Topical prostaglandin E2 protects isolated gastric mucosa against acidified taurocholate-, but not ethanol- or aspirin-induced injury

Digestive Diseases and Sciences

Volumn 45, Issue 1, 2000, Pages 99-104

  Ranta Knuuttila, Tuula ^a   Mustonen, Harri ^a   Kivilaakso, Eero ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

ASA; Ethanol; Gastric mucosa; Gastric mucosal injury; Intracellular pH; PGE2; Taurocholate

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; PROSTAGLANDIN E2; TAUROCHOLIC ACID; 16,16 DIMETHYLPROSTAGLANDIN E2;

AMPHIBIA; ANIMAL EXPERIMENT; ARTICLE; CELL PH; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; STOMACH DISEASE; STOMACH MUCOSA; ANIMAL; NECTURUS; PH; TOPICAL DRUG ADMINISTRATION;

16,16-DIMETHYLPROSTAGLANDIN E2; ADMINISTRATION, TOPICAL; ANIMALS; ASPIRIN; ETHANOL; GASTRIC MUCOSA; HYDROGEN-ION CONCENTRATION; NECTURUS MACULOSUS; TAUROCHOLIC ACID;

EID: 0033621816     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005465528158     Document Type: Article

References (34)

1. 1. Robert A: Cytoprotection by prostaglandins. Gastroenterology 77(4 Pt 1):761-767, 1979
2. 2. Miller TA: Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 245(5 Pt 1):G601-G623, 1983
3. 3. Wallace JL: Prostaglandins, NSAIDs, and cytoprotection. Gastroenterol Clin North Am 21(3):631-641, 1992
4. 4. McQueen S, Hutton D, Allen A, Garner A: Gastric and duodenal surface mucus gel thickness in rat: effects of prostaglandins and damaging agents. Am J Physiol 245(3):G388-G393, 1983
5. 2. Am J Physiol 239(1):G44-G48, 1980
6. 2 on the surface hydrophobicity of aspirin-treated canine gastric mucosa. Gastroenterology 88(1 Pt 2):308-314, 1985
7. 2 on gastric blood flow in dogs. Am J Physiol 238(6):G514-G519, 1980
8. 8. Ranta-Knuuttila T, Kiviluoto T, Hyvärinen H, Lehtola A, Kivilaakso E: Prostaglandin protection against hemorrhage-induced gastric stress ulceration in the rat. Dig Dis Sci 34(7):1028-1034, 1989
9. 9. Reimann HJ, Lewin J, Schmidt U, Wendt P, Blueml G, Dajani EZ: Misoprostol prevents damage to the gastric mucosa by stabilizing the mast cells. Prostaglandins 33(suppl): 105-116, 1987
10. 2 on lysosomal membrane stability in rat stomach. J Gastroenterol 29(6):703-709, 1994
11. 1 analogue during initial period of experimental gastric ulcer reverses increase in future ulcer relapse caused by indomethacin. Gastroenterology 106:A41, 1994
12. 12. Gryglewski RJ, Szczeklik A, Wandzilak M: The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl-leucyl-phenylalanine. Biochem Pharmacol 36(24):4209-4213, 1987
13. 2 or sodium thiosulfate. Gastroenterology 91(6):1415-1426, 1986
14. 14. Henagan JM, Schmidt KL, Miller TA: Prostaglandin prevents aspirin injury in the canine stomach under in vivo but not in vitro conditions. Gastroenterology 97(3):649-659, 1989
15. 15. Saario I, Rosen S, Carter K, Silen W: Effect of ethanol on frog gastric mucosa. Electrophysiologic and morphologic correlations. Gastroenterology 94(3):638-646, 1988
16. 16. Arakawa T, Nakamura A, Fukuda T, Satoh H, Kobayashi K: Protection of isolated rat gastric cells by prostaglandins from damage caused by ethanol. Preliminary report. J Clin Gastroenterol 10(suppl 1):S28-S34, 1988
17. 17. Cherner JA, Naik L, Tarnawski A, Brzozowski T, Stachura J, Singh G: Ability of prostaglandin to reduce ethanol injury to dispersed chief cells from guinea pig stomach. Am J Physiol 256(4 Pt 1):G704-G714, 1989
18. 2 on aspirin induced damage to rat gastric epithelial cells in tissue culture. Gut 25(1): 19-25, 1984
19. 2 directly protects isolated rat gastric surface cell membranes against bile salts. Biochim Biophys Acta 902(2):217-222, 1987
20. 20. Terano A, Ota S, Mach T, Hiraishi H, Stachura J, Tarnawski A, Ivey KJ: Prostaglandin protects against taurocholate-induced damage to rat gastric mucosal cell culture. Gastroenterology 92(3):669-677, 1987
21. 21. Kiviluoto T, Mustonen H, Kivilaakso E: Effect of barrier-breaking agents on intracellular pH and epithelial membrane resistances: Studies in isolated Necturus antral mucosa exposed to luminal acid. Gastroenterology 96:1410-1418, 1989
22. 3 layer protects against intracellular acidosis in acid-exposed gastric mucosa. Am J Physiol 264(1 Pt 1):G57-G63, 1993
23. 23. Mustonen H, Kivilaakso E: Luminal acid increases apical cell membrane resistance in isolated Necturus antral mucosa. Gastroenterology 113(3):875-883, 1997
24. 24. Duane WC, Wiegand DM: Mechanism by which bile salt disrupts the gastric mucosal barrier in the dog. J Clin Invest 66(5):1044-1049, 1980
25. 25. Ritehie WJ: Bile acids, the "barrier," and reflux-related clinical disorders of the gastric mucosa. Surgery 82(2):192-200, 1977
26. 26. Miura S, Fukumura D, Shiozaki H, Suzuki M, Kurose I, Suematsu M, et al: Bile acid-induced depolarization of mitochondrial membrane potential preceding cell injury in cultured gastric mucosal cells. J Gastroenterol Heputol 10(6):621-626, 1995
27. 27. Bailey RE, Levine RA, Nandi J, Schwartzel EH Jr, Beach DH, Borer PN, Levy GC: Effects of ethanol on gastric epithelial cell phospholipid dynamics and cellular function. Am J Physiol 252(2 Pt 1):G237-G243, 1987
28. 28. Guth PH: Gastric blood flow in ethanol injury and prostaglandin cytoprotection. Scand J Gastroenterol Suppl 125:86-91, 1986
29. 29. Lacy ER, Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 83(3):619-625, 1982
30. 30. Sato Y, Asaka M, Takeda H, Ohtaki T, Miyazaki T: The mechanisms of aspirin-induced gastric mucosal injury. J Clin Gastroenterol 17(suppl 1):S1-S4, 1993
31. 31. Kao YC, Goddard PJ, Lichtenberger LM: Morphological effects of aspirin and prostaglandin on the canine gastric mucosal surface. Analysis with a phospholipid-selective cytochemical stain. Gastroenterology 98(3):592-606, 1990
32. 32. McCormack K, Brune K: Classical absorption theory and the development of gastric mucosal damage associated with the non-steroidal anti-inflammatory drugs. Arch Toxicol 60(4):261-269, 1987
33. 33. Zhao DL, Hirst BH: Bile salt-induced increases in duodenal brush-border membrane proton permeability, fluidity, and fragility. Dig Dis Sci 35(5):589-595, 1990
34. 34. Zhao D, Hirst BH: Prostaglandin protects against bile salt induced increases in proton permeation of duodenal brush border membrane. Gut 32(6):645-648, 1991