Teratogenic and fetal toxity following intravenous theophylline administration in pregnant rabbits is related to maternal drug plasma levels

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 2, 2000, Pages 101-107

  Shibata, M ^a,d   Wachi, M ^a   Kawaguchi, M ^a   Kojima, J ^b   Onodera, K ^c  

^a Nikken Chemicals Co Ltd   (Japan)

^b Nikken Chemicals Co Ltd   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d Toxicology Group   (Japan)

Author keywords

Rabbits; Reproduction; Teratogenesis; Theophylline; Toxicokinetics

Indexed keywords

THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DRUG BLOOD LEVEL; ENVIRONMENTAL EXPOSURE; FETUS OUTCOME; MATERNAL PLASMA; NONHUMAN; RABBIT; TERATOGENICITY; ANIMAL; BLOOD; BODY WEIGHT; BONE; CONGENITAL MALFORMATION; DRUG EFFECT; EATING; FEMALE; FETUS; INTRAVENOUS DRUG ADMINISTRATION; MALE; PREGNANCY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BODY WEIGHT; BONE AND BONES; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; FETUS; INJECTIONS, INTRAVENOUS; MALE; PREGNANCY; RABBITS; THEOPHYLLINE;

EID: 0033625250     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.2.796072     Document Type: Article

References (18)

1. Aminophylline, In: The Japanese Pharmacopoeia, 13th Ed. Society of Japanese Pharmacopoeia. Hirokawa Publishing Co.: Tokyo 1996, 432-4.
2. Elias, J.A., Levinson, A.I. Hypersensitivity reactions to ethylenediamine in aminophylline. Am Rev Respir Dis 1981, 123: 550-2.
3. Thompson, P.J., Gibb, W., Cole, P., Citron, K.M. Generalised allergic reactions to aminophylline. Thorax 1984, 39: 600-3.
4. Terzian, C.G., Simon, P.A. Aminophylline hypersensitivity apparently due to ethylenediamine. Annals Emergency Med 1992, 21: 312-7.
5. Seratin, W. E. Drugs used in the treatment of asthma. In: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Ed. Gilman, A.G. (Ed.). McGraw-Hill Inc.: New York 1996, 673-5.
6. Perry, A.G. Aminophylline use in the critically ill: An old ally or new foc? AACN Clin Issues 1995, 6: 297-306.
7. Kojima, J., Katoh, H., Taniguehi, T., Kawai, H., Fukui, H., Ohnishi, A., Onodera, K. Uselfuness and safety of theophylline infection form (Theodrip®) for the treatment of acute asthma. Methods Find Exp Clin Pharmacol 2000, in press.
8. Tucci, S.M., Skalko, R.G. The teratogenic effects of theophylline in mice. Toxicol Lett 1978, 1: 337-41.
9. Fujii, T., Nishimura, H. Teratogenic actions of some methylated xanthines in mice. Okajimas Folia Anat Jpn 1969, 46: 167-75.
10. Georges, A., Denef. J. Les anomalies digitales: Manisfestations teratogeniques des derives xanthiques chez le rat. Arch Int Pharmacodyn 1968, 172: 219-22.
11. Dawson, A. B. A note on the staining of the skeleton of cleared specimens with alizarin red S. Stain Technology 1926, 1: 123-4.
12. Kawai, H., Igawa, T., Kokubo, S., Matumoto, T., Kojima, J., Onodera, K. Pharmacokinetic study of theophylline in dogs after intravenous administration of theophylline with and without ethylenediamine. Methods Find Exp Clin Pharmacol 2000, in press.
13. Brashear, R.E. Veng-Pedersen, P., Rhodes, M.L., Smith, C.N. Theophylline climination in the pregnant and fetal rabbit. J Lab Clin Med 1982, 100: 15-25.
14. Labovitz, E., Spector, S. Placental theophylline transfer in pregnant asthmatics. JAMA 1982, 247: 786-8.
15. Horimoto, M., Ariyuki, F., Daidohji, S., Fujii, T. et al. Terminology of developmental abnormalities in common laboratory mannuals (Japanese version 1). Cong Anom 1998, 38: 153-237.
16. Morita, H., Ariyuki, F., Inomata, N., Nishimura, K., et al. Spontaneous malformations in laboratory animals: Frequency of external, internal and skeletal malformation in rats, rabbits and mice. Cong Anom 1987, 27: 147-206.
17. Kaufman, D.W. Caffeine and other xanthine derivatives In: Birth Defects and Drugs in Pregnancy. Publishing Sciences Group Inc.: Massachusetts 1977, 366-70.
18. Butler, J.P. Theophylline. In: Drugs in Pregnancy and Lactation, 3rd Ed. Williams & Wilkins: Maryland 1990, 597-600.