Understanding peptide interactions with the lipid bilayer: A guide to membrane protein engineering

Current Opinion in Chemical Biology

Volumn 4, Issue 6, 2000, Pages 639-644

  Bechinger, Burkhard ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PEPTIDE;

ALPHA HELIX; BIOGENESIS; HYDROPHOBICITY; LIPID BILAYER; MEMBRANE STRUCTURE; OLIGOMERIZATION; PROTEIN FOLDING; PROTEIN LIPID INTERACTION; REVIEW; THERMODYNAMICS;

EID: 0033635131     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00143-5     Document Type: Review

References (59)

1. How many membrane proteins are there?
2. Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms
3. Membrane proteins: Structure and function
4. Transmembrane insertion of the colicin Ia hydrophobic hairpin
5. Solid-state NMR investigations on the structure and topological equilibria of polypeptides associated with biological membranes
6. Principles of membrane protein assembly and structure
7. The preference of tryptophanes for membrane interfaces
8. Architecture of helix bundle membrane proteins: An analysis of cytochrome c oxidase from bovine mitochondria
9. Architecture of β-barrel membrane proteins: Analysis of trimeric porins
10. Membrane protein folding and oligomerization: The two-stage model
11. The structure, dynamics and orientation of antimicrobial peptides in membranes by solid-state NMR spectroscopy
12. Solution structure and orientation of the transmembrane anchor domain of the HIV-1 encoded virus protein U (Vpu) by high-resolution and solid-state NMR spectroscopy
13. Membrane interactions and alignment of the structures within HIV-1 Vpu cytoplasmic domain: Effect of phosphorylation of serines 52 and 56
14. Designing transmembrane α-helices that insert spontaneously
15. De novo design of a peptide which partitions between water and phospholipid bilayers as a monomeric α-helix
16. Interaction of a peptide model of a hydrophobic transmembrane α-helical segment of a membrane protein with phosphatidylethanolamine bilayers: Differential scanning calorimetric and Fourier transform infrared spectroscopic studies
17. 31P solid-state NMR spectroscopy investigation
18. Perspective: Peptides as mimics of transmembrane segments in proteins
19. Design of model amphipathic peptides having potent antimicrobial activities
20. Peptide structural analysis by solid-state NMR spectroscopy
21. Structure, orientation and affinity for interfaces and lipids of ideally amphipathic LiKj (i=2j) peptides
22. The alignment of a voltage sensing peptide in DPC micelles and in oriented lipid bilayers by NMR and molecular modeling
23. Structure of the antimicrobial peptide tritrpticin bound to micelles: A distinct membrane-bound peptide fold
24. De novo design of integral membrane proteins
25. Mutational analysis of signal-anchor and stop-transfer sequences in membrane proteins
26. Peptide ion channels - Design and creation of function
27. The interactions of histidine-containing amphipathic helical peptide antibiotics with lipid bilayers: The effects of charges and pH
28. Towards membrane protein design: pH dependent topology of histidine-containing polypeptides
29. Hydrophobicity of amino acids in biological membranes. A solid-state NMR approach
30. Negatively charged amino acid residues play an active role in orienting the sec-independent Pf3 coat protein in the Escherichia coli inner membrane
31. Membrane protein folding and stability: Physical principles
32. The topology of lysine-containing amphipathic peptides in bilayers by CD, solid-state NMR and molecular modelling
33. De novo design, synthesis, and characterisation of a pore-forming small globular protein and its insertion into lipid bilayers
34. Amphipathic helix motif: Classes and properties
35. Positively and negatively charged residues have different effects on the position in the membrane of a model transmembrane helix
36. Helix capping
37. Binding of small basic peptides to membranes containing acidic lipids theoretical models and experimental results
38. Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles
39. Structure and dynamics of the M13 coat protein signal sequence in membranes
40. Hydrophobic mismatch between proteins and lipids in membranes
41. Helix packing in membrane proteins
42. Statistical analysis of amino acid patterns in transmembrane helices: The GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions
43. Interhelical hydrogen bonding drives strong interactions in membrane proteins
44. A leucine zipper stabilizes the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure
45. Depolymerization of phospholamban in the presence of calcium pump: A fluorescence energy transfer study
46. Internal packing of helical membrane proteins
47. Helix packing in polytopic membrane proteins: Role of glycine in transmembrane helix association
48. Asparagine-mediated self-association of a model transmembrane helix
49. Free-energy determinants of α-helix insertion into lipid bilayers
50. De novo design and structural characterization of proteins and metalloproteins
51. Turns in transmembrane helices: Determination of the minimal length of a 'helical hairpin' and derivation of a fine-grained turn propensity scale
52. Folding of beta-sheet membrane proteins - A hydrophobic hexapeptide model
53. Ideally amphipathic beta-sheeted peptides at interfaces: Structure, orientation, affinities for lipids and hemolytic activity of (KL)(m)K peptides
54. Reversible random coil-β-sheet transition of the β-amyloid fragment (23-35)
55. Development of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy
56. Crystal structure of the calcium pump of sarcoplasmatic reticulum at 2.6 A resolution
57. Bacteriorhodopsin - The movie
58. Crystal structure of rhodopsin: A G protein-coupled receptor
59. Structure of bacteriorhodopsin at 1.55 angstrom resolution