Molecular cloning and chimerisation of CDI 315B monoclonal antibody

Pflugers Archiv European Journal of Physiology

Volumn 439, Issue 7, 2000, Pages R79-R80

  Kopitar Jerala, Nataša ^a,b   Bestagno, Marco ^b   Fan, Xiaohui ^a   Novak Despot, Djurdja ^c   Burrone, Oscar ^b   Kos, Janko ^a,d   Škrk, Janez ^e   Gubenšek, Franc ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c RUDER BO KOVI INSTITUTE   (Croatia)

^d KRKA D D   (Slovenia)

^e INSTITUTE OF ONCOLOGY   (Slovenia)

Author keywords

breast cancer; chimerisation; recombinant antibodies

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY COL 315B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B16FL CELL LINE; CHIMERA; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GENE AMPLIFICATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYBRIDOMA; MCF 7 CELL LINE; MELANOMA CELL LINE; MOLECULAR CLONING; MOUSE; MYELOMA CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA SEQUENCE; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CHIMERA; CLONING, MOLECULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MICE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033631146     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/BF03376529     Document Type: Article

References (9)

1. Beketić-Orešković L, Šarcević B, Malenica B, Novak D (1993) Imunocytochemical reactivity of a mouse monoclonal antibody CDI 315B raised against human breast carcinoma. Neoplasma 40, 69
2. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C (1991) Sequences of proteins of immunological interest. NIH Press, Bethesda, MD
3. Levy R and Miller R (1983) Biological and clinical implications of lymphocyte hybridomas: Tumor therapy with monoclonal antibodies. Annu Rev Med. 34, 107–116
4. Li E, Pedraza A, Bestagno M, Mancardi S, Sanchez R, Burrone O (1997) Mammalian cell expression of dimeric small immune proteins (SIP). Protein Engng 10, 731–736
5. LoBuglio AF, Wheeler RH, Trang J, Haynes A, Rogers K, Harvey EB, Sun L, Ghrayeb J, Khazaeli MB, (1989) Mouse/human chimeric monoclonal antibody in man: kinetics and immune response. Proc Natl Acad Sci USA 86, 4220–4224
6. Morrison SL, Johnson MJ, Herzenberg LA, Oi VT (1984) Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. USA. 81, 6851–6855
7. Neuberger MS, Williams GT, Mitchell EB, Jouhal SS, Flanagan JG, Rabbitts TH. (1985) A hapten-specific chimaeric IgE antibody with human physiological effector function. Nature 314, 268–270
8. Novak-Despot D, Kos J, Serša G, Čemažar M, Škik J, Gubenšek F (1987) Boronated CDI 315B monoclonal antibody and its potential use in boron neutron captire therapy. Advances in Neutron Capture Therapy. Vol II. 516–518
9. Tao MH, Morrison SL (1989) Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region. J Immunol 143, 2595–2601