Exposure of rats to a high but not low dose of ethanol during early postnatal life increases the rate of loss of optic nerve axons and decreases the rate of myelination

Journal of Anatomy

Volumn 197, Issue 3, 2000, Pages 477-485

  Harris, Simon J ^a   Wilce, Peter ^a   Bedi, Kuldip S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Fetal alcohol syndrome; Myelination

Indexed keywords

ALCOHOL; GLUTARALDEHYDE; KETAMINE; PHOSPHATE; XYLAZINE;

ALCOHOL BLOOD LEVEL; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; ELECTRON MICROSCOPY; FEMALE; FETAL ALCOHOL SYNDROME; HISTOPATHOLOGY; MOUSE; MYELINATION; NERVE FIBER GROWTH; NEWBORN; NONHUMAN; OPTIC NERVE; OPTIC NERVE DISEASE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ANALYSIS OF VARIANCE; ANIMALS; AXONS; CELL COUNT; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; FETAL ALCOHOL SYNDROME; FETAL BLOOD; GESTATIONAL AGE; MYELIN SHEATH; OPTIC NERVE; PREGNANCY; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 0033646243     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0021878299006846     Document Type: Article

References (46)

1. Optic nerve hypoplasia in an acute exposure model of the fetal alcohol syndrome
2. The effects of undernutrition during early life on the rat optic nerve fibre number and size frequency distribution
3. Morphometric analysis of the postnatal mouse optic nerve following prenatal exposure to alcohol
4. A golgi study of mouse hippocampal CA1 pyramidal neurons following perinatal ethanol exposure
5. Impaired brain growth in neonatal rats exposed to ethanol
6. Rat optic nerve: Electrophysiology, pharmacology and anatomical studies during development
7. Stereology of arbitrary particles
8. Pertubation of target directed neurite outgrowth in embryonic CNS co-cultures growth in the presence of ethanol
9. A quantitative morphological study of interstrain variation in the developing rat optic nerve
10. Recognition of the fetal alcohol syndrome in early infancy
11. Characterization of an automated apparatus for precise control of inhalation chamber ethanol vapor and blood ethanol concentrations
12. Ocular changes in the mouse embryo following acute maternal ethanol intoxication
13. Synapse-to-neuron ratio in the lateral geniculate nucleus of rats exposed chronically to ethanol
14. Promoting and directing axon outgrowth
15. Loss of axons from the optic nerve of the rat during early postnatal development
16. The determination of ethyl alcohol in blood and tissues
17. Prenatal binge-like alcohol exposure in the rat results in region-specific deficits in brain growth
18. Intracellular recording and injection study of corticospinal neurons in the rat somatosensory cortex: Effect of prenatal exposure to ethanol
19. Neuronal development and the formation of synaptic connections
20. Loss of myelinated axons is specific to the central nervous system in a mouse model of the fetal alcohol syndrome
21. Optic nerve hypoplasia in individuals affected by the fetal alcohol syndrome: A mouse model
22. Acute exposure to alcohol during early postnatal life causes a deficit in the total number of cerebellar Purkinje cells in the rat
23. Effects of limited postnatal ethanol exposure on the development of myelin and nerve fibers in rat optic nerve
24. Effects of postnatal ethanol exposure on glial cell development in rat optic nerve
25. Short-and long-term effects of combined pre- and postnatal ethanol exposure (three-trimester equivalency) on the development of myelin and axons in rat optic nerve
26. Effects of combined pre-and postnatal ethanol exposure (three-trimester equivalency) on glial cell development in rat optic nerve
27. Developmental changes in the optic nerve related to ethanol consumption in pregnant rats: Analysis of the ethanol-exposed optic nerve
28. Optic nerve hypoplasia in fetal alcohol syndrome: An update
29. Fetal ethanol exposure: A morphometric analysis of myelination in the optic nerve
30. Quantitative and morphological studies on developing optic axons in normal and enucleated albino rats
31. The development of the optic nerve in rodents
32. A quantitative morphological study of the optic nerve of pre-weaning rats
33. Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve
34. Fetal alcohol syndrome and mental retardation: Spine distribution of pyramidal cells in prenatal alcohol exposed rat cerebral cortex: A golgi study
35. Ocular abnormalities in the fetal alcohol syndrome
36. Ocular involvement in the fetal alcohol syndrome
37. Optic nerve hypoplasia: Comparative effects in children and rats exposed to alcohol during pregnancy
38. Fetal alcohol syndrome an ophthalmological and socioeducational prospective study
39. Paediatric and ophthalmologic observations in offspring of alcohol abusing mothers
40. Prenatal ethanol exposure alters the organization of hippocampal mossy fibers
41. Prenatal ethanol exposure alters the post-lesion reorganization (sprouting) of acetylcholinesterase staining in the dentate gyrus of adult rats
42. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
43. Use of pup in a cup model to study brain development
44. Myelination of the rat optic nerve during postnatal undernourishment and recovery: A morphometric analysis
45. Neuroradiological features of patients with optic nerve hypoplasia