Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats. 11) Testicular toxicity of 2- or 4-week repeated or single-dose administration of a novel platinum complex

Journal of Toxicological Sciences

Volumn 25, Issue SPEC. ISS, 2000, Pages 117-127

  Misawa, Y ^a   Watanabe, K ^a   Sakurai, T ^a   Fujii, E ^a   Tsukamoto, K ^a   Kato, A ^a   Sugimoto, T ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Platinum complex; Rat; Testis; Toxicity

Indexed keywords

PLATINUM COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GIANT CELL; MALE; MALE GENITAL SYSTEM; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; TESTIS ATROPHY; TESTIS INJURY; TESTIS WEIGHT;

ANIMALIA;

EID: 0033647127     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.25.specialissue_117     Document Type: Article

References (10)

1. Antitumor activity of a new platinum complex, 2-aminomethyl -pyrrolidine (1,1-cyclobutanedicarboxylato) platinum (II)
2. Acute and chronic effects of cisplatinum upon testicular function in the rat
3. Short term effects of cis-platinum on male reproduction, fertility and pregnancy outcome
4. Effects of carboplatin on the testis; A histological study
5. Effect of a new platinum complex on male fertility in rats
6. Characterization of cis-platinum-induced Sertoli cell dysfunction
7. Effects of subchronic treatment with cis-platinum on testicular function, fertility, pregnancy outcome, and progeny
8. Single-dose intravenous toxicity study of DWA2114R in mice, rats and dogs