The emerging role of CD40 ligand in HIV infection

Journal of Leukocyte Biology

Volumn 68, Issue 3, 2000, Pages 373-382

  Kornbluth, R S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CD40 ligand; CD4+ T cells; HIV

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN GP 39; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL MODEL; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKOCYTE ACTIVATION; MOUSE; MYCOBACTERIOSIS; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; CD40 LIGAND; HIV; HIV INFECTIONS; HUMANS; MEMBRANE GLYCOPROTEINS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033636881     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (118)

1. CD40 and its ligand in host defense
2. Immune regulation by CD40 and its ligand GP39
3. The CD40 ligand: At the center of the immune universe?
4. CD40-CD40 ligand
5. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells
6. Immunology: Licence to kill
7. CD40-CD154 interactions in B-cell signaling
8. An essential role for NF-kappaB in preventing TNF- alpha-induced cell death
9. T cell rescue of monocytes from apoptosis: Role of the CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity
10. Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor
11. TRAF6 is a signal transducer for interleukin-1
12. TRANCE is a TNF family member that regulates dendritic cell and osteoclast function
13. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF- kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
14. Association of the p75 neurotrophin receptor with TRAF6
15. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
16. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor
17. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily
18. High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization
19. The many roles of CD40 in cell-mediated inflammatory responses
20. Interaction of B cells with activated T cells reduces the threshold for CD40-mediated B cell activation
21. Structural characteristics of CD40 ligand that determine biological function
22. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
23. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
24. RANK is essential for osteoclast and lymph node development
25. Interleukin 1 is processed and released during apoptosis
26. Approaching the asymptote? Evolution and revolution in immunology
27. Tolerance, danger, and the extended family
28. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
29. + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex
30. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function
31. + T cells via CD40 ligand
32. CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses
33. Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells
34. Functional B cell abnormalities in HIV type 1 infection: Role of CD40L and CD70
35. + cells from HIV+ individuals to express CD40 ligand after in vitro stimulation is not impaired
36. Decreased CD40 ligand induction in CD4 T cells and dysregulated IL-12 production during HIV infection
37. Cutting edge: CD40 ligand is a limiting factor in the humoral response to T cell-dependent antigens
38. Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters
39. Studies of CD40L expression by lymphoid cells from experimentally and naturally SIV-infected nonhuman primate species
40. Long-term cultures of HTLV-III - Infected T cells: A model of cytopathology of T-cell depletion in AIDS
41. The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection
42. + T cells in response to antigen depends on close contact through adhesion molecules
43. CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: Role of signal transduction
44. Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficieney virus
45. Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS
46. The susceptibility to X4 and R5 human immunodeficiency virus-1 strains of dendritic cells derived in vitro from CD34(+) hematopoietic progenitor cells is primarily determined by their maturation stage
47. Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells
48. HIV-1 LTR activity in human CD40-activated B lymphocytes is dependent on NF-kappaB
49. CD40/CD40L interactions and cytokines regulate HIV replication in B cells in vitro
50. CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: Potential role of B lymphocytes as a viral reservoir
51. HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas
52. CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma
53. CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines
54. Activation of human dendritic cells through CD40 cross-linking
55. Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: Evidence for CC-chemokine-dependent and -independent mechanisms
56. Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: Implications for immunotherapy
57. CD40L activation of mononuclear phagocytes: Regulation of HIV-1 replication, beta-chemokine production, and beta-chemokine receptor expression
58. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-actirated germinal center dendritic cells
59. Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells
60. Inhibition of HIV-1 infection by the betachemokine MDC
61. Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation
62. Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human
63. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1
64. Recombinant human CD40 ligand inhibits simian immunodeficiency virus replication: A role for interleukin-16
65. Overview of interleukin-18: More than an interferon-gamma inducing factor
66. Impaired interleukin 12 production in human immunodeficiency virus-infected patients
67. The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals
68. CD40 ligand and IFN-gamma synergistically restore IL-12 production in HIV-infected patients
69. Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro
70. Interactions between interferon and the human immunodeficiency virus
71. Interferon-gamma protects primary monocytes against infection with human immunodeficiency virus type 1
72. HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)
73. Up-regulation of Type 1 interferon-inducible genes after HIV-1 rebound in persons terminating HAART
74. A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2, IL-4, and IL-10 secretion and expression of CD25, CD40L, and CD69
75. The T4 surface antigen is involved in the induction of helper function
76. Epitopes of the CD4 antigen and HIV infection
77. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
78. Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients
79. Enzyme-linked immunoassay for human immunodeficiency virus type 1 envelope glycoprotein 120
80. + cell function down-regulation in AIDS patients
81. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
82. + T cells apoptosis: A possible mechanism of bystander cell death in HIV infection
83. + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
84. Membrane tumour necrosis factor-alpha is involved in the polyclonal B-cell activation induced by HIV-infected human T cells
85. Viral immune evasion due to persistence of activated T cells without effector function
86. Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells
87. HIV-specific CD8+ T cells produce antiviral cytokines but are impaired in cytolytic function
88. + T-cell tolerance to T-cell priming through in vivo ligation of CD40
89. CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice
90. Bone marrow-derived cells are required for the induction of a pulmonary inflammatory response mediated by CD40 ligation
91. Clinical spectrum of X-linked hyper-IgM syndrome
92. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis
93. Role of CD40 ligand in Mycobacterium avium infection
94. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
95. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
96. The great escape: AIDS viruses and immune control
97. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response
98. + T cell functions
99. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection
100. Immune responses in the absence of costimulation: Viruses know the trick
101. + T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatis virus requires CD40 ligand expression, but not IFN-gamma or IL-4
102. A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response
103. OX40-ligand has a critical co-stimulatory role in dendritic cell: T cell interactions
104. OX40-deficient mice are defective in Th Cell proliferation but are competent in generating B cell and CTL responses after virus infection
105. Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion
106. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells
107. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
108. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
109. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal
110. Costimulation of CD28-T lymphocytes by 4-1BB ligand
111. + T cell responses associated with control of viremia
112. Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
113. + T cells
114. The challenge of immune control of immunodeficiency virus
115. + T-helper and a T-killer cell
116. Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against human immunodeficiency virus type-1
117. Possible role of interleukin-10 (IL-10) and CD40 ligand expression in the pathogenesis of hypergammaglobulinemia in human immunodeficiency virus infection: Modulation of IL-10 and Ig production after intravenous Ig infusion
118. Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: Possible implications for lymphocyte traffic and functional recovery