Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: Mechanism of action

Chemistry and Physics of Lipids

Volumn 104, Issue 1, 2000, Pages 1-11

  Sharma, Chandeshwar ^a   Smith, Todd ^a   Li, Shengrong ^b   Schroepfer Jr , George J ^b   Needleman, Dolores H ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

3H Ryanodine binding; Calcium release channel; Dihydrosphingosine; N,N dimethylsphingosine; Phytosphingosine; Sarcoplasmic reticulum

Indexed keywords

CALCIUM CHANNEL; N HEXANOYLSPHINGOSINE; N OCTANOYLSPHINGOSINE; N OLEOYLSPHINGOSINE; N PALMITOYLSPHINGOSINE; N,N DIMETHYLSPHINGOSINE; PHYTOSPHINGOSINE; PHYTOSPHINGOSINE 1 PHOSPHATE; RYANODINE; RYANODINE RECEPTOR; SPHINGANINE; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE DERIVATIVE; UNCLASSIFIED DRUG; CALCIUM CHANNEL BLOCKING AGENT; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; N,N-DIMETHYLSPHINGOSINE; SAFINGOL; SPHINGOSINE 1-PHOSPHATE;

ANIMAL TISSUE; ARTICLE; ARTIFICIAL MEMBRANE; CELL MEMBRANE; CONTROLLED STUDY; HEART MUSCLE; IN VITRO STUDY; ISOTOPE LABELING; LIPID BILAYER; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR BINDING; SARCOPLASMIC RETICULUM; ANIMAL; DRUG EFFECT; KINETICS; METABOLISM; SKELETAL MUSCLE;

ORYCTOLAGUS CUNICULUS;

ANIMALS; CALCIUM CHANNEL BLOCKERS; KINETICS; LIPID BILAYERS; LYSOPHOSPHOLIPIDS; MUSCLE, SKELETAL; MYOCARDIUM; RABBITS; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SPHINGOLIPIDS; SPHINGOSINE;

EID: 0033621735     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(99)00106-1     Document Type: Article

References (49)

1. Ariga T., Jarvis W.D., Yu R.K. Role of sphingolipid-mediated cell death in neurodegenerative diseases. J. Lipid Res. 39:1998;1-16.
2. Betto R., Teresi A., Turcato F., Salviati G., Sabbadini R.A., Krown K., Glembotski C.C., Kindman L.A., Dettbarn C., Pereons Y., Yasui K., Palade P.T. Sphingosylphosphorylcholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes. Biochem. J. 322:1997;327-333.
3. Dahiya R., Ahlawat R.S., Sharma A. The glycosphingolipid composition and glycosyltransferase activities of the small intestinal mucosa of testerone-treated rats. Biochem. Cell Biol. 67:1989;42-47.
4. Dahiya R., Sharma A., Narayan P. Effect of testosterone on the glycosphingolipid compositon of rat kidney. Biochim. Biophys. Acta. 49:1990;1195-1201.
5. Dettbarn C.A., Betto R., Salviati G., Palade P., Jenkins G.M., Sabbadini R.A. Modulation of cardiac sarcoplasmic reticulum ryanodine receptor by sphingosine. J. Mol. Cell. Cardiol. 26:1994;229-242.
6. Ghosh T.K., Bian J., Gill D.L. Sphingosine-1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J. Biol. Chem. 269:1994;22628-22635.
7. Ghosh T.K., Bian J., Gill D.L. Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science. 248:1990;1653-1656.
8. 2+ from the sarcoplasmic reticulum. McCormack J.G., Cobbold R.H. Cellular Calcium. 1991;313-343 IRL Press, Oxford.
9. 3H]ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes. Anal. Biochem. 183:1989;31-41.
10. Hannun Y.A., Bell R.M. Function of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 243:1989;500-507.
11. Hannun Y.A., Linardie C.M. Sphingolipid breakdown products, anti-proliferative and tumor-suppressor lipids. Biochim. Biophys. Acta. 1154:1993;223-226.
12. Hara A., Taketomi T. Characterization and change of phospholipids in the aorta of Watanable hereditable hyperlipidemic rabbits. Jpn. J. Exp. Med. 60:1990;311-318.
13. 2+ release channel in malignant hyperthermia. J. Biol. Chem. 267:1992;6702-6709.
14. Hulme E.C. Receptor-Ligand Interactions: a Practical Approach. 1992;IRL Press, Oxford.
15. Igarashi Y., Kitamura K., Toyokuni T., Dean B., Fenderson B., Ogawa T., Hakomori S. A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. J. Biol. Chem. 265:1990;5385-5389.
16. 2+ permeable channel. J. Biol. Chem. 270:1995;5266-5269.
17. 2+ permeable channel from rat basophilic leukemia cells. J. Biol. Chem. 269:1994;13088-13091.
18. 13C nuclear magnetic resonance assignments for D-erythro-sphingosine. J. Lipid Res. 36, 787-803.
19. Lester R.L., Dickson R.C. Sphingolipids with inositolphosphate-containing head groups. Adv. Lipid Res. 26:1993;253-271.
20. Li, S., Wilson, W.K., Schroepfer, G.J., Jr., 1999. Chemical synthesis of D-ribo-sphingosine-1-phosphate, a potential modulator of cellular processes. J. Lipid Res. 40, 117-125.
21. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
22. 2+ release-mediating protein from endoplasmic reticulum. Proc. Natl. Acad. Sci. USA. 93:1996;1993-1996.
23. Merrill, A.H., Jr., Schmelz, E.M., Dillehay, D.L., Spiegel, S., Shayman, J.A., Schroeder, J.J., Riley, R.T., Voss, K.A., Wang, E., 1997. Sphingolipids - the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol. Appl. Pharmacol. 142, 208-225.
24. Merrill, A.H., Jr., Wang, E., Vales, T.R., Smith, E.R., Schroeder, J.J., Menaldino, D.S., Alexander, C., Crane, H.M., Xia, J., Liotta, D.C., Meredith, F.I., Riley, R.T., 1996. Fumonisin toxicity and sphingolipid biosynthesis. In: L. Jackson (Ed.), Fumonisins in Food. Plenum Press, New York, pp. 297-306.
25. Mikami M., Tuhazaki K., Nozawa S., Iwamori M., Nagai Y. Menstrual cycle-associated expression of 2-hydroxy fatty acyl phytosphingosine containing GlyCer, LacCer and Gb3Cer in human uterine endometrium. Biochim. Biophys. Acta. 1125:1992;104-109.
26. 2+ release channel activity by sphingosine. Am. J. Physiol. 272, C1465-C1474.
27. Oral, H., Dorn, G.W., Jr., Mann, D.L., 1997. Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha. J. Biol. Chem. 272, 4836-4842.
28. Pinkerton, F.D., Kisic, A., Wilson, W.K., Schroepfer, G.J., Jr., 1990. D-Erythro-sphingosine lowers 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 190, 63-69.
29. Reibel D.K., O'Rourke B., Foster K.A., Hutchinson H., Uboh C.E., Kent R.L. Altered phospholipid metabolism in pressure-overload hypertrophied hearts. Am. J. Physiol. 250:1986;H1-H6.
30. Rosemblatt M., Hidalgo C., Vergara C., Ikemoto N. Immunological and biochemical properties of transverse tubule membranes isolated from rabbit skeletal muscle. J. Biol. Chem. 256:1981;8140-8148.
31. Sabbadini R., McNutt W., Jenkins G., Betto R., Salviati G. Sphingosine is endogenous to cardiac and skeletal muscle. Biochem. Biophys. Res. Commun. 193:1993;752-758.
32. Sabbadini R.A., Betto R., Teresi A., Fachechi-Cassano G., Salviati G. The effects of sphingosine on sarcoplasmic reticulum membrane calcium release. J. Biol. Chem. 267:1992;15475-15484.
33. Sitsapesan R., Williams A.J. Mechanisms of caffeine activation of single channel calcium release channels of sheep cardiac sarcoplasmic reticulum. J. Physiol. 423:1990;425-439.
34. Spiegel S., Olivera A., Carlson R.O. The role of sphingosine in cell growth regulation and transmembrane signaling. Adv. Lipid Res. 25:1993a;105-129.
35. Spiegel S., Olivera A., Carlson R.O. The role of sphingosine in cell growth regulation and transmembrane signaling. Adv. Lipid Res. 25:1993b;105-129.
36. Titievsky A., Titievskaya I., Pasternack M., Kaila K., Tornquist K. Sphingosine inhibits voltage-operated calcium channels in GH4C1 cells. J. Biol. Chem. 273:1998;242-247.
37. Valsecchi M., Chigorno V., Nicolini M., Sonnino S. Changes of free long-chain bases in neuronal cells during differetiation and aging in culture. J. Neurochem. 67:1996;1866-1871.
38. van Koppen C.J., Meyer zu Heringdorf D., Laser K.T., Zhang C., Jakobs K.H., Bunnemann M., Pott L. Activation of high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J. Biol. Chem. 271:1998;2082-2087.
39. Vorbeck M.L., Malewski E.F., Erhart L.S., Martin A.P. Membrane phospholipid metabolism in the isoproterenol-induced cardiomyopathy of the rat. Rec. Adv. Stud. Cardiac Struct. Metab. 6:1975;175-181.
40. Wang C.T., Schick P.K. The effect of thrombin on the organization of human platelet membrane glycosphingolipids. The sphingosine composition of platelet glycolipids and ceramides. J. Biol. Chem. 256:1981;752-756.
41. 2+ release channel. J. Biol. Chem. 268:1993;20974-20982.
42. 2+ release channel from skeletal muscle sarcoplasmic reticulum. J. Biol. Chem. 271:1996;8387-8393.
43. Webster R.J., Sabbadini R.A., Dettbarn C.A., Paolin P.J. Sphingosine effects on the contractile behavior of skinned cardiac myocytes. J. Mol. Cell. Cardiol. 26:1994;1273-1290.
44. Wertz P.W., Downing D.T. Free sphingosine in human epidermis. J. Invest. Dermatol. 94:1990;159-161.
45. Williams A.J. Ion conduction and discrimination in the sarcoplasmic reticulum ryanodine receptor/calcium-release channel. J. Muscle Res. Cell Motil. 13:1992;7-26.
46. Yasui K., Palade P. Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes. Am. J. Physiol. 39:1996;C645-C649.
47. Yatomi Y., Igarashi Y., Yang L., Hisano N., Qi R., Asazuma N., Satoh K., Ozaki Y., Kume S. Sphingosine-1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J. Biochem. 12:1997;969-973.
48. Yatomi Y., Ozaki Y., Satoh K., Kume S., Ruan F., Igarashi Y. N,N-dimethylsphingosine phosphorylation in human platelets. Biochem. Biophys. Res. Commun. 231:1997;848-851.
49. Yatomi Y., Ruan F., Megidish T., Toyokuni T., Hakomori S., Igarashi Y. N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry. 35:1996;626-633.