α1-microglobulin as a marker of proximal tubular damage in urinary tract infection in children

Clinical Nephrology

Volumn 53, Issue 4, 2000, Pages 283-287

  Mantur, M ^a   Kemona, H ^a   Dabrowska, M ^a   Dabrowska, J ^b   Sobolewski, S ^b   Prokopowicz, J ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b District General Hospital Bialystok   (Poland)

Author keywords

1 microglobulin; Tubular proteinuria; Urinary tract infection

Indexed keywords

ALPHA 1 MICROGLOBULIN; ALPHA GLOBULIN; ALPHA-1-MICROGLOBULIN; BIOLOGICAL MARKER; PROTEINASE INHIBITOR;

ARTICLE; CHILD; CONTROLLED STUDY; CREATININE CLEARANCE; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; MAJOR CLINICAL STUDY; MALE; PROTEIN URINE LEVEL; URINARY TRACT INFECTION; KIDNEY DISEASE; PRESCHOOL CHILD; PROSPECTIVE STUDY; URINE;

ALPHA-GLOBULINS; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MALE; PROSPECTIVE STUDIES; PROTEASE INHIBITORS; URINARY TRACT INFECTIONS;

EID: 0033625520     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Donaldson MD, Chamber RE, Woolridge MW, Whicher JT 1990 α1-Microglobulin, β2-microglobulin and retinol-binding protein in childhood febrile illnes and renal disease. Pediatr Nephrol 4: 314-318
2. Everaert K, Delanghe J, Viele ChV, Hoebeke P, Dierckx RA, Clarysse B, Lameire N, Oosterlinck W 1998 Urinary α1-microglobulin detects uropathy. A prospective study in 483 urological patients. Clin Chem Lab Med 36: 309-315
3. Elo J, Tallgren LG, Väisänen V, Korhonen TK, Svenson SB, Mäkelä PH 1985 Association of P and other fimbriae with clinical pyelonephritis in children. Scand J Urol Nephrol 19: 281-289
4. Grubb AO, Lopez C, Tejler L, Mendez E 1983 Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration. J Biol Chem 10: 14698-707
5. Grubb A 1992 Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol 38: 20-27
6. Guder W, Hofmann W 1992 Markers for the diagnosis and monitoring of renal tubular lesions. Clin Nephrol 38: 3-7
7. Johnson JR, Roberts PL, Stamm WE 1987 P-fimbriae and other virulence factors in Escherichia coli urosepsis: association with patients characteristics. J Infect Dis 156: 225-232
8. Jung K 1994 Urinary enzymes and low molecular weight proteins as markers of tubular dysfunction. Kidney Int Suppl 47: 29-33
9. Kotwal GJ 1997 Microorganisms and their interaction with the immune system. J Leuc Biol 62: 415-429
10. Latham RH, Stamm WE 1984 Role of fimbriated Escherichia coli in urinary tract infection in adult women: correlation with localization studies. J Infect Dis 149: 835-841
11. Maeda H 1996 Role of microbial proteases in pathogenesis. Microbiol Immunol 40: 685-699
12. Miettinen N, Vuopio-Varcila J, Varkila K 1996 Production of tumor necrosis factor alpha, interleukin-6 and interleukin 10 is induced by lactic acid bacteria. Infect Immun 64: 5403-5405
13. Molitoris BA, Wagner MC 1996 Surface membrane polarity of proximal tubular cells: Alterations as a basis for malfunction. Kidney Int 49: 1592-1597
14. Oberbauer R, Haas M, Mayer G 1996 Proteinuria as a consequence of altered glomerular perm selectivity - clinical implications. Clin Nephrol 46: 357-361
15. Roberts JA 1996 Tropism in bacterial infections: urinary tract infections. J Urol 156: 1552-1559
16. Sundin DP, Meyer C, Dahl R, Geerdes A, Sandoval R, Molitoris BA 1997 Cellular mechanism of aminoglicoside tolerance in long-term gentamicin treatment. Am J Physiol 272: 1309-1318
17. Thomas L 1992 Labor und Diagnose (4th ed). Die Medizinische Verlagsgesellschaft, pp 470-470
18. Tsukahara H, Hiraoka M, Kuriyama M, Haruki S, Nakamura K, Suehiro F, Sudo M 1993 Evaluation of proximal tubular function in preterm infants by urinary α1-microglobulin. Acta Pediatr JPN 35: 127-129
19. Wang Y, Chen J, Chen L, Tay YCh, Rangan GK, Harris DC 1997 Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein. J Am Soc Nephrol 1: 1527-1545
20. Weber MH, Verwiebe R 1992 α1-microglobulin (protein HC): features of a promising indicator of proximal tubular dysfunction. Eur J Clin Chem Clin Biochem 30: 683-691
21. Wijesekera DS, Zarama MJ, Paller MS 1997 Effects of integrinson proliferation and apoptosis of renal epithelial cells after acute injury. Kidney Int 52: 1511-1520
22. Zoller G, Wiedemann G, Kallerhoff M, Zappel H, Weber MH, Ringert RH 1997 Microproteinuria and enzymuria in fever and pyelonephritis in childhood. A prospective study of 180 children. Urology A 36: 68-76