Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats. 18) Comparative 4 and 2 weeks oral repeated dosing studies on male reproductive organs in rats treated with 5-fluorouracil

Journal of Toxicological Sciences

Volumn 25, Issue SPEC. ISS, 2000, Pages 179-186

  Inomata, A ^a   Matsumoto, H ^a   Horii, I ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

2 Week study; 4 week study; 5 Fluorouracil; Male reproductive organs; Sprague Dawley Rats

Indexed keywords

FLUOROURACIL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CELL VACUOLE; CONTROLLED STUDY; EPIDIDYMIS; FECES; GIANT CELL; HISTOPATHOLOGY; MALE; MALE GENITAL SYSTEM; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE EPITHELIUM; SERTOLI CELL; TESTIS WEIGHT; TOXICITY TESTING; WEIGHT REDUCTION;

ANIMALIA;

EID: 0033647466     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.25.specialissue_179     Document Type: Article

References (13)

1. Differential susceptibility of immature rat testes to doxorubicin at critical stages of maturation. Biochemical and functional assessment
2. Metabolism and testicular toxicity of 1,3-dinitrobenzene in rats of different ages
3. Effects of 5-fluorouracil on mRNA
4. Protein secretions of Sertoli cells
5. Follicle-stimulating hormone regulation of androgen-binding protein messenger RNA on Sertoli cell cultures
6. Toxicity study of doxifluridine (4) Comparative 5 weeks oral toxicity study with FT-207 and 5-FU in rats
7. Safety evaluation of oral 5-fluorouracil (acute, subacute, chronic toxicity and teratological studies)
8. Synthetic activities during spermatogenesis in the mouse
9. A collaborative study in Japan on optimal treatment period and parameters for detection of male fertility disorders induced by drugs in rats
10. Detection of effects on male reproduction-A literature survey
11. Combination cytotoxic differentiation therapy of mouse erythroleukemia cells with 5-fluorouracil and hexamethylene bisacetamide