Dextromethorphan, an NMDA-receptor antagonist, enhances the analgesic properties of morphine

Inflammopharmacology

Volumn 8, Issue 2, 2000, Pages 161-173

  Caruso, F S ^a   Goldblum, R ^a  

^a Algos Pharmaceutical Corporation   (United States)

Author keywords

Analgesic; Dextromethorphan; MorphiDex ; Morphine; NMDA receptor antagonist

Indexed keywords

DEXTROMETHORPHAN; DEXTROMETHORPHAN PLUS MORPHINE; MORPHINE SULFATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PLACEBO; PROTEIN KINASE C;

ADULT; AGED; ANALGESIA; ARTICLE; CANCER PAIN; CHRONIC PAIN; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RELEASE; DRUG SAFETY; FEMALE; HEADACHE; HUMAN; HYPERALGESIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; PATIENT COMPLIANCE; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PAIN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; SYNAPTIC TRANSMISSION; VOMITING;

EID: 0033652138     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1163/15685600038189     Document Type: Article

References (9)

1. Update on the neurophysiology of pain transmission and modulation: Focus on the NMDA receptor
2. MorphiDex® pharmacokinetic studies and single-dose analgesic efficacy studies in patients with postoperative pain
3. Lack of pharmacokinetic interaction between morphine and dextromethorphan in healthy volunteers
4. Morphine with dextromethorphan: Conversion from other opioid analgesics
5. Long-term safety of MorphiDex®
6. MorphiDex® (MS:DM) double-blind, multiple-dose studies in chronic pain patients
7. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions
8. NMDA-receptor antagonists and opioid receptor interactions as related to analgesia and tolerance
9. Therapeutic potential of excitatory amino acid antagonists: Channel blockers and 2,3 benzodiazepines