Association of AccI polymorphism in the follicle-stimulating hormone β gene with polycystic ovary syndrome

Fertility and Sterility

Volumn 74, Issue 6, 2000, Pages 1233-1236

  Tong, Yan ^a   Liao, Wu Xiang ^a   Roy, Ashim C ^a   Ng, Soon Chye ^a  

^a NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Follicle stimulating hormone gene; Obesity; Polycystic ovary syndrome; Polymorphism

Indexed keywords

FOLLITROPIN; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HIRSUTISM; HOMOZYGOSITY; HUMAN; INFERTILITY; MAJOR CLINICAL STUDY; MENSTRUATION DISORDER; OBESITY; OVARY POLYCYSTIC DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

ACNE VULGARIS; FEMALE; FOLLICLE STIMULATING HORMONE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; GENE FREQUENCY; HIRSUTISM; HOMOZYGOTE; HUMANS; MENSTRUATION DISTURBANCES; OBESITY; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, GENETIC; REFERENCE VALUES;

EID: 0033637414     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(00)01616-2     Document Type: Article

References (8)

1. Insulin, androgens, and obesity in women with and without polycystic ovary syndrome; a heterogeneous group of disorders
2. Prolonged stimulation of follicle-stimulating hormone is required for the induction of ovarian follicular cysts by human chorionic gonadotropin in hypophysectomized rats
3. Thirty-seven candidate genes for polycystic ovary syndrome; strongest evidence for linkage is with follistatin
4. Overexpression of mouse follistatin causes reproductive defects in transgenic mice
5. New AccI polymorphism in the follicle-stimulating hormone beta-subunit gene and its prevalence in three Southeast Asian populations
6. Molecular mysteries of polycystic ovary syndrome
7. Ovarian thecal/interstitial androgen synthesis is enhanced by a follicle-stimulating hormone-stimulated paracrine mechanism
8. Transgenic models to study gonadotropin function; the role of follicle-stimulating hormone in gonadal growth and tumorigenesis