The effects of androgens on osteoblast function in vitro

Mayo Clinic Proceedings

Volumn 75, Issue SUPPL., 2000, Pages

  Khosla, Sundeep ^a  

^a MAYO CLINIC ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CYTOKINE; ESTROGEN; ESTROGEN RECEPTOR; GROWTH PROMOTOR;

ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CHEMISTRY; CYTOLOGY; HUMAN; OSTEOBLAST; PHYSIOLOGY; RAT; REVIEW;

ANDROGENS; ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CYTOKINES; ESTROGENS; GROWTH SUBSTANCES; HUMANS; OSTEOBLASTS; RATS; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN;

EID: 0033642679     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0025-6196(19)30643-3     Document Type: Article

References (15)

1. Eriksen EF, Colvard DS, Berg NJ, et al. Evidence of estrogen receptors in normal human osteoblast-like cells. Science. 1988; 241:84-86.
2. Colvard DS, Eriksen EF, Keeting PE, et al. Identification of androgen receptors in normal human osteoblast-like cells. Froc Natl AcadSciUSA. 1989;86:854-847.
3. Kasperk CH, Wakley GK, Hierl T, Ziegler R. Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. / Bone Miner Res. 1997; 12:464-471.
4. Benz DJ, Haussler MR, Thomas MA, et al. High affinity androgen binding and androgenic regulation of Al(I)-procollagen and transforming growth factor-beta steady state messenger ribonucleic acid levels in human osteoblast-like osteosarcoma cells. Endocrinology. 1991;128:2723-2730.
5. Hofbauer LC, Khosla S. Androgen effects on bone metabolism: recent progress and controversies. Eur J Endocrinol. 1999; 140:271-286.
6. Kasperk CH, Fitzsimmons R, Strong D, et al. Studies of the mechanisms by which androgens enhance mitogenesis and differentiation in bone cells. J Clin Endocrinol Melab. 1990;71:1322-1329.
7. Bodine PVN, Riggs BL, Spelsberg TC. Regulation of c-fos expression and TGF-b production by gonadal and adrenal androgens in normal osteoblastic cells. J Steroid Biochem Mol Biol. 1995;52:149-152.
8. Pivirotto LA, Cissel DS, Keeting PE. Sex hormones médiate interleukin-lb production by human osteoblastic HOBIT cells. Mol Cell Endocrinol. 1995;111:67-74.
9. Bellido T, Jilka RL, Boyce BF, et al. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens: the role of the androgen receptor. J Clin Invest. 1995;95:2886-2895.
10. Pilbeam CC, Raisz LG. Effects of androgens on parathyroid hormone and interleukin-1 -stimulated prostaglandin production in cultured neonatal mouse calvariae. J Bone Miner Res. 1990; 5:1183-1188.
11. Harris SA, Enger RJ, Riggs BL, et al. Development and characterization of a conditionally immortalized human fetal osteoblastic cell line. J Bone Miner Res. 1995; 10:178-186.
12. Hofbauer LC, Hicok KC, Schroeder MJ, et al. Development and characterization of a conditionally immortalized human osteoblastic cell line stably transfected with the human androgen receptor gene. J Cell Biochem. 1997;66:542-551.
13. Wiren KM, Zhang X, Chang C, et al. Transcriptional upregulation of the human androgen receptor by androgen in bone cells. Endocrinology. 1997;138:2291-2300.
14. Hofbauer LC, Ten RM, Khosla S. The anti-androgen, hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. J Bone Miner Res. 1999;14:1330-1337.
15. Gori F, Hofbauer L, Conover CA, Kholsa S. Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line. Endocrinology. 1999;140:5579-5586.