The complement regulators C1 inhibitor and soluble complement receptor 1 attenuate acute lung injury in rabbits

Shock

Volumn 13, Issue 4, 2000, Pages 285-290

  Heller, Axel ^a   Kunz, Marc ^b   Samakas, Andreas ^b   Haase, Michael ^a   Kirschfink, Michael ^c   Koch, Thea ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

ARDS; C1 inhibitor; C5b 9; Complement; sCR1

Indexed keywords

CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT; COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT RECEPTOR; SOLUBLE COMPLEMENT INHIBITOR 1; THROMBOXANE B2;

ANIMAL; ARTICLE; BLOOD PRESSURE; COMPLEMENT ACTIVATION; DRUG EFFECT; FEMALE; HUMAN; IN VITRO STUDY; LUNG; LUNG EDEMA; METABOLISM; PATHOLOGY; PERFUSION; PHYSIOLOGY; PULMONARY ARTERY; RABBIT;

ANIMALS; BLOOD PRESSURE; COMPLEMENT ACTIVATION; COMPLEMENT C1 INACTIVATOR PROTEINS; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; FEMALE; HUMANS; LUNG; PERFUSION; PULMONARY ARTERY; PULMONARY EDEMA; RABBITS; RECEPTORS, COMPLEMENT; THROMBOXANE B2;

EID: 0033643797     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200004000-00006     Document Type: Article

References (37)

1. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RMH, Sibbald WJ: Definitions of sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101:1644-1655, 1992.
2. Parillo JE, Parker MM, Natanson C, Suffredini AF, Danner RL, Cunnion RE, Ognibene FP: Septic shock in humans: advances in the understanding of the pathogenesis, cardiovascular dysfunction and therapy. Ann Intern Med 113:227-242, 1990.
3. Gama de Abreu M, Kirschfink M, Quintel M, Albrecht DM: White blood cell counts and plasma C3a have synergistic predictive value in patients at risk for acute respiratory distress syndrome. Crit Care Med 26:1040-1047, 1998.
4. Zilow G, Sturm JA, Rother U, Kirschfink M: Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndrome. Clin Exp Immunol 79:151-157, 1990.
5. Weisman HF, Bartow T, Leppo MK, Marsh HC Jr, Carson GR, Concino MF, Boyle MP, Roux KH, Weisfeldt ML, Fearon DT: Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post ischemic myocardial inflammation and necrosis. Science 249:146, 1990.
6. Kochilas L, Campbell B, Scalia R, Lefer AM: Beneficial effects of C1 esterase inhibitor in murine traumatic shock. Shock 8:165-169, 1997.
7. Carrell RW, Boswell DR: Serpins: the superfamily of plasma serine proteinase inhibitors. In: Barrett AJ, Salvesen G (eds): Proteinase inhibitors. 1990:403-420.
8. 125I-labelled complement subcomponents C1r and C1s with protease inhibitors in plasma. FEBS Lett 97:111-115, 1979.
9. Pixley RA, Shapira M, Colman RW: The regulation of human factor XIIa by plasma protease inhibitors. J Biol Chem 260:1723-1729, 1985.
10. van der Graaf F, Koedam JA, Bouma BN: Inactivation of kallikrein in human plasma. J Clin Invest 71:149-158, 1983.
11. Kirschfink M, Nünberger W: C1 Inhibitor in anti-inflammatory therapy: from animal experiment to clinical application. Mol Immunol 38:225-232, 1999.
12. Fearon DT: Anti-inflammatory and immunosuppressive effects of recombinant soluble complement receptor 1. Clin Exp Immunol 86:43-46, 1991.
13. Fearon DT: Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membranes. Proc Natl Acad Sci USA 76:5867-5871, 1979.
14. Keshavjee SH, Davis RD, Zamora MR, Schulman L, Levin J, Ryan U, Patterson GA: Inhibition of complement in human lung transplant reperfusion injury: a multicenter clinical trial (Abstract). J Heart Lung Transplant 17:43, 1998.
15. Rabinovici R, Yeh CG, Hillegass LM, Griswold DE, DiMartino MJ, Vernick J, Fong KL, Feuerstein G: Role of complement in endotoxin/platelet-activating factor-induced lung injury. J Immunol 149:1744-1750, 1992.
16. Kirschfink M: Controlling the complement system in inflammation. Immunopharmacology 38:51-62, 1997.
17. Johnson KJ, Wilson BS, Till GO, Ward PA: Acute lung injury in rat caused by imunglobulin A immune complexes. J Clin Invest 74:358-369, 1984.
18. Ognibene FP, Martin SE, Parker MM, Schlesinger T, Roach P, Burch C, Shelhamer JH, Parillo JE: Adult respiratory distress in patients with severe neutropenia. N Engl J Med 315:547-551, 1986.
19. Koch T, Duncker HP, Heller A, Schaible R, van Ackern K, Neuhof H: Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. Shock 1:146-152, 1994.
20. Heller A, Ragaller M, Schmeck J, Flüth H, Müller M, Albrecht DM, Koch T: Role of NO and endothelin-1 in hemoglobin induced pulmonary vaso-constriction. Shock 10:401-406, 1998.
21. Platt-Mills TAE, Ishizaka K: Activation of the alternate pathway of human complement by rabbit cells. J Immunol 113:348-358, 1974.
22. Nürnberger W, Heying R, Burdach S, Göbel U: C1 esterase inhibitor concentrate for capilary leakage syndrome following bone marrow transplantation. Ann Hematol 75:95-101, 1997.
23. Pratt JR, Hibbs MJ, Laver AJ, Smith RAG, Sacks SH: Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat. Am J Pathol 149: 2055-2066, 1996.
24. Heller A, Kirschfink M: Effects of C1-inhibitor and sCR-1 on complement induced lung injury (Abstract). Acta Anaesthesiol Scand 41 Suppl:100, 1997.
25. Seeger W, Hartmann R, Neuhof H, Bhakdi S: Local complement activation, thromboxane-mediated vasoconstriction, and vascular leakage in isolated lungs. Am Rev Respir Dis 139:88-99, 1989.
26. Heckl-Österreicher B, Wosnik A, Kirschfink M: Protection of porcine endothelial cells from complement-mediated cytotoxocity by the human complement regulators CD59, C1 inhibitor, and soluble complement receptor type 1. Transplantation 62:1693-1696, 1996.
27. Kotnik V, Luznik-Bufon T, Schneider PM, Kirschfink M: Molecular, genetic, and functional analysis of homozygous C8β-chain deficiency in two siblings. Immunopharmacology 38:215-221, 1997.
28. Dalmasso AP: Complement in the pathophysiology and diagnosis of human diseases. Crit Rev Clin Lab Sci 24:123-183, 1986.
29. Morgan BP: Complement. Clinical aspects and relevance to disease. London/New York: Harcourt Brace Jovanovich, 1990.
30. Yamada H, Kudon I, Nishizawa H, Kaneko K, Miyazaki H, Onara M, Okumura I: Complement partially mediates acid aspiration induced remote organ injury in the rat. Acta Anaesthesiol Scand 41:713-718, 1997.
31. Stove S, Weite T, Wagner TO, Kola A, Klos A, Bautsch W, Köhl J: Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome. Clin Diagn Lab Immunol 3:175-183, 1996.
32. Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS: Association of complement activation and elevated plamsa C5a with adult respiratory distress syndrome. Lancet 3:947-949, 1980.
33. Morganroth ML, Till Go, Kunkel RG, Ward PA: Complement and neutrophil mediated injury of perfused rat lungs. Lab Invest 54:507-514, 1986.
34. Hänsch GM, Gemsa D, Resch K: Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and channel forming antibiotic nystatin: Inhibition of the reacylation of liberated arachidonic acid. J Immunol 135:1320-1324, 1985.
35. Suttorp N, Seeger W, Zinsky S, Bhakdi S: Complement complex C5b-9 induces PGI2 formation in cultured endothelial cells. Am J Physiol 253:C13-21, 1987.
36. Seeger W, Suttorp N, Hellwig A, Bhakdi S: Non cytolytic terminal complement complexes may serve as calcium gates to elicit leukotrien B4 generation in human polymorphonuclear leukocytes. J Immunol 137: 1286-1294, 1986.
37. Fisher MB, Prodeus AP, Nicholson-Weller A, Ma M, Murrow J, Reid RR, Warren HB, Lage AL, Moore FD, Rosen FS, Carroll MC: Increaed susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement. J Immunol 159:976-982, 1997.