Apoptosis-inducing oxovanadium(IV) complexes of 1,10-phenanthroline against human ovarian cancer

Anti-Cancer Drugs

Volumn 11, Issue 10, 2000, Pages 849-858

  D'Cruz, Osmond J ^b   Dong, Yanhong ^b   Uckun, Fatih M ^a,b  

^a Parker Hughes Cancer Center   (United States)

^b PARKER HUGHES INSTITUTE   (United States)

Author keywords

Cisplatin; Ovarian cancer; Oxovanadium complexes; Vanadium

Indexed keywords

1,10 PHENANTHROLINE; ANTINEOPLASTIC AGENT; BROMINE DERIVATIVE; VANADIUM DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CHELATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CELL DIVISION; FEMALE; HUMANS; OVARIAN NEOPLASMS; PHENANTHROLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VANADATES;

EID: 0033634819     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200011000-00009     Document Type: Article

References (29)

1. Cancer statistics, 1997
2. Current strategies for prevention, detection, and treatment of ovarian cancer
3. Chemotherapy of ovarian cancer
4. Chemotherapy of advanced ovarian cancer
5. Non-platinum-group metal antitumor agents: History, current status, and perspectives
6. Antitumor activity and toxicity of peroxo heteroligand vanadates(V) in relation to biochemistry of vanadium
7. Cisplatin
8. Metallocene interactions with DNA and DNA-processing enzymes
9. Mechanism for a new antitumor vanadium complex: Hydroxyl radical-dependent DNA cleavage by 1,10-phenanthroline-vanadyl complex in the presence of hydrogen peroxide
10. Apoptosis-inducing vanadocene compounds against human testicular cancer
11. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
12. Antitumor activity of vanadium compounds
13. Tumor inhibition by metallocenes: Activity against leukemias and detection of the systematic effect
14. In vitro cell growth inhibition by metallocene dichlorides
15. Antitumor and toxicologic properties of the organometallic anticancer agent vanadocene dichloride
16. Transition and main-group metal cyclopentadienyl complexes: Preclinical studies on a series of antitumor agents of different structural type
17. Antitumor bis(cyclopentadienyl) metal complexes
18. Antitumor activity of new organometallic compounds in human ovarian cancer cell lines and comparison to platin derivatives
19. Peroxo heteroligand vanadates(V): Synthesis, spectra-structure relationships, and stability toward decomposition
20. Metal complexes as enzyme inhibitors
21. Spermicidal activity of oxovanadium(IV) complexes of 1,10-phenanthroline, 2,2'-bipyridyl, 5'-bromo-2'-hydroxyacetopheneone and derivatives in humans
22. Synthesis, X-ray structure, and anti-leukemic activity of oxovanadium(IV) complexes
23. DNA cleavage by hydroxyl radicals generated in a vanadyl ion-hydrogen peroxide system
24. Use of chelation agents to inhibit enzymes
25. Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound
26. P53, cell cycle control and apoptosis: Implications for cancer
27. Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways
28. Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium (IV) as a novel apoptosis-inducing anticancer agent
29. Vanadium compounds: Biological actions and potential as pharmacological agents