Expression of cathepsin B and cystatin C in the human adenohypophysis and in pituitary adenomas

Oncology Reports

Volumn 7, Issue 1, 2000, Pages 27-31

  Yoshimura, Kunikazu ^a   Tsuchida, Takahiro ^a   Kawamoto, Keiji ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Adenohypophysis; Cathepsin B; Cystatin C; Immunohistochemistry; Pituitary adenoma

Indexed keywords

CATHEPSIN B; CORTICOTROPIN; CYSTATIN; CYSTATIN C; CYSTEINE PROTEINASE INHIBITOR; PROLACTIN;

ADENOHYPOPHYSIS; ADENOMA; ARTICLE; CHEMISTRY; HUMAN; HYPOPHYSIS TUMOR; IMMUNOHISTOCHEMISTRY; SECRETION;

ADENOMA; ADRENOCORTICOTROPIC HORMONE; CATHEPSIN B; CYSTATINS; CYSTEINE PROTEINASE INHIBITORS; HUMANS; IMMUNOHISTOCHEMISTRY; PITUITARY GLAND, ANTERIOR; PITUITARY NEOPLASMS; PROLACTIN;

EID: 0033631861     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.7.1.27     Document Type: Article

References (14)

1. Katsunuma N and Kominami E: Molecular basis of intracellular regulation of thiol proteinase inhibitors. In: Current Topics in Cellular Regulation. Shaltiel S and Chock PB (eds). Academic Press Inc., pp345-360, 1985.
2. Shinagawa T, Nakayama K, Uchiyama Y, Kominami E, Doi Y, Hashiba K, Yano K, Hsueh WA and Murakami K: Role of cathepsin B as prorenin processing enzyme in human kidney. Hypertens Res 18: 131-136, 1995.
3. Neves FAR, Duncan KG and Baxter JD: Cathepsin B is a prorenin processing enzyme. Hypertension 27: 514-517, 1996.
4. Becú Villalobos D, Lacau-Mengido IM, Thyssen SM, Díaz-Torga GS and Libertun C: Effects of LHRH and ANT II on prolactin stimulation are mediated by hypophysial AT1 receptor subtype. Am J Physiol 266: E274-E278, 1994.
5. Brzin J, Popovic T and Turk V: Human cystatin, a new protein inhibitor of cysteine proteinases. Biochem Biophys Res Commun 118: 103-109, 1984.
6. Grubb A and Löfberg H: Human γ-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis. Proc Natl Acad Sci USA 79: 3024-3027, 1982.
7. Löfberg H, Grubb AO, Jörnvall H, Möller CA, Strömblad L-G and Olsson S-O: γ-trace in human pituitary adenomas. J Clin Endocrinol Metab 59: 113-118, 1984.
8. Saint-Andre JP, Rohmer V, Pinet F, Rousselet MC, Bigorgne JC and Corvol P: Renin and cathepsin B in human pituitary lactotroph cell. Histochemistry 91: 291-297, 1989.
9. Uchiyama Y, Nakajima M, Muno D, Watanabe T, Ishii Y, Waguri S, Sato N and Kominami E: Immunocytochemical localization of cathepsins B and H in corticotrophs and melanotrophs of rat pituitary gland. J Histochem Cytochem 38: 633-639, 1990.
10. Uchiyama Y, Nakajima M, Watanabe T, Waguri S, Sato N, Yamamoto M, Hashizume Y and Kominami E: Immunocytochemical localization of cathepsin B in rat anterior pituitary endocrine cells, with special reference to its co-localization with renin and prorenin in gonadotrophs. J Histochem Cytochem 39: 1199-1205, 1991.
11. Möller CA, Löfberg H, Grubb AO, Olsson S-O, Davies ME and Barrett AJ: Distribution of cystatin C (γ-trace), an inhibitor of lysosomal cysteine proteinases, in the anterior lobe of simian and human pituitary glands. Neuroendocrinology 41: 400-404, 1985.
12. Saint-Andre J-P, Rohmer V, Alhenc-Gelas F, Menard J, Bigorgne J-C and Corvor P: Presence of renin, angiotensinogen, and converting enzyme in human pituitary lactotroph cells and prolactin adenomas. J Clin Endocrinol Metab 63: 231-237, 1986.
13. Malarkey WB, Zvara BJ and de Groff VL: Angiotensin II promotes prolactin release from normal human anterior pituitary cell cultures in a calcium-dependent manner. J Clin Endocrinol Metab 64: 713-717, 1987.
14. Deschepper CF, Seidler CD, Steele MK and Gaong WF: Further studies on the localization of angiotensin-II-like immunoreactivity in the anterior pituitary gland of the male rat, comparing various antisera to pituitary to pituitary hormones and their specificity. Neuroendocrinology 40: 471-475, 1985.