A human B-cell CLL model established by transplantation of JOK-1 cells into SCID mice and an anti-leukemia efficacy of fludarabine phosphate

Oncology Reports

Volumn 7, Issue 1, 2000, Pages 33-38

  Bai, Liyan ^a   Kon, Kenji ^a   Tatsumi, Masumi ^a   Ito, Hajime ^a   Hayashi, Shigehiro ^a   Bräutigam, Matthias ^a  

^a Preclinical Development Department   (Japan)

Author keywords

Anti leukemic efficacy; Chronic lymphocytic leukemia; Fludarabine phosphate; SCID mouse; Transplantation

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; DRUG DERIVATIVE; FLUDARABINE PHOSPHATE; VIDARABINE PHOSPHATE;

ANIMAL; ARTICLE; B CELL LEUKEMIA; CANCER TRANSPLANTATION; CELL CULTURE; DISEASE MODEL; FEMALE; HUMAN; MOUSE; MOUSE MUTANT; PATHOLOGY; XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LEUKEMIA, B-CELL, CHRONIC; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; VIDARABINE PHOSPHATE;

EID: 0033631605     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.7.1.33     Document Type: Article

References (14)

1. Foon KA, Rai KR and Gale RP. Chronic lymphocytic leukemia: new insights in biology and therapy. Ann Intern Med 113: 525-539, 1990.
2. Rai KR and Han T: Prognostic factors and clinical staging I chronic lymphocytic leukemia. Hematol/Oncol Clin North Am 4: 447-456, 1990.
3. Adkins JC, Peters DH and Markham A: Fludarabine. Drugs 53: 1005-1037, 1997.
4. Gandhi V, Huang P and Plunkett W: Fludarabine inhibits DNA replication: a rationale for its use in the treatment of acute leukemias. Leuk Lymphoma 14: 3-9, 1994.
5. Huang P and Plunkett W: Action of 9-ß-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism. Mol Pharmacol 39: 449-455, 1991.
6. Brockman RW, Schabel FM and Momtgomery JA: Preliminary communications. Biologic activity of 9-ß-D-arabinofuranosyl-2-fluoroadenine, a metabolically stable analog of 9-ß-D-arabino- furanosyladenine arabinofuranosyladenine. Biochem Pharmacol. 26: 2193-2196, 1977.
7. Brockman RW, Cheng YC, Schable FM Jr and Montgomery JA: Metabolism and chemotherapeutic activity of 9-ß-D-arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase. Cancer Res 40: 3610-3615, 1980.
8. Chun HG, Leyland-Jones B and Cheson BD: Fludarabine phosphate: a synthetic purine antimetabolite. with significant activity against lymphoid malignancies. J Clin Oncol 9: 175-188, 1991.
9. Bosma GC, Custer RP and Bosma MJ: A severe combined immunodeficiency mutation in the mouse. Nature 301: 527-530, 1983.
10. Bosma MJ and Carroll AM: The SCID mouse mutant: definition, characterization and potential uses. Annu Rev Immunol 9: 323-350, 1991.
11. Flavell DJ: Modelling human leukemia and lymphoma in severe combined immunodeficient (SCID) mice: practical applications. Hematol Oncol 14: 67-82, 1996.
12. Kawata A, Han T, Dadey B, Weier H-U G, Okazaki M, Yokota S, Fukiage T, Xiao H, Block AMW, Barcos M, Henderson E, Yoshida M and Seon BK: Establishment and characterization of the tumors of chronic lymphocytic leukemia cell line in nude and SCID mice. Leuk Res 17: 883-894, 1993.
13. Zhu Z, Ghose T, Hoskin D, Lee CLY, Fernandez LA, Rowden G and Lee SHS: Inhibition of human B-cell chronic lymphocytic leukemia by a monoclonal antibody in xenograft models. Int J Cancer 56: 439-445, 1994.
14. Hummel JL, Lichty BD, Reis M, Dube I and Kamel-Reid S: Engraftment of human chronic lymphocytic-leukemia cells in SCID mice: in vivo and in vitro studies. Leukemia 10: 1370-1376, 1996.