Attenueted β-adrenoceptor-mediated cardiac contractile responses following androgenic steroid administration to sedentary rats

European Journal of Applied Physiology

Volumn 81, Issue 4, 2000, Pages 310-316

  Norton, G R ^a   Trifunovic, B ^a   Woodiwiss, A J ^a  

^a UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

Author keywords

Inotropy; Steroids; Adrenoceptor agonist

Indexed keywords

ANDROGEN; ARACHIS OIL; BENZYL ALCOHOL; BETA ADRENERGIC RECEPTOR; ISOPRENALINE; NANDROLONE DECANOATE; ANABOLIC AGENT; CARDIOTONIC AGENT; DRUG DERIVATIVE; NANDROLONE;

ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; HEART CONTRACTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART PERFORMANCE; IN VITRO STUDY; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; ANIMAL EXPERIMENT; DIASTOLE; HEART; HISTOLOGY; MALE; ORGAN SIZE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYSTOLE;

ANABOLIC AGENTS; ANIMALS; CARDIOTONIC AGENTS; DIASTOLE; HEART; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; NANDROLONE; ORGAN SIZE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; SYSTOLE;

EID: 0033621876     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004210050048     Document Type: Article

References (24)

1. Behrendt H, Boffin H (1977) Myocardial cell lesions caused by an anabolic hormone. Cell Tissue Res 181:423-426
2. Brower KJ, Ehopulos GA, Blow FC, Catlin DH, Beresford TP (1990) Evidence for physical and psychological dependence on anabolic androgenic steroids in eight weight lifters Am J Psychiatry 147:510-512
3. Crist DM, Stackpole PJ, Peake GT (1983) Effects of androgenic-anabolic steroids on neuromuscular power and body composition. J Appl Physiol 54:366-370
4. De Piccoli B, Giada F, Benettni A, Sartori F, Piccoli E (1991) Anabolic steroid use in bodybuilders an echocardiographic study of left ventricular morphology and function Int J Sports Med 412:408-412
5. Hoberman JM, Yesalis CE (1995) The history of synthetic testosterone. Sci Am 272-60-65
6. Karhunen K, Ramo P, Kettunen R (1988) Anabolic steroids alter the haemodynamic effects of endurance and deconditioning of rats. Acta Physiol Scand 133 297-306
7. Liang MTC, Paulson DJ, Kepp SJ, Glenek T, Meneses P, Gierke LW, Sekwartz FN (1993) Effects of anabolic steroids and endurance exercise on cardiac performance. Int J Sports Med 14 324-329
8. Luke JL, Farb A, Virmani R, Sample RHB (1990) Sudden cardiac death during exercise in a weight lifter using anabolic androgenic steroids. J Forensic Sci 35:1441-1447
9. McNutt RA, Ferenchick GS, Kirlin PC, Hamlin NJ (1988) Acute myocardial infarction in a 22-year-old world class weight lifter using anabolic steroids Am J Cardiol 62 164
10. Norton GR, Tsotetsi J, Trifunovic B, Hartford C, Candy GP, Woodiwiss AJ (1997) Myocardial stiffness is attributed to alterations in cross-linked collagen rather than total collagen or phenotypes in spontaneously hypertensive rats. Circulation 96:1991-1998
11. 1 receptor-mediated anti-adrenergic effects in the rat myocardium Am J Physiol 276 H341-H349
12. Pearson AC, Schiff M, Mrosek D, Labovitz AJ, Williams GA (1986) Left ventricular diastolic function in weight lifters Am J Cardiol 58:1254-1259
13. Pope HG, Katz DL (1988) Affective and psychotic symptoms associated with anabolic steroid use Am J Psychiatry 145 487-490
14. Ramo P (1987) Anabolic steroids alter the haemodynamic responses of the canine left ventricle. Acta Physiol Scand 130:209-217
15. Remes K, Vuopio P, Jarvanen M, Harkonen M, Aldercreutz H (1977) Effect of short-term treatment with an anabolic steroid (methandienone) and dehydroepiandrosterone sulphate on plasma hormones, red cell volume and 2,3-diphosphoglycerate in athletes Scand J Clin Lab Invest 37 577-586
16. Sagawa K, Maughan L, Suga J, Sunagawa K (1988) Cardiac contraction and the pressure-volume relationship. Oxford University Press, New York, pp 58-70, 367-369
17. Thompson PD, Sadaniantz A, Cullinane EM, Bodziony KS, Catlin DH, Torek-Both G, Douglas PS (1992) Left ventricular function is not impaired in weight-lifters who use anabolic steroids J Am Coll Cardiol 19:278-282
18. Titlestad SD, Lambert MI, Schwellnus MP (1994) A survey to determine types and dosages of anabolic androgenic steroids used by competitive bodybuilders in South Africa. S Aft J Sports Med 1:24-28
19. Trifunovic B, Norton GR, Duffield MJ, Avraam P, Woodiwiss AJ (1995) An androgenic steroid decreases left ventricular compliance in rats. Am J Physiol 258:H1096-H1103
20. Trifunovic B, Woodiwiss AJ, Duffield M, Norton M, Norton GR (1998) Novel attributes of an androgenic steroid-mediated increase in cardiac end diastolic stiffness in rats. Can J Physiol Pharmacol 76:1-8
21. Urhausen A, Holpes R, Kindermann W (1989) One-and two-dimensional echocardiography in bodybuilders using anabolic steroids. Eur J Appl Physiol 58 633-640
22. Weber KT, Janicki J, Schroff SG, Pick R, Chen RM, Abrahams G, Bashey RI (1988) Collagen remodelling of the pressure-overloaded hypertrophied non-human primate myocardium. Circ Res 62 757-765
23. Woodiwiss AJ, Norton GR (1995) Exercise-induced cardiac hypertrophy is associated with an increased myocardial compliance. J Appl Physiol 78 1303-1311
24. Yu-Yahiro JA, Michael RH, Nasrallah DV, Schofield B (1989) Morphologic and histologic abnormalities in female and male rats treated with anabolic steroids. Am J Sports Med 17:686-689