Consequences of aquaporin 2 tetramerization for genetics and routing

Nephrology Dialysis Transplantation

Volumn 15, Issue SUPPL. 6, 2000, Pages 26-28

  Kamsteeg, Erik Jan ^a   Mulders, Sabine M ^a   Bichet, Daniel G ^b   Deen, Peter M T ^a   Van Os, Carel ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 2; ARGIPRESSIN; PROTEIN SUBUNIT; VASOPRESSIN V2 RECEPTOR;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CASE REPORT; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD STAINING; IMMUNOHISTOCHEMISTRY; KIDNEY CONCENTRATING CAPACITY; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; NEPHROGENIC DIABETES INSIPIDUS; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; STOICHIOMETRY; WATER ABSORPTION; WATER TRANSPORT; X CHROMOSOME LINKAGE;

EID: 0033645738     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/15.suppl_6.26     Document Type: Article

References (3)

1. An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex
2. An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
3. Shuttling of aquaporin-2 tetramers to the plasma membrane requires phosphorylation of three out of four aquaporin-2 monomers