Selection of CD34-positive blood cells for allogeneic transplantation: Approaches to optimize CD34-cell recovery, purity, viability, and T-cell depletion

Onkologie

Volumn 23, Issue 5, 2000, Pages 449-456

  Fritsch, G ^a   Scharner, D ^a   Froschl G ^a   Buchinger, P ^a   Peters, C ^b   Matthes, S ^b   Witt, V ^b   Gadner, H ^a,b  

^a Forsch Inst fur Krebskranke Kinder   (Austria)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

CD34 positive selection Immunomagnetic selection; Transplantations (HLA mismatched; HLA haploidentical)

Indexed keywords

CD34 ANTIGEN; DEOXYRIBONUCLEASE; MONOCLONAL ANTIBODY;

ARTICLE; BLOOD CELL; CELL SEPARATION; CELL VIABILITY; HEMATOPOIETIC CELL; HLA MATCHING; STEM CELL; T LYMPHOCYTE; TRANSPLANTATION;

EID: 0033646753     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Monoclonal antibody 12-8 recognizes a 115-kd molecule present on both unipotent and multipotent hematopoietic colony-forming cells and their precursors
2. Identification and comparison of CD34-positive cells and their subpopulations from normal peripheral blood and bone marrow using multicolor flow cytometry
3. The hematopoietic stem cell antigen, CD34, is not expressed on the malignant cells in multiple myeloma
4. Multiple myeloma clones are derived from a cell late in B lymphoid development
5. Engraftment after infusion of CD34+ marrow cells in patients with breast cancer or neuroblastoma
6. Human monomyeloid cell membrane antigens
7. An improved panning technique for the selection of CD34+ human bone marrow hematopoietic cells with high recovery of early progenitors
8. Lymphocyte dose modification of the bone marrow allograft using elutriation
9. Removal of neuroblastoma cells from bone marrow with monoclonal antibodies conjugated to magnetic microspheres
10. Transplantation of stem cells enriched by immunoadsorption
11. Flow cytometric monitoring of hematopoietic reconstitution in myeloablated patients following allogeneic transplantation
12. Isolation and transplantation of autologous peripheral CD34+ progenitor cells highly purified by magnetic-activated cell sorting
13. Isolation of highly purified autologous and allogeneic peripheral CD34+ cells using the CliniMACS device
14. Quantitative CD34 analysis: Comparison of methods
15. Isolation of CD34+ cells from blood stem cell components using the Baxter Isolex system
16. CD34+ cell engraftment, ex vivo expansion, and malignant cell depletion following immunomagnetic selection
17. Rapid engraftment after allogeneic transplantation using CD34-enriched marrow cells
18. A comparison of two different systems for CD34+ selection of autologous or allogeneic PBSC collections
19. A randomized, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of hematological malignancies
20. In vovo/ex vivo T cell depletion for GVHD prophylaxis influences onset and course of active cytomegalovirus infection and disease after BMT
21. Positive/negative purging of PBSC grafts with the Isolex system: A prospective study in patients with B-CLL
22. Clinical use of allogeneic hematopoietic stem cells from sources other than bone marrow
23. CD34 augmentation improves allogeneic T cell-depleted bone marrow engraftment
24. Selective CD4+ T-cell depletion does not prevent graft-versus-host disease
25. Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease
26. Successful engraftment of T-cell-depleted haploidentical 'three-loci' incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum