Selective antagonism of the ET(A) receptor, but not the ET(B) receptor, is protective against ischemic acute renal failure in rats

Japanese Journal of Pharmacology

Volumn 82, Issue 4, 2000, Pages 307-316

  Kuro, Toshihiko ^a   Kohnou, Kaori ^a   Kobayashi, Yutaka ^a   Takaoka, Masanori ^a   Opgenorth, Terry J ^b   Wessale, Jerry L ^b   Matsumura, Yasuo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Acute renal failure; Endothelin 1; ET(A) receptor; ET(B) receptor; Renal function

Indexed keywords

(2ALPHA,3BETA,4ALPHA) 4 (1,3 BENZODIOXOL 5 YL) 1 [2 (2,6 DIETHYLPHENYL)AMINO] 2 OXOETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; ATRASENTAN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; 4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; PYRROLIDINE DERIVATIVE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; KIDNEY ISCHEMIA; KIDNEY TUBULE NECROSIS; MALE; NONHUMAN; RAT; REPERFUSION INJURY; ANIMAL; BLOOD; COMPARATIVE STUDY; DRUG ANTAGONISM; ISCHEMIA; KIDNEY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; ENDOTHELIN-1; ISCHEMIA; KIDNEY; KIDNEY FAILURE, ACUTE; MALE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; REPERFUSION INJURY;

EID: 0033623977     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.82.307     Document Type: Article

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