Distribution of Δ32 alelle of the CCR5 gene in the population of Poland

Journal of Human Genetics

Volumn 45, Issue 5, 2000, Pages 271-274

  Jagodzinski, P P ^a   Lecybyl R ^a   Ignacak, M ^a   Juszczyk, J ^a   Trzeciak, W H ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

CCRS 32 allele; Epidemiology; HIV 1; Provinces of Poland

Indexed keywords

CHEMOKINE RECEPTOR CCR5; PRIMER DNA;

ALLELE; ARTICLE; GENE FREQUENCY; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RESISTANCE; MAJOR CLINICAL STUDY; MIGRATION; POLAND; POPULATION GENETICS; POPULATION RESEARCH; GENETICS; GENOTYPE; NUCLEOTIDE SEQUENCE;

ALLELES; BASE SEQUENCE; DNA PRIMERS; GENETICS, POPULATION; GENOTYPE; HUMANS; POLAND; RECEPTORS, CCR5;

EID: 0033623221     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380070014     Document Type: Article

References (13)

1. CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
2. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals
3. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
4. + cells is mediated by the chemokine receptor CC-CKR-5
5. Heterozy-gosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in cohort of HIV-seropositive individuals
6. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
7. Chemokine receptors and HIV-1: The fusion of two major research fields
8. The delta ccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe
9. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
10. Distribution of the CCR5 gene 32-bp deletion in Europe
11. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure
12. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
13. The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule