Intratumor heterogeneity of centromere numerical abnormality in multiple primary gastric cancers: Application of fluorescence in situ hybridization with intermittent microwave irradiation on paraffin-embedded tissue

Japanese Journal of Cancer Research

Volumn 91, Issue 11, 2000, Pages 1134-1141

  Kobayashi, Keiko ^a   Kitayama, Yasuhiko ^a,b   Igarashi, Hisaki ^a   Yoshino, Goro ^b   Kobayashi, Toshihiko ^a   Kazui, Teruhisa ^a   Sugimura, Haruhiko ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUJIEDA MUNICIPAL GENERAL HOSPITAL   (Japan)

Author keywords

Centromere (chromosomal) numerical abnormality; FISH; Gastric cancer; Histological heterogeneity; Hyperploidal progression

Indexed keywords

PARAFFIN;

ADULT; ARTICLE; CASE REPORT; CELL HETEROGENEITY; CENTROMERE; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 16; CHROMOSOME 18; CHROMOSOME NUMBER; CLONOGENIC ASSAY; FLUORESCENCE IN SITU HYBRIDIZATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROWAVE IRRADIATION; MULTIPLE CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOMACH CANCER; TISSUE SECTION;

CENTROMERE; CHROMOSOME ABERRATIONS; DNA, NEOPLASM; EPITHELIAL CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; MALE; MICROSATELLITE REPEATS; MICROWAVES; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; PARAFFIN EMBEDDING; STOMACH NEOPLASMS;

EID: 0033636132     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb00896.x     Document Type: Article

References (16)

1. Initial intermittent microwave irradiation for FISH analysis in paraffin-embedded tissue sections of gastrointestinal neoplasia
2. Amplification of FISH signals using intermittent microwave irradiation for analysis of chromosomal instability in gastric cancer
3. A case of multiple colorectal cancers repeatedly resected 5 times
4. Mutational analyses of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability
5. Frequent co-occurrence of mutator phenotype in synchronous, independent multiple cancers of the stomach
6. A national cancer institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
7. Numerical aberration and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: Analysis by fluorescence in situ hybridization (FISH) and PCR-SSCP
8. Interphase cytogenetics of gastric and esophageal adenocarcinomas
9. Different vulnerability among chromosomes to numerical instability in gastric carcinogenesis: Stage-dependent analysis by FISH using microwave irradiation
10. Higher frequencies of numerical aberrations of chromosome 17 in primary gastric cancers are associated with lymph node metastasis
11. Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas
12. PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo
13. DNA amplification in human gastric carcinomas
14. Genetic instability in colorectal cancers
15. Genetic instabilities in human cancers