Deletion/insertion polymorphism in the angiotension — converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease

Pflugers Archiv European Journal of Physiology

Volumn 439, Issue 7, 2000, Pages R40-R41

  Peterlin, Borut ^a   Petrovič, Daniel ^a,b   Zorc, Metka ^b   Keber, Irena ^a  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

angiotensin converting enzyme; coronary heart disease; genetic polymorphism; risk factor

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ACE GENE; ADULT; AGE; ARTICLE; ATHEROGENESIS; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY RISK; DIABETES MELLITUS; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HIGH RISK POPULATION; HUMAN; HYPERTENSION; INDEL MUTATION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MUTATIONAL ANALYSIS; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SLOVENIAN (CITIZEN); SMOKING; CORONARY ARTERY DISEASE; GENE DELETION; GENETIC PREDISPOSITION; GENETICS; REFERENCE VALUE; RISK; SLOVENIA; TRANSPOSON;

CORONARY DISEASE; DNA TRANSPOSABLE ELEMENTS; FEMALE; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; REFERENCE VALUES; SLOVENIA;

EID: 0033629953     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/BF03376516     Document Type: Article

References (10)

1. Abbud ZA, Wilson AC, Cosgrove NM, Kostis JB. Angiotensinconverting enzyme gene polymorphism in systemic hypertension. Am J Cardiol 1998; 81:224–226
2. Agerholm-Larsen B, Tyberg-Hansen A, Frikke-Schidt R et al. ACE polymorphism as risk factor for ischemic cerebrovascular disease. Ann Intern Med 1997; 127:346–355
3. Cambien F, Poirier O, Lacerf L. et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction 1992; 359:641–644
4. Kim DK, Kim JW, Kim S et al. Polymorphism of angiotensin converting enzyme gene is associated with circulating levels of plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 1997; 17:3242–3247
5. Kario K, Matsuo T, Kobayashi H et al. Endothelial cell damage and angiotensin-converting enzyme insertion/deletion genotype in elderly hypertensive patients. J Am Coll Cardiol 1998; 32:444–450
6. Margaglione M, Celentano E, Grandone E et al. Deletion polymorphism in the angiotensin-converting enzyme in patients with a history of ischemic stroke. Arterioscler Thromb Vasc Biol 1996; 16: 304–309
7. Petrovič D, Keber I, Zorc M, Peterlin B. I/D polymorphism at the locus for ACE and Apo A-I gene promoter polymorphism as risk factors for coronary artery disaese in patients with familial hypercholesterolemia. Eur J Physiol 1996; 431(Suppl):R197–198
8. Pfohl M, Athananasiadis A, Koch M et al. Insertion/deletion polymorphism of the angiotensin I — converting enzyme gene is associated with coronary artery plaque calcification as assesed by intravascular ultrasound. J Am Coll Cardiol 1998; 31:987–991
9. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soulier F. An insertion/deletion polymorphism in angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86:1343–1346
10. Samani NJ Thompson JR, O’Toole L et al. A meta-analysis of the asociation of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. Circulation 1996;94:708–12