Apolipoprotein E ε4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology

Experimental Neurology

Volumn 163, Issue 2, 2000, Pages 452-456

  Pickering Brown, Stuart M ^a   Owen, Frank ^a   Isaacs, Adrian ^a   Snowden, Julie ^b   Varma, Anoop ^b   Neary, David ^b   Furlong, Robert ^c   Daniel, Susan E ^d   Cairns, Nigel J ^e   Mann, David M A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Apolipoprotein E gene; Corticobasal degeneration; Frontotemporal dementia; Motor neurone disease dementia; Progressive supranuclear palsy; 4 allele

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

ADULT; AGED; ALLELE; ARTICLE; CHI SQUARE DISTRIBUTION; DEMENTIA; FEMALE; GENETICS; HUMAN; MALE; MIDDLE AGED; ONSET AGE; PICK PRESENILE DEMENTIA; CORTICOBASAL DEGENERATION; DISEASE DURATION; FRONTOTEMPORAL DEMENTIA; GENE FREQUENCY; GENETIC POLYMORPHISM; HISTOPATHOLOGY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PYRAMIDAL NERVE CELL;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALLELES; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CHI-SQUARE DISTRIBUTION; DEMENTIA; FEMALE; HUMANS; MALE; MIDDLE AGED; PICK DISEASE OF THE BRAIN;

EID: 0033625714     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7387     Document Type: Article

References (42)

1. Baker M., Kwok J. B. J., Kucera S., Crook R., Farrer M., Houlden H., Isaacs A., Lincoln S., Hardy J., Wittenberg L., Dodd P., Webb S., Hayward N., Tannenberg T., Andreadis A., Hallup M., Schofield P., Dark F., Hutton M. Localization of frontotemporal dementia with Parkinsonism in an Australian kindred to chromosome 17q21-22. Ann. Neurol. 42:1997;794-798.
2. Bird T. D., Wijsman E. M., Nochlin D., Leehey M., Sumi S. M., Payami H., Poorkaj P., Nemens E., Rafkind M., Schellenberg G. D. Chromosome 17 and hereditary dementia: Linkage studies in three non-Alzheimer families and kindreds with late onset FAD. Neurology. 48:1997;949-954.
3. Brown J., Ashworth A., Gydesen S., Sorensen A., Rossor M. N., Hardy J., Collinge J. Familial non-specific dementia maps to chromosome 3. Hum. Mol. Genet. 4:1995;1625-1628.
4. Brun A., Englund E., Gustafson L., Passant U., Mann D. M. A., Neary D., Snowden J. S. Clinical, neuropsychological and neuropathological criteria for fronto-temporal dementia. J. Neurol. Neurosurg. Psychiatr. 57:1994;416-418.
5. Clark L. N., Poorkaj P., Wszolek Z., Geschwind D. H., Nasreddine Z. S., Miller B., Li D., Payami H., Awert F., Markopoulou K., Andreadis A., D'Souza I., M.-Y. V., Reed L., Trojanowski J. Q., Zhukareva V., Bird T., Schellenberg G., Wilhelmsen K. C. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc. Natl. Acad. Sci. USA. 95:1998;13103-13107.
6. Corder E. H., Saunders A. M., Strittmatter W. J., Schmechel D. E., Gaskell P. C., Small G. W., Roses A. D., Haines J. L., Pericak-Vance M. A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
7. Czech C., Forstl H., Monning U., Kreger S., Tienari P. J., Masters C. L., Beyreuther K. ApoE4 in clinically diagnosed Alzheimer's disease, frontal lobe degeneration and non-demented controls. Neurobiol. Aging. 15:1994;S132.
8. Farrer L. A., Abraham C. R., Volicer L., Foley E. J., Kowall N. W., McKee A. C., Wells J. M. Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease. Exp. Neurol. 136:1995;162-170.
9. Feany M. B., Dickson D. W. Neurodegenerative disorders with extensive tau pathology: A comparative study and review. Ann. Neurol. 40:1996;139-148.
10. Gomez-Isla T. H., West L., Rebeck G. W., Harr S. D., Growden J. H., Locascio J. J., Perls T. T., Lipsitz L. A., Hyman B. T. Clinical and pathological correlates of Apolipoprotein E ε4 in Alzheimer's disease. Ann. Neurol. 39:1996;62-70.
11. Govoni S., Frisoni G. B., Calabresi L., Geroldi C., Bianchetti A., Trabucchi M., Franceschini G. Apolipoprotein E E4 allele frequency in non-Alzheimer dementias. Neurobiol. Aging. 15:1994;S44.
12. Hardy J., Houlden H., Collinge J., Kennedy A., Newman S., Rossor M., Lannfelt L., Lilius L., Winblad B., Crook R., Duff K. Apolipoprotein E genotype and Alzheimer's disease. Lancet. 342:1993;737-738.
13. Heutink P., Stevens M., Rizzu P., Bakker E., Kros J. M., Tibben A., Niermeijer M. F., van Duijn C. M., Oostra B. A., van Swieten J. C. Hereditary frontotemporal dementia is linked to chromosome 17q21-q22, A genetic and clinicopathological study of three Dutch families. Ann. Neurol. 41:1997;150-159.
14. Houlden H., Rizzu P., Stevens M., de Knijff P., van Duijn C. M., van Swieten J. C., Heutink P., Perez-Tur J., Thomas V., Bajer M., Morris H., Rossor M., Jannsen J. C., Petersen R. C., Dodd P., Dark F., Boeve B., Dickson D., Davies P., Pickering-Brown S., Mann D., Adamson J., Lynch T., Payami H., Poorkaj P., Bird T. D., Schellenberg G. D., Chakraverty S., Norton J., Morris J. C., Goate A., Hutton M., Hardy J. Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neurosci. Lett. 260:1999;193-195.
15. Hutton M., Lendon C. L., Rizzu P., Baker M., Froelich S., Houlden H., Pickering-Brown S., Chakraverty S., Isaacs A., Grover A., Hackett J., Adamson J., Lincoln S., Dickson D., Davies P., Petersen R. C., Stevens M., de Graaff E., Wauters E., van Baren J., Hillebrand M., Joosse M., Kwon J. M., Nowotny P., Che L. K., Norton J., Morris J. C., Reed L. A., Trojanowski J., Basun H., Lannfelt L., Neystat M., Fahn S., Dark F., Tannenberg T., Dodd P. R., Hayward N., Kwok J. B. J., Schofield P. R., Andreadis A., Snowden J., Craufurd D., Neary D., Owen F., Oostra B. A., Hardy J., Goate A., van Swieten J., Mann D., Lynch T., Heutink P. Association of missense and 5-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 393:1998;702-705.
16. Jackson M., Lennox G., Lowe J. Motor neurone disease-inclusion dementia. Neurodegeneration. 5:1996;339-350.
17. Lendon C. L., Lynch T., Norton J., McKeel D. W., Busfield F., Craddock N., Chakraverty S., Gopalakrishnan G., Shears S. D., Grimmett W., Wilhelmsen K. C., Hansen L., Morris J. C., Goate A. M. Hereditary dysphasic disinhibition dementia: A frontotemporal dementia linked to 17q21-22. Neurology. 50:1998;1546-1555.
18. Litvan I., Agid Y., Goetz C., Jankovic J., Wenning G. K., Brandel J. P., Lai E. C., Verny M., Ray-Chaudhuri K., McKee A., Jellinger K., Pearce R. K. B., Bartko J. J. Accuracy of the clinical diagnosis of corticobasal degeneration: A clinicopathological study. Neurology. 48:1997;119-125.
19. Mann D. M. A., South P. W., Snowden J. S., Neary D. Dementia of frontal lobe type: Neuropathology immunohistochemistry. J. Neurol. Neurosurg. Psychiatr. 56:1993;605-614.
20. Minthon L., Hesse C., Sjogren M., Englund E., Gustafson L., Blennow K. The apolipoprotein ε4 allele frequency is normal in fronto-temporal dementia, but correlates with age at onset of disease. Neurosci. Lett. 226:1997;65-67.
21. Morris H. R., Perez-Tur J., Janssen J. C., Brown J., Lees A. J., Wood N. W., Hardy J., Hutton M., Rossor M. N. Mutation in the tau Exon 10 splice site region in familial frontotemporal dementia. Ann. Neurol. 45:1999;270-271.
22. Murrell J., Koller D., Foroud T., Goedert M., Spillantini M. G., Edenberg H., Farlow M., Ghetti B. Familial multiple system tauopathy with presenile dementia localized to chromosome 17. Am. J. Hum. Genet. 61:1997;1131-1138.
23. Nacmias B., Latorraca S., Piersanti P., Forleo P., Piacentini S., Bracco L., Amaducci L., Sorbi S. B. ApoE genotype and familial Alzheimer's disease: a possible influence on age at onset in APP717 Val → Ile mutated families. Neurosci. Lett. 221:1995;81-84.
24. Neary D., Snowden J. S., Mann D. M. A. The clinical pathological correlates of lobar atrophy. A review. Dementia. 4:1993;154-159.
25. Petersen R. B., Tabaton M., Chen S. G., Monari L., Richardson S. L., Lynch T., Manetto V., Lanska D. J., Markesberry W. R., Currier R. D., Autilio-Gambetti L., Wilhelmsen K. C., Gambetti P. Familial Progressive subcortical gliosis: Presence of prions and linkage to chromosome 17. Neurology. 45:1995;1062-1067.
26. Pickering-Brown S. M., Roberts D., Owen F., Neary D. Apolipoprotein E4 alleles and non-Alzheimer's disease forms of dementia (letter to the editor). Neurodegeneration. 3:1994;95-96.
27. Pickering-Brown S. M., Siddons M., Mann D. M. A., Owen F., Neary D., Snowden J. Apolipoprotein E allelic frequencies in patients with lobar atrophy. Neurosci. Lett. 188:1995;205-207.
28. Poorkaj P., Bird T., Wijsman E., Nemens E., Garruto R. M., Anderson L., Andreadis A., Wiederholt W. C., Raskind M., Schellenberg G. D. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann. Neurol. 43:1998;815-825.
29. Rizzu P., Van Swieten J. C., Joosse M., Hasegawa M., Stevens M., Tibben A., Niermeijer M. F., Hillebrand M., Ravid R., Oostra B. A., Goedert M., van Duijn C. M., Heutink P. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. Am. J. Hum. Genet. 64:1999;414-421.
30. Schneider J. A., Gearing M., Robbins R. S., de l' W., Mirra S. S. Apolipoprotein E genotype in diverse neurodegenerative disorders. Ann. Neurol. 38:1995;131-135.
31. Snowden J. S., Neary D., Mann D. M. A. Fronto-Temporal Lobar Degeneration: Fronto-Temporal Dementia, Progressive Aphasia, Semantic Dementia. 1996;Churchill Livingstone, Edinburgh. p. 1-227.
32. Snowden J. S., Neary D., Mann D. M. A., Goulding P. J., Testa H. J. Progressive language disorder due to lobar atrophy. Ann. Neurol. 31:1992;174-183.
33. Snowden J. S., Griffiths H., Neary D. Semantic dementia: autobiographical contribution to preservation of meaning. Cogn. Neuropsychol. 11:1994;256-288.
34. Spillantini M. G., Goedert M., Crowther R. A., Murrell J. R., Farlow M. R., Ghetti B. Familial multiple system tauopathy: a new degenerative disease of the brain with tau neurofibrillary pathology. Proc. Natl. Acad. Sci. USA. 94:1997;4113-4118.
35. Spillantini M. G., Murrell J. R., Goedert M., Farlow M. R., Klug A., Ghetti B. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc. Natl. Acad. Sci. USA. 95:1998;7737-7741.
36. Stevens M., van Duijn C. M., de Knijff P., van Broeckhoven C., Heutink P., Oostra B. A., Niermeijer M. F., van Swieten J. C. Apolipoprotein E gene and sporadic frontal lobe dementia. Neurology. 48:1997;1526-1529.
37. St-George Hyslop P., Crapper-McLachlan D., Tuda T., Rogaev E., Karlinsky H., Lippa C. F., Pollen D. Alzheimer's disease and possible gene interaction. Science. 263:1994.
38. Tabaton, M., M. Rolleri, P. Masturzo, S. Cammarata, G. Angelini, L. A. Hansen, T. Saitoh, R. B. Petersen, G. Perry, P. Richey, P. Gambetti, and S. Bertolini. 1995. Neurology45:1764-1765.
39. Wenham P. R., Price W. H., Blundell C. Apolipoprotein E genotyping by one-stage PCR. Lancet. 337:1991;1158-1159.
40. Wijker M., Wszolek Z. K., Wolters E. C. M., Rooimans M. A., Pals G., Pfeiffer R. F., Lynch T., Rodnitzky R. L., Wilhelmsen K. C., Arwert F. Localization of the gene for rapidly progressive autosomal dominant Parkinsonism and dementia with pallido-ponto-nigral degeneration to chromosome 17q21. Hum. Mol. Genet. 5:1996;151-154.
41. Wilhelmsen K. C., Lynch T., Pavlou E., Nygaard T. G. Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22. Am. J. Hum. Genet. 55:1994;1159-1165.
42. Yamaoka L. H., Welsh-Bohmer K. A., Hulette C. M., Gaskell P. C., Murray M., Rimmler J. L., Helms B. R., Guerra M., Roses A. D., Schmechel D. E., Pericak-Vance M. A. Linkage of frontotemporal dementia to chromosome 17: Clinical and neuropathological characterization of phenotype. Am. J. Hum. Genet. 59:1996;1306-1312.