide GH secretagogue, L-692 585. J Endocrinol 145:417-426
24. Flavell DM, Wells T, Wells SE, Carmignac DF, Thomas GB, Robinson ICAF 1996 Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. EMBO J 15:3871-3879
25. Gevers EF, Wit JM, Robinson ICAF 1996 Growth, growth hormone (GH)-binding protein, and GH receptors are differentially regulated by peak and trough components of the GH secretory pattern in the rat. Endocrinology 137:1013-1018
26. Giustina A, Veldhuis JD 1998 Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human. Endocr Rev 19:717-797
27. Hammer RE, Brinster RL, Rosenfeld MG, Evans RM, Mayo KE 1985 Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Nature 315:413-416
28. Howard AD, Feighner SD, Cully DF et al 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
29. Jansson JO, Albertsson-Wikland K, Edén S, Thorngren KG, Isaksson OGP 1982 Effect of frequency of growth hormone administration on longitudinal bone growth and body weight in hypophysectomised rats. Acta Physiol Scand 114:261-265
30. Jeffery S, Carter ND, Clark RG, Robinson ICAF 1990 The episodic secretory pattern of growth hormone regulates liver carbonic anhydrase III. Studies in normal and mutant growth hormone-deficient dwarf rats. Biochem J 266:69-74
31. Lin S-C Lin C, Gukovsky I, Lusis A, Sawchenko P, Rosenfeld M 1993 Molecular basis of the little mouse phenotype and implications for cell-type specific growth. Nature 364:208-213
32. McDowell RS, Elias KA, Stanley MS et al 1995 Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation. Proc Natl Acad Sci USA 92:11165-11169
33. Pellegrini E, Carmignac DF, Bluet-Pajot MT et al 1997 Intrahypothalamic growth hormone feedback: from dwarfism to acromegaly in the rat. Endocrinology 138:4543-4551
34. Robinson ICAF, Hindmarsh PC 1999 The importance of the GH secretory pattern for statural growth. In: Kostyo JL (ed) American handbook of physiology, vol 5: Hormonal control of growth. Oxford University Press, New York, in press
35. Smith RG, Van der Ploeg LH, Howard AD et al 1997 Peptidomimetic regulation of growth hormone secretion. Endocr Rev 18:621-645
36. Tannenbaum GS, Ling N 1984 The interrelationship of growth hormone (GH)-releasing factor and somatostatin in the generation of the ultradian rhythm of GH secretion. Endocrinology 115:1952-1957
37. Tannenbaum GS, Martin JB 1976 Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 98:562-570
38. Thomas GB, Cummins JT, Francis H, Sudbury AW, McCloud PI, Clarke IJ 1991 Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes. Endocrinology 128:1151-1158
39. Thorner MO, Perryman RL, Cronin MJ et al 1982 Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumour secreting an growth hormone-releasing factor. J Clin Investig 70:965-977
40. Wagner C, Caplan SR, Tannenbaum GS 1998 Genesis of the ultradian rhythm of GH secretion: a new model unifying experimental observations in rats. Am J Physiol 275:E1046-E1054
41. Waxman DJ 2000 Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression. In: Mechanisms and biological significance of pulsatile hormone secretion. Wiley, Chichester (Novartis Found Symp 227) p 61-81
42. Wehrenberg WB, Ling N, Böhlen P, Esch F, Brazeau P, Guillemin R 1982 Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion. Biochem Biophys Res Comm 109:562-567
43. Wells T, Mode A, Floby E, Robinson ICAF 1994 The sensitivity of hepatic CYP2C gene expression to baseline growth hormone (GH) bioactivity in dwarf rats: effects of GH-binding protein in vivo. Endocrinology 134:2135-2141
44. Wells T, Flavell DM, Wells SE, Carmignac DF, Robinson ICAF 1997 Effects of growth hormone secretagogues in the transgenic growth-retarded (Tgr) rat. Endocrinology 138:580-587
45. Willoughby J, Brogan M, Kapoor R 1989 Hypothalamic interconnections of somatostatin and growth hormone releasing factor on growth hormone secretion. Neuroendocrinology 50:584-591