Th1/Th2 cytokines and ICAM-1 levels post-liver transplant do not predict early rejection

Mediators of Inflammation

Volumn 9, Issue 1, 2000, Pages 35-38

  Granot, E ^a,b   Tarcsafalvi, A ^a,b   Emre, S ^a,b   Sheiner, P ^a,b   Guy, S ^a,b   Schwartz, M E ^a,b   Boros, P ^a,b   Miller, C M ^a,b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

ICAM 1; Immunosuppression; Liver transplant; Rejection; Th1 Th2 cytokines

Indexed keywords

CYCLOSPORIN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; OKT 3;

ADULT; ARTICLE; CLINICAL ARTICLE; CYTOKINE RELEASE; FEMALE; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL; BLOOD; IMMUNOLOGY; MIDDLE AGED; PREDICTION AND FORECASTING; TH1 CELL; TH2 CELL;

FEMALE; GRAFT REJECTION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; TH1 CELLS; TH2 CELLS;

EID: 0033624110     PISSN: 09629351     EISSN: None     Source Type: Journal    
DOI: 10.1080/09629350050024366     Document Type: Article

References (21)

1. 1. Powrie F, Coffman RL. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol Today 1993; 14: 270-274.
2. 2 paradigm and the allograft response. Curr Opin Immunol 1996; 8: 688-693.
3. 3. Imagawa DK, Millis JM, Olthoff KM, Derus LJ, Chia D, Ozawa M, Dempsey RA, Iwaki Y, Levy PJ, et al. The role of tumor necrosis factor in allograft rejection. I. Evidence that elevated levels of tumor necrosis factor-alpha predict rejection following orthotopic liver transplantation. Transplantation 1990; 50: 219-225.
4. 4. Hamilton G, Zommer A, Hofbauer S, Grant FX, Fugger R. Intraoperative course and prognostic significance of endotoxin, tumor necrosis factor-alpha and interleukin-6 in liver transplant recipients. Immunobiology 1991; 182: 425-439.
5. 5. Johnson CP, Choharmonal A, Buchmann E, Roza AM, Adams MB. Plasma IL-2 levels and diagnosis of renal transplant rejection. Transplantation Proc 1990; 22: 1849-1851.
6. 6. Nickerson P, Pacheco-Silva A, O'Connell PJ, Steuer W, Kelley VR, Strom TB. Analysis of cytokine transcripts in pancreatic islet cell allografts during rejection and tolerance induction. Transplantation Proc 1993; 25: 984-985.
7. 7. Mottram PL, Han WR, Purcell LJ, McKenzie IF, Hancock WW. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 1995; 59: 559-565.
8. 8. Waldmann H, Cobbold SP. The use of monoclonal antibodies to achieve immunological tolerance. Immunol Today 1993; 14: 247-251.
9. 9. Chen N, Field EH. Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance. Transplantation 1995; 59: 933-941
10. 10. Kutukculer N, Clark K, Rigg KM, Forsythe JLR, Proud G, Taylor RMR, Shenton BK. The value of posttransplant monitoring of interleukin (IL)-2, IL-3, IL-4, ± L-6, IL-8 and soluble CD23 in the plasma of renal allograft recipients. Transplantation 1995; 59: 333-340.
11. 11. Baan C, Metselaar H, Mol W, Tialnus H, Izermans JI, Zondervan P, Schalm S, Niesters B, Weimar W. Mechanisms leading to graft acceptance after clinical liver transplantation. Hepatology 1996; 24(Suppl): 423A.
12. 12. Senitzer D, Greenstein SM, Louis P, Mallis M, Syrylon N, Glicklich D. Monitoring of serum IL-2R levels in cadaver renal transplants: a prospective blind study. Transplantation Proc 1991; 23: 1279.
13. 13. Young-Fadok TM, Simpson MA, Madras PN, Dempsey RA, O'Connor K, Monaco AP. Predictive value of pretransplant IL-2 levels in kidney transplantation. Transplantation Proc 1991; 23: 1295-1296.
14. 14. Kutukculer N, Shenton BK, Clark K, Rigg KM, Forsythe JL, Kirby JA, Proud G, Taylor RM. Renal allograft rejection: the temporal relationship and predictive value of palsma TNF (alpha and beta) IFN-gamma and soluble ICAM-1. Transplant Int 1995; 8: 45-50.
15. 15. Scoarzec JY, Durand F, Degott C, Delantier D, Berman J, Belghiti J, Benhamon JP, Feldman G. Expression of cytokine-dependent adhesion molecules in post perfusion biopsy specimens of liver allograft. Gastroenterology 1994; 107: 1094-1102.
16. 16. Lang T, Kraus SM, Villanueva JC, Cox K, So S, Martinez OM. Differential patterns of circulating intercellular adhesion molecule-1 (cICAM-1) and vascular cell adhesion molecule-1 (cVCAM-1) during liver allograft rejection. Transplantation 1995; 59: 584-589.
17. 17. Copin MC, Noel C, Hazzan M, Janin A, Pruvot FR, Dessaint JP, Lelievre G, Gosselin B. Diagnostic and predictive value of an immunohistochemical profile in asymptomatic acute rejection of renal allografts. Transplant Immunol 1995; 3 229-239.
18. 18. Steinhoff G, You XM, Steinmuller C, Bauer D, Lohmann-Matthes ML, Bruggeman CA, Haverich A. Enhancement of cytomegalovirus infection and acute rejection after allogeneic lung transplantation in the rat. Transplantation 1996; 61: 1250-1260.
19. 19. Gorczynski RM, Adams RB, Levy GA, Chung SW. Correlation of peripheral blood lymphocyte and intragraft cytokine mRNA expression with rejection in orthotopic liver transplantation. Surgery 1996; 120 496-502.
20. 20. Conti F, Leroy-Viard K, Boulland ML, Gaulard P, Zafrani ES, Houssin D, Calmus Y. Serum level and in situ expression of interleukin-10 during liver allograft rejection in humans. Hepatology 1996; 24(Suppl): 434A.
21. 21. Hadzic N, Hussain M, Cheeseman P, Heaton ND, Rela M, Mieli-Vergani G, Vergani D. T-helper 1 and T-helper 2 cytokine profiles during complications after pediatric liver transplantation. Hepatology 1996; 24(Suppl): 304A.