Augmented prostaglandin E2 generation resulting from increased activities of cytosolic and secretory phospholipase A2 and induction of cyclooxygenase-2 in interleukin-1β-stimulated rat calvarial cells during the mineralizing phase

Inflammation Research

Volumn 49, Issue 3, 2000, Pages 102-111

  Higashi, S ^a,b   Ohishi, H ^a   Kudo, I ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Cyclooxygenase 2; Osteoblast; Phospholipase A2; Primary culture; Prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; ARACHIDONIC ACID; CYCLOOXYGENASE 2 INHIBITOR; INTERLEUKIN 1; ISOENZYME; ISOMERASE; PHOSPHOLIPASE A; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; CALVARIA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; NONHUMAN; OSTEOBLAST; PROSTAGLANDIN SYNTHESIS; RAT; ANIMAL; BIOSYNTHESIS; CELL AGING; CELL CULTURE; CYTOLOGY; CYTOSOL; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SECRETION; SKULL; WISTAR RAT;

ANIMALS; ARACHIDONIC ACID; CALCIFICATION, PHYSIOLOGIC; CELL AGING; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOSOL; DINOPROSTONE; ENZYME ACTIVATION; ENZYME INDUCTION; INTERLEUKIN-1; INTRAMOLECULAR OXIDOREDUCTASES; ISOENZYMES; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; SKULL;

EID: 0033625346     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050566     Document Type: Article

References (27)

1. [1] Dennis EA. The growing phospholipase A2 superfamily of signal transduction enzymes. Trends Biochem Sci 1997; 22: 1-2.
2. 2 gene family in mammals. J Biol Chem 1997; 272: 17247-50.
3. [3] Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996; 271: 33157-60.
4. 2 in mouse bone marrow-derived mast cells. J Biol Chem 1994; 269: 22269-75.
5. 2 in activated mast cells. J Biol Chem 1997; 272: 3231-237.
6. 2 does not alter leukotriene formation. J Biol Chem 1997; 272: 759-65.
7. 2. Proc Natl Acad Sci USA 1998; 95: 7951-6.
8. 2 generation in rat 3Y1 fibroblasts. J Biol Chem 1998; 273: 1733-40.
9. 2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochem Biophys Res Commun 1997; 230: 110-4.
10. 2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages. J Immunol 1998; 160: 2974-82.
11. 2 induction in neonatal mouse parietal bone cultures. J Bone Miner Res 1996; 11: 358-66.
12. 2 synthesis in mouse osteoblasts cultured with interleukin-1. J Biol Chem 1997; 272: 5952-8.
13. 2 from fetal rat calvarial cells in vitro: relationship to bone nodule formation. J Bone Miner Res 1991; 6: 843-50.
14. 2. J Biol Chem 1997; 272: 19891-7.
15. 2 enzymes present in P388D1 macrophages. J Biol Chem 1996; 271: 6758-65.
16. 2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Arthritis Rheum 1994; 37: 653-61.
17. 2 formation. J Biol Chem 1998; 271: 31496-501.
18. 2. Nat Struct Biol 1995; 2: 458-65.
19. 1 response in a selected population of bone cells after repeated subculture and storage at -80°C. Endocrinology 1977; 100: 1233-41.
20. [20] Drury RAB, and Wallington EA (1967) Carleton's Histological Technique. In: Carleton's Histological Technique, Fourth, Oxford University Press, Toronto, pp. 244-5.
21. [21] Marusic A, Kalinowski JF, Harrison JR, Centrella M, Raisz LG, Lorenzo JA. Effects of transforming growth factor-β and IL-1α on prostaglandin synthesis in serum-deprived osteoblastic cells. J Immunol 1911; 146: 2633-8.
22. [22] Reiser CO, Marx M, Hoppe J, Goppelt-Struebe M. Modulation of prostaglandin G/H synthase expression in mesangial cells transfected by pp60c-src proto-oncogene. Exp Cell Res 1996; 222: 304-11.
23. [23] Buchmuller-Rouiller U, Betz-Corradin S, Mauel J. Differential effects of prostaglandins on macrophage activation induced by calcium ionophore A23187 or IFN-gamma. J Immunol 1992; 148: 1171-75.
24. 2 in cultured neonatal mouse calvariae. Endocrinology 1994; 135: 1157-64.
25. [25] Pilbeam CC, Kawaguchi H, Hakeda Y, Voznesensky O, Alander CB, Raisz LG. Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. J Biol Chem 1993; 268: 25643-9.
26. [26] Pilbeam CC, Raisz LG, Voznesensky O, Alander CB, Delman BN, Kawaguchi H. Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. J Bone Miner Res 1995; 10: 406-14.
27. 2 generation in mouse bone marrow-derived mast cells. J Biol Chem 1996; 271: 25936-44.