Single ion actions: The induction of micronuclei in V79 cells exposed to individual protons

Advances in Space Research

Volumn 25, Issue 10, 2000, Pages 2095-2101

  Prise, K M ^a   Folkard, M ^a   Malcolmson, A M ^a   Pullar, C H L ^a   Schettino, G ^a   Bowey, A G ^a   Michael, B D ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHALASIN B; PROTON;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; CHROMOSOME; CRICETULUS; DRUG EFFECT; HAMSTER; INSTRUMENTATION; LINEAR ENERGY TRANSFER; MAGNETIC AND ELECTROMAGNETIC EQUIPMENT; MICRONUCLEUS; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOBIOLOGY;

ANIMALS; CELL LINE; CELLS, CULTURED; CHROMOSOMES; CRICETINAE; CRICETULUS; CYTOCHALASIN B; DOSE-RESPONSE RELATIONSHIP, RADIATION; LINEAR ENERGY TRANSFER; MICRONUCLEI, CHROMOSOME-DEFECTIVE; PARTICLE ACCELERATORS; PROTONS; RADIATION DOSAGE; RADIOBIOLOGY;

EID: 0033654507     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-1177(99)01060-1     Document Type: Article

References (21)

1. Almassay, Z., A. B. Krepinsky, A. Bianco, and C. J. Koteles, The Present State and Perspectives of Micronucleus Assay in Radiation Protection. Int. J Rad. App.Inst., 38, 241-249 (1987).
2. Bertsche, U., Micronucleus Induction in Mammalian Cell Cultures Treated with Ionizing Radiations. Rad. Environ. Biophys., 24, 27-44 (1985).
3. Braby, L. A., Microbeam Studies of the Sensitivity of Structures within Living Cells. Scanning Microsc., 6, 167-174 (1992).
4. Braby, L. A., A. L. Brooks, and N. F. Metting, Cellular Effects of Individual High-Linear Energy Transfer Particles and Implications for Tissue Response at Low Doses. Radiat. Res., 148, S108-114 (1997).
5. Cornforth, M. N., and E. H. Goodwin, Transmission of Radiation-Induced Acentric Chromosomal Fragments to Micronuclei in Normal Human Fibroblasts. Radiat. Res., 126, 210-217 (1991).
6. Courdi, A., D. Mari, J. Herault, and P. Chauvel, Micronucleus Induction and Reproductive Death in a Human Cell Line Exposed to Low-Energy Argon Beam. Rad. Environ. Biophys., 34, 85-89 (1995).
7. Edwards, A. A., D. C. Lloyd, and R. J. Purrott,. Radiation Induced Chromosome Aberrations and the Poisson Distribution. Rad. Environ. Biophys., 16, 89-100 (1979)
8. Fenech, M., and A. A. Morley, Kinetochore Detection in Micronuclei: an Alternative Method for Measuring Chromosome Loss. Mutagenesis. 4, 98-104 (1989).
9. Folkard, M., K. M. Prise, B. Vojnovic, H. C. Newman, M. J. Roper, and B. D. Michael, Inactivation of V79 Cells by Low-Energy Protons, Deuterons and Helium-3 Ions. Int. J. Radiat. Biol. 69, 729-738 (1996).
10. Folkard, M., B. Vojnovic, K. M. Prise, A. G. Bowey, R. J. Locke, G. Schettino, and B. D. Michael, A Charged-Particle Microbeam I. Development of an Experimental System for Targeting Cells Individually with Counted Particles. Int. J. Radiat. Biol., 72, 375-385. (1997a).
11. Folkard, M., B. Vojnovic, K. J. Hollis, A. G. Bowey, S. J. Watts, G. Schettino, K. M. Prise, and B. D. Michael, A Charged Particle Microbeam: II A Single-Particle Micro-Collimation and Detection System. Int. J. Radiat. Biol., 72, 387-395 (1997b).
12. Geard, C.R., D.J. Brenner, G. Randers-Pehrson, and S.A. Marino, Single-particle Irradiation of Mammalian Cells at the Radiological Research Accelerator Facility: Induction of Chromosomal Changes. Nucl. Instr. Meth., B54, 411-416 (1991).
13. Grote, S. J., G. P. Joshi, S. H. Revell, and C. A. Shaw, Observations of Radiation-Induced Chromosome Fragment Loss in Live Mammalian Cells in Culture, and its Effect on Colony-Forming Ability. Int. J. Radiat. Biol., 39, 395-608 (1981).
14. Hurwitz, S. J., and L. Hlatky, Assessment of Radiation Response on a Cell by Cell Basis using In Situ Densitometric Imaging of Micronuclei. Radiat. Res., 134, 112-116 (1993).
15. Kahn, M. A., F. T. Cross, R. Jostes, E. Hue, J. E. Morris, and A. L. Brooks, Micronuclei Induced by Radon and its Progeny in Deep-Lung Fibroblasts of Rats In Vivo and In Vitro. Radiat. Res.,139, 53-59 (1994).
16. Manti, L., M. Jamali, K. M. Prise, B. D. Michael, and K.-R. Trott, Genomic Instability in Chinese Hamster Cells after Exposure to X Rays or Alpha Particles of Different Mean Linear Energy Transfer. Radiat. Res., 147, 22-28 (1997).
17. Nelson, J. M., A.L. Brooks, N. F. Metting, M. A. Kahn, R. L. Buschbom, A. Duncan, R. Miick, and L. A. Braby, Clastogeneic Effects of Defined Numbers of 3.2MeV Alpha-Particles on Individual CHO-K1 Cells. Radiat. Res., 145, 568-574 (1996).
18. Revell, S. H., Relationships between Chromosome Damage and Cell Death. In Radiation-induced Chromosome Damage in Man, (A. R. Liss, New York) pp. 215-233 (1983).
19. Savage, J. R. K., Acentric Chromosomal Fragments and Micronuclei: The Time Displacement Factor. Mutat. Res., 225, 171-173 (1989).
20. Savage, J. R. K., A Comment on the Quantitative Relationships between Micronuclei and Chromosomal Aberrations. Mutat. Res., 207, 33-36 (1988).
21. Streffer C., Is the Micronucleus Assay Predictive for Cellular Radiosensitivity? Brit. J. Radiol. Suppl 24, 70-73 (1992).