A prospective randomized multicenter study of chlormadinone acetate versus flutamide in total androgen blockade for prostate cancer

Japanese Journal of Clinical Oncology

Volumn 30, Issue 9, 2000, Pages 389-396

  Ozono, Seiichiro ^a   Okajima, Eigoro ^a   Yamaguchi, Akira ^a   Yoshikawa, Motoyoshi ^a   Iwai, Akio ^a   Moriya, Akira ^a   Yoshida, Katsunori ^a   Samma, Shoji ^a   Maruyama, Yoshio ^a   Hirao, Yoshihiko ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Chlormadinone acetate; Flutamide; Liver function; Prostate cancer; Total androgen blockade

Indexed keywords

ALANINE AMINOTRANSFERASE; ANDROGEN; ANTIANDROGEN; ASPARTATE AMINOTRANSFERASE; CHLORMADINONE ACETATE; FLUTAMIDE; GONADORELIN DERIVATIVE; LUTEINIZING HORMONE; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE;

AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENTIATION; DRUG TOLERABILITY; HOT FLUSH; HUMAN; LIVER DYSFUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PROSPECTIVE STUDY; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL; SWEAT GLAND DISEASE; TESTOSTERONE BLOOD LEVEL;

EID: 0033652136     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: 10.1093/jjco/hyd106     Document Type: Article

References (19)

1. Total androgen blockade. Concept, theory, method and clinical application
2. The effects anti-androgenic anents on metabolism and biosynthesis of testosterone (I): Testosterone metabolic regulation in the liver and the biosynthesis in the testes on rats treated with chlormadinone acetate
3. Clinical study on chlormadinone acetate alone followed by combination with LH-RH analog for prostatic cancer: Effects on lipid metabolism
4. Pretreatment with chlormadinone acetate in prostate cancer patients treated with a luteinizing hormone-releasing hormone analogue
5. Maximal androgen blockade: Final analysis of EOERC phase III trial 30853
6. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma
7. Bilateral orchiectomy with or without flutamide for metastatic prostate cancer
8. Maximum androgen blockade in advanced prostate cancer: An overview of 22 randomised trials with 3283 deaths in 5710 patients
9. Maximum androgen blockade in advanced prostate cancer: A meta-analysis of published randomized controlled trials using nonsteroidal antiandrogens
10. Dynamics of prostate-specific antigen as prognostic factors in endocrine treatment for prostate cancer
11. Early results of LH-RH agonist treatment with or without chlormadinone acetate for hormone therapy of naive localized or locally advanced prostate cancer: A prospective and randomized study
12. A prospective, randomized study to compare goserelin acetate (Zoladex®) versus cyproterone acetate(Cyprostat®) versus a combination of the two in the treatment of metastatic prostatic carcinoma
13. A randomized phase II trial of flutamide vs chlormadinone acetate in previously untreated advanced prostatic cancer
14. Post-orchiectomy hot flushes
15. Preliminary trial for clinical phase III study of casodex (Bicalutamide ICI176,334) combination therapy with LH-RH agonist for prostate cancer
16. Clinical benefits of bicalutamide compared with flutamide in combined androgen blockade for patients with advanced prostatic carcinoma: Final report of a double-blind, randomized, multicenter trial
17. A prospective, randomised study to compare goserelin acetate (Zoladex 8) versus a combination of the two in the treatment of metastatic prostatic carcinoma
18. Prevention of hot flushes with CPA in the hormonal treatment of prostatic cancer: Results of a placebo-controlled double-blind trial
19. Hot flushes: Mechanism and prevention