Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats. 5) Effects of repeated doses of flutamide for 2 and 4 weeks

Journal of Toxicological Sciences

Volumn 25, Issue SPEC. ISS, 2000, Pages 63-70

  Okahara, A ^a   Nomura, A ^a   Tanioka, H ^a   Sakamoto, H ^a   Yamashita, K ^a   Ikuse, T ^a  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Flutamide; Male reproductive system; Rats; Testes; Toxicity

Indexed keywords

FLUTAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AZOOSPERMIA; CELL PROLIFERATION; CONTROLLED STUDY; EPIDIDYMIS; LEYDIG CELL; MALE; MALE GENITAL SYSTEM; NONHUMAN; PROSTATE; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SPERMATOZOON MOTILITY; TESTIS INJURY;

ANIMALIA;

EID: 0033659618     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.25.specialissue_63     Document Type: Article

References (8)

1. New tables for multiple comparison with a control
2. A fertility study in male rats treated orally with flutamide
3. Action of a nonsteroidal antiandrogen, flutamide, on the receptor binding and nuclear retention of 5 α -dihydrotestosterone in rat ventral prostate
4. A biological profile of a nonsteroidal antiandrogen, SCH 13521(4'-nitro-3'-trifluoromethylisobutyranilide)
5. On the mechanism of the anti-androgenic action of flutamide(α-α- α-Trifluoro-2-methyl-4'-nitro-mpropionotoluidide) in the rat
6. Studies on the optimal treatment period and parameters for detection of male fertility disorder in rats -Introductory summary-
7. Endocrinological and histological changes induced by flutamide treatment on the hypothalamo-hypophyseal testicular axis of the adult male rat and their incidences on fertility
8. A 52-week oral toxicity study of flutamide in male rats followed by recovery test