Expression of estrogen receptor exon 5 and 7 deletion variant in human breast cancers

Breast Cancer

Volumn 7, Issue 1, 2000, Pages 27-31

  Omoto, Yoko ^a   Iwase, Hirotaka ^a   Iwata, Hiroji ^b   Hara, Yasuo ^a   Toyama, Tatsuya ^a   Ando, Yoshiaki ^a   Kobayashi, Shunzo ^c  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c Higashi Municipal Hospital of Nagoya   (Japan)

Author keywords

Alternative splicing; Deletion variant; Estrogen receptor; Human breast cancer

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; MESSENGER RNA; RNA; TUMOR PROTEIN;

ARTICLE; BIOSYNTHESIS; BREAST; BREAST TUMOR; COMPARATIVE STUDY; EXON; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PAGET NIPPLE DISEASE; POLYMERASE CHAIN REACTION;

BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; ESTROGEN RECEPTOR ALPHA; EXONS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; RNA, MESSENGER; RNA, NEOPLASM; SEQUENCE DELETION;

EID: 0033654125     PISSN: 13406868     EISSN: 18804233     Source Type: Journal    
DOI: 10.1007/BF02967184     Document Type: Article

References (22)

1. Topper J, Freedman C: Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev 60:1049-1060, 1980.
2. Vorherr H: Morphology, physiology and lactation. In: The Breast, pp119-165, 1974.
3. McGuire WL, Carbone PP, Vollmer EP eds: Estrogen Receptors in Human Breast Cancer, Raven Press, New York, 1975.
4. Dickson RB, Lippman ME: Cellular and molecular biology. In: Lippman ME, Dickson RB eds, Breast Cancer, pp119-165, 1988
5. Read LD, Snider CE, Miller JS, et al: Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines. Mol Endocrinol 2:263-271, 1988. (Pubitemid 18095176)
6. Jakowlew SB, Breathnach R, Teltsa JM, et al: Sequence of pS2 mRNA induced by estrogen in the human breast cancer cell lines. Nucleic Acids Res 12: 2861-2878, 1984.
7. Dubik D, Shiu RPC: Transcriptional regulation of cmyc oncogene expression by estrogen in hormoneresponsive human breast cancer cells. J Biol Chem 263:12705-12708, 1988. (Pubitemid 19000455)
8. Bates SE, Davidson NE, Valverius EM, et al: Expression of transforming growth factor and its messenger ribonucleic acid in human breast cancer; Its regulation by estrogen and its possible functional significance. Mol Endocrinol 2:543-555, 1988.
9. Green S, Walter P, Kumar V, et al: Human oestrogen receptor cDNA; Sequence, expression and homology to v-erb-A. Nature 320:134-139, 1986. (Pubitemid 16105150)
10. Ponglikitmongkol M, Green S, Chambon P: Genomic organization of the human oestrogen-receptor gene. EMBO J 7:3385-3388, 1988.
11. Roodi N, Bailey LR, Kao W-Y, et al: Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer. J Natl Cancer Inst 87:446-451, 1995.
12. Leygue ER, Watson PH, Murphy LC: Estrogen-receptor variants in normal human mammary tissue. J Natl Cancer Inst 88: 284-290, 1996. (Pubitemid 26073373)
13. Pfeffer U, Fecarotta E, Arena G, et al: Alternative splicing of the estrogen-receptor primary transcript normally occurs in estrogen-receptor- positive tissues and cell lines. J Steroid Biochem Mol Biol 56:99-105, 1996. (Pubitemid 26106513)
14. Pfeffer U, Fecarotta E, Vidali G: Co-expression of multiple estrogen-receptor-variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res 55:2158-2165, 1995.
15. Leygue ER, Huang A, Murphy LC, et al: Prevalence of estrogen receptor variant messenger RNAs in human breast cancer. Cancer Res 56:4324-4327, 1996. (Pubitemid 26330430)
16. Wang Y, Miksicek RJ: Identification of a dominant negative form of the human estrogen receptor. Mol Endocrinol 5:1707-1715, 1991.
17. Fuqua SAW, Fitzgerald SD, Allred DC, et al: Inhibition of estrogen receptor action by a naturally occuring variant in human breast tumors. Cancer Res 52:483-486, 1992.
18. Fuqua SAW, Fitzgerald SD, Chamness GC, et al: Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res 51:105-109, 1991.
19. Castles CG, Fuqua SAW, Klotz DM, et al: Expression of a constitutively active estrogen-receptor variant in the estrogen-receptor-negative BT-20 human breastcancer cell line. Cancer Res 53:5934-5939, 1993. (Pubitemid 24006163)
20. Ohlsson H, Lykkesfeldt AE, Madsen MW, et al: The estrogen receptor variant lacking exon 5 has dominant negative activity in the human breast epithelial cell line HMT-3522S1. Cancer Res 58:4264-4268, 1998. (Pubitemid 28450022)
21. Madsen MW, Reiter BE, Larsen SS, et al: Estrogen receptor messenger RNA splice variants are not involved in antiestrogen resistance in sublines of MCF-7 human breast cancer cells. Cancer Res 57: 585-589, 1997. (Pubitemid 27085636)
22. Gallacchi P, Schoumacher F, Eppenberger-Castori S, et al: Increased expression of estrogen-receptor exon-5-delefion variant in relapse tissues of human breast cancer. Int J Cancer 79:44-48, 1998. (Pubitemid 28157725)