TGF-β activates genes identified by differential mRNA display in pancreatic rudiments

Pflugers Archiv European Journal of Physiology

Volumn 439, Issue 7, 2000, Pages R26-R28

  Tadej, Battelino ^a   Francisco, Miralles ^b   Ciril, Kržišnik ^a   Raphaël, Scharfmann ^b   Paul, Czernichow ^b  

^a University Children s Hospital   (Slovenia)

^b HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

B carboxypeptidase; differential mRNA display; glucagon; pancreatic development; TGF

Indexed keywords

ALPHA TROPOMYOSIN; CARBOXYPEPTIDASE B; COMPLEMENTARY DNA; GLUCAGON; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE SEQUENCE; IMMUNOHISTOCHEMISTRY; MESENCHYME; NONHUMAN; NORTHERN BLOTTING; PANCREAS; PRIMORDIUM; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; EMBRYO; GENE EXPRESSION REGULATION; GENETICS; INFORMATION PROCESSING; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ANIMALS; DATA DISPLAY; DNA, COMPLEMENTARY; EMBRYO; GENE EXPRESSION REGULATION; PANCREAS; RATS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033629026     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/BF03376510     Document Type: Article

References (8)

1. Slack JM (1995) Developmental biology of the pancreas. Development 121:1569–1580
2. Dahl U, Sjodin A, Semb H (1996) Cadherins regulate aggregation of pancreatic beta-cells in vivo. Development 122:2895–2902
3. Miralles F, Czernichow P, Scharfmann R (1998) Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 125:1017–1024
4. Bottinger EP, Jakubczak JL, Roberts IS, et al. (1997) Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas. EMBO J 16:2621–2633
5. Sanvito F, Herrera PL, Huarte J, et al. (1994) TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 120:3451–3462
6. Ferrer J, Wasson J, Schoor KD, Mueckler M, Donis-Keller H, Permutt MA (1997) Mapping novel pancreatic islet genes to human chromosomes. Diabetes 46:386–392
7. Atouf F, Czernichow P, Scharfmann R (1997) Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer. J Biol Chem 272:1929–1934
8. Miralles F, Battelino T, Czernichow P, Scharfmann R (1998) TGF-beta plays a key role in the morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2. J Cell Biol 143:827–836