Studies on mevinolin production by some fungi

Microbios

Volumn 102, Issue 401, 2000, Pages 53-61

  Shindia, A A ^a  

^a Zagazig University   (Egypt)

Author keywords

Aspergillus terreus; Hypocholesterolaemic agent; Mevinolin; Screening of fungi

Indexed keywords

MEVINOLIN;

ARTICLE; ASPERGILLUS; FUNGUS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; PH; TEMPERATURE; TIME;

ASPERGILLUS; FUNGI; HYDROGEN-ION CONCENTRATION; LOVASTATIN; SOIL MICROBIOLOGY; TEMPERATURE; TIME FACTORS;

EID: 0033644892     PISSN: 00262633     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. ALBERTS A. W., Chen J., Kuron G., Hunt V., Huff C., Hoffman C., Rothrock J., Lopez M., Joshua H., Harris E., Patchett A., Monaghan R., Currie S., Stapley E., Albers S. G., Schonberg G., Hensens O., Hirtschfield J., Hoogsten K., Liesch J. and Springer J. 1980. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol lowering agent. Proc. natn. Acad. Sci. U.S.A. 77 3975-81.
2. BU'LOCK J. D. 1974. Secondary metabolism in fungi and its relationship to growth and development. In The Filamentous Fungi. 1. Industrial Mycology. pp 33-56. Edited by J. E. Smith and D. R. Berry. Edward Arnold, London.
3. BURROW A., Jefferys E. G., Kessell R. H. J., Lloyd E. C., Lloyd P. B. and Nixon I. S. 1961. The metabolism of Gibbrella fujikuroi in stored culture. Can. J. Microbiol. 7 227.
4. DEMAIN A. L. 1968. Regulatory mechanisms and the industrial production of microbial metabolites. Lloydia 31 395-418.
5. DEMAIN A. L. 1972. Cellular and environmental factors affecting the synthesis of metabolites. J. appl. Chem. Biotech. 22 345-62.
6. ENDO A. 1979. Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J. Antibiot. 32 852-4.
7. ENDO A. 1988. Chemistry, biochemistry and pharmacology of HMG CoA reductase inhibitors. Klin. Wochenschr. 66 421-7.
8. ENDO A., Hasumi K. and Negishi S. 1985. Monacolins JANDL, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J. Antibiot. 38 420-2.
9. ENDO A., Kuroda M. and Tsujita Y. 1976. ML-236A, ML 236B and ML 236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. 29 1346-8.
10. FRISHMAN W. H., Zimetbaum P. and Nadelmann J. 1989. Lovastatin and other HMG-CoA reductase inhibitors. J. clin. Pharmacol. 29 975-82.
11. GOLDSTEIN J. L. and Brown M. S. 1990. Regulation of the mevalonate pathway. Nature 343 425-30.
12. GUNDE-CIMERMAN N. and Cimerman A. 1995. Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase lovastatin. Expl Mycol. 19 1-6.
13. GUNDE-CIMERMAN N., Friedriah J., Cimerman A. and Benicki N. 1993a. Screening fungi for the production of an inhibitor of HMG CoA reductase: production of mevinolin by the fungi of the genus Pleurotus. FEMS Microbiol. Letters 111 203-6.
14. GUNDE-CIMERMAN N., Plemenitas A. and Cimerman A. 1993b. Pleurotus fungi produce mevinolin, an inhibitor of HMG CoA reductase. FEMS Microbiol. Letters 113 333-8.
15. KUMAGAI H., Tomoda H. and Omura S. 1990. Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells. J. Antibiot. 43 397-402.
16. MONAGHAN R. L., Alberts A. W., Hoffman C. H. and Albers-Schonberg G. 1980. Hypocholesterolemic fermentation products and process of preparation. U.S. Patent 4, 231, 938.
17. 13C NMR and mass spectrometry. J. Am. chem. Soc. 107 3694-701.
18. SABRY S. A., El-Refai A. H. and Gamati S. Y. 1989. Riboflavin formation by mould fungi cultivated on hydrocarbon containing media. Microbios 57 33-40.
19. SHINDIA A. A. 1990. Studies on fungal degradation of compost in Egypt. PhD thesis. Zagazig University, Egypt.
20. SHINDIA A. A. 1995. Studies on pectin-degrading fungi in compost. Egypt. J. Microbiol. 30 85-99.