Mouse FcγRII is a negative regulator of FcγRIII in IgG immune complex-triggered inflammation but not in autoantibody-induced hemolysis

European Journal of Immunology

Volumn 30, Issue 2, 2000, Pages 481-490

  Schiller, Carsten ^a   Janssen Graalfs, Iska ^a   Baumann, Ulrich ^a   Schwerter Strumpf, Kirsten ^a   Izui, Shozo ^b   Takai, Toshiyuki ^c   Schmidt, Reinhold E ^a   Gessner, J Engelbert ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c NONE

Author keywords

Arthus reaction; Fc receptor II; Fc receptor III; Hemolytic anemia; Knockout

Indexed keywords

AUTOANTIBODY; FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ARTHUS PHENOMENON; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; CONTROLLED STUDY; ERYTHROCYTE; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; HEMOLYTIC ANEMIA; IMMUNOLOGY;

ANEMIA, HEMOLYTIC; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ARTHUS REACTION; AUTOANTIBODIES; DOWN-REGULATION; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN G; MICE; MICE, INBRED C57BL; RECEPTORS, IGG;

EID: 0033622136     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200002)30:2<481::AID-IMMU481>3.0.CO;2-L     Document Type: Article

References (37)

1. Ravetch, J. V. and Kinet, J.-P., Fc receptors. Annu. Rev. Immunol. 1991. 9: 457-492.
2. Hulett, M. D. and Hogarth, P. M., Molecular basis of Fc receptor function. Adv. Immunol. 1994. 57: 1-127.
3. Gessner, J. E., Heiken, H., Tamm, A. and Schmidt, R. E., The IgG Fc receptor family. Ann. Hematol. 1998. 76: 231-248.
4. Daëron, M., Fc receptor biology. Annu. Rev. Immunol. 1997. 15: 203-234.
5. Takai, T., Li, M., Sylvestre, D. L., Clynes, R. and Ravetch, J. V., FcR γ chain deletion results in pleiotropic effector cell defects. Cell 1994. 76: 519-529.
6. Dombrowicz, D., Lin, S., Flamand, V., Brini, A. T., Koller, B. H. and Kinet, J.-P., Allergy-associated FcRß is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity 1998. 8: 517-529.
7. 2+ mobilization is integrated by CD19 dephosphorylation. Immunity 1997. 7: 49-58.
8. Amigorena, S., Bonnerot, C., Drake, J., Choquet, D., Hunziker, W., Guillet, J. G., Webster, P., Sautes, C., Mellman, I. and Fridman, W. H., Cytoplasmic domain heterogeneity and function of IgG Fc receptors in B-lymphocytes. Science 1992. 256: 1808-1812.
9. Daëron, M., Malbec, O., Latour, S., Arock, M. and Fridman, W. H., Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J. Clin. Invest. 1995. 95: 577-585.
10. Daëron, M., Latour, S., Malbec, O., Espinosa, E., Pina, P., Pasmans, S. and Fridman, W. H., The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 1995. 3: 635-646.
11. Takai, T., Ono, M., Hikida, M., Ohmori, H. and Ravetch, J. V., Augmented humoral and anaphylactic responses in FcγRII-deficient mice. Nature 1996. 379: 346-349.
12. Hazenbos, W. L. W., Gessner, J. E., Hofhuis, F. M. A., Kuipers, H., Meyer, D., Heijnen, I. A. F. M., Schmidt, R. E., Sandor, M., Capel, P. J. A., Daëron, M., van de Winkel, J. G. J. and Verbeek, J. S., Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16) deficient mice. Immunity 1996. 5: 181-188.
13. Meyer, D., Schiller, C., Westermann, J., Izui, S., Hazenbos, W. L. W., Verbeek, J. S., Schmidt, R. E. and Gessner, J. E., FcγRIII (CD16) deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia. Blood 1998. 81: 3397-4002.
14. Hazenbos, W. L. W., Heijnen, I. A. F. M., Meyer, D., Hofhuis, F. M. A., Renardel de Lavalette, C., Schmidt, R. E, Capel, P. J. A., van de Winkel, J. G. J., Gessner, J. E., van den Berg, T. K. and Verbeek, J. S., Murine IgG1-complexes trigger immune effector functions predominantly via FcγRIII (CD16). J. Immunol. 1998. 161: 3026-3032.
15. Ono, M., Bolland, S., Tempst, P. and Ravetch, J. V., Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRII. Nature 1996. 383: 263-266.
16. Ujike, A., Ishikawa, Y., Ono, M., Yuasa, T., Yoshino, T., Fukumoto, M., Ravetch, J. V. and Takai, T., Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG. J. Exp. Med. 1999. 189: 1573-1580.
17. Clynes, R., Maizes, J. S., Guinamard, R., Ono, M., Takai, T. and Ravetch, J. V., Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J. Exp. Med. 1999. 189: 179-185.
18. Unkeless, J. C., Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 1979. 142: 580-596.
19. Holmes, K. L., Palfree, R. G. E., Hämmerling, U. and Morse III, H. C., Alleles of the Ly-17 alloantigen define polymorphisms of the murine IgG Fc receptor. Proc. Natl. Acad. Sci. USA 1985. 82: 7706-7710.
20. Lah, M., Quelch, K., Deacon, N. J., McKenzie, I. F. C. and Hogarth, P. M., Identification of the mouse β FcyRII polymorphism by direct sequencing of amplified genomic DNA. Immunogenetics 1990. 31: 202-206.
21. Shibata, T., Berney, T., Reininger, L., Chicheportiche, Y., Ozaki, S., Shirai, T. and Izui, S., Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms. Int. Immunol. 1990. 2: 1133-1141.
22. Gavin, A. L., Hamilton, J. A. and Hogarth, P. M., Extracellular mutations of non-obese diabetic mouse FcγRI modify surface expression and ligand binding. J. Biol. Chem. 1996. 271: 17091-17099.
23. Hunter, S., Indik, Z. K., Kim, M.-K., Cauley, M. D., Park, J.-G. and Schreiber, A. D., Inhibition of Fcγ receptor-mediated phagocytosis by a nonphagocytic Fcγ receptor. Blood 1998. 91: 1762-1768.
24. Ahmed, S. S., Muro, H., Nishimura, M., Kosugi, I., Tsutsui, Y. and Shirasawa, H., Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: a histological analysia using soluble Immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2). Hepatology 1995. 22: 316-324.
25. Miyajima, I., Dombrowicz, D., Martin, T. R., Ravetch, J. V., Kinet, J.-P. and Galli, S. J., Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. J. Clin. Invest. 1997. 99: 901-914.
26. Dombrowicz, D., Flamand, V., Miyajima, I., Ravetch, J. V., Galli, S. J. and Kinet, J.-P., Absence of FcεRI α chain results in upregulation of FcγRIII-dependent mast cell degranulation and anaphylaxis. J. Clin. Invest. 1997. 99: 915-925.
27. Sylvestre, D. L. and Ravetch, J. V., A dominant role for mast cell Fc receptors in the Arthus reaction. Immunity 1996. 5: 387-380.
28. Nieswandt, B., Echtenacher, B., Wachs, F.-P., Schröder, J., Gessner, J. E., Schmidt, R. E., Grau, G. E. and Männel, D. N., Acute systemic reaction and lung alterations induced by an anti-platelet integrin gpII/IIIa antibody in mice. Blood 1999. 94: 684-693.
29. Clynes, R., Dumitru, C. and Ravetch, J. V., Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 1998. 279: 1052-1054.
30. Park, S. Y., Ueda, S., Ohno, H., Hamano, Y., Tanaka, M., Shiratori, T., Yamazaki, T., Arase, H., Arase, N., Karasawa, A., Sato, S., Ledermann, B., Kondo, Y., Okumura, K., Ra, C. and Saito, T., Resistance of Fc receptor-deficient mice to fatal glomerulonephritis. J. Clin. Invest. 1998. 102: 1229-1238.
31. Clynes, R. and Ravetch, J. V., Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity 1995. 3: 31-26.
32. b mice susceptible to collagen-induced arthritis. J. Exp. Med. 1999. 189: 187-194.
33. Clynes, R., Maizes, J. S., Guinamard, R., Ono, M., Takai, T. and Ravetch, J. V., Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J. Exp. Med. 1999. 189: 179-185.
34. Lepay, D. A., Nathan, C. F., Steinman, R. M., Murray, H. W. and Cohn, Z. A., Murine Kupffer cells: mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J. Exp. Med. 1985. 16: 1079-1096.
35. Ding, A. and Nathan, C., Analysis of the nonfunctional respiratory burst in murine Kupffer cells. J. Exp. Med. 1988. 167: 1154-1170.
36. Suzuki, Y., Shirato, I., Okumura, K., Ravetch, J. V., Takai, T., Tomino, Y. and Ra, C., Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis. Kidney Int. 1998. 54: 1166-1174.
37. Kulczycki, A. J., Webber, J., Soares, H. A., Onken, M. D., Thompson, J. A., Chaplin, D. D., Loh, D. Y. and Tillinghast, J. P., Genomic organization of mouse Fcγ receptor genes. Proc. Natl. Acad. Sci. USA 1990. 87: 2856-2860.