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Volumn 48, Issue 11, 2000, Pages 1644-1651
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Highly potent and orally active non-peptide arginine vasopressin antagonists for both V(1A) and V2 receptors: Synthesis and pharmacological properties of 4'-[(4,4,-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)car bonyl]-2-phenylbenzanilide derivatives
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Author keywords
Arginine vasopressin antagonist; Congestive heart failure; Difluorination; YM 35471
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Indexed keywords
4' [(4,4 DIFLUORO 5 METHYLIDENE 2,3,4,5 TETRAHYDRO 1H 1 BENZOAZEPIN 1 YL)CAROBNYL] 2 PHENYLBENZANILIDE DERIVATIVE;
4' [[5 [(4 DIMETHYLAMINOPIPERIDINO)CARBONYLMETHYLENE] 4,4 DIFLUORO 2,3,4,5 TETRAHYDRO 1H 1 BENZAZEPIN 1 YL]CARBONYL] 2 PHENYLBENZANILIDE;
ANILIDE;
ARGIPRESSIN RECEPTOR;
UNCLASSIFIED DRUG;
VASOPRESSIN RECEPTOR ANTAGONIST;
VASOPRESSIN V1 RECEPTOR;
VASOPRESSIN V2 RECEPTOR;
ARTICLE;
BINDING AFFINITY;
CONGESTIVE HEART FAILURE;
DEFLUORINATION;
DRUG ACTIVITY;
DRUG POTENCY;
DRUG RECEPTOR BINDING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;
PHARMACOLOGICAL BLOCKING;
RAT;
RECEPTOR BLOCKING;
STRUCTURE ACTIVITY RELATION;
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EID: 0033647332
PISSN: 00092363
EISSN: None
Source Type: Journal
DOI: 10.1248/cpb.48.1644 Document Type: Article |
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Times cited : (35)
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References (21)
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