Kinase-dependent change in the conformation of the leukocyte NADPH oxidase subunit p47phox

Molecules and Cells

Volumn 9, Issue 6, 1999, Pages 652-656

  Park, Jeen Woo ^a   Park, Hee Sae ^a   Chang, Young Moo ^a  

^a Kyungpook National University   (South Korea)

Author keywords

Conformational Change; Kinases; NADPH Oxidase; Neutrophil

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; N ETHYLMALEIMIDE; NEUTROPHIL CYTOSOLIC FACTOR 1; PHOSPHOPROTEIN; PROTEIN KINASE C; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRYPTOPHAN;

ARTICLE; CHEMISTRY; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HUMAN; LEUKOCYTE ACTIVATION; METABOLISM; MUTATION; NEUTROPHIL; PHOSPHORYLATION; PROTEIN CONFORMATION; SPECTROFLUOROMETRY;

CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ETHYLMALEIMIDE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NADPH OXIDASE; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN KINASE C; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 0033621299     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Babior, B. M. (1992) The respiratory burst oxidase. Adv. Enzymol. Areas Mol. Biol. 65, 49-95.
2. Clark, R. A., Leidal, K. G., Pearson, D. W., and Nauseef, W. M. (1987) NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system. J. Biol. Chem. 262, 4065-4074.
3. Clark, R. A., Volpp, B. D., Leidal, K. G., and Nauseef, W. M. (1990) Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation. J. Clin. Invest. 85, 714-721.
4. de Mendez, I., Adams, A. G., Sokolic, R. A., Malech, H. L., and Leto, T. L. (1996) Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells. EMBO J. 15, 1211-1220.
5. phox during neutrophil activation. J. Biol. Chem. 269, 23413-23436.
6. phox by p38 and ERK but not by JNK. Arch. Biochem. Biophys. 334, 395-400.
7. phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase. J. Biol. Chem. 271, 6374-6378.
8. phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis. J. Clin. Invest. 96, 1499-1505.
9. Fuchs, A., Dagher, M.-C., and Vignais, P. V. (1995) Mapping the domains of interaction of p40-phox with both p41-phox and p61-phox of the neutrophil oxidase complex using the two-hybrid system. J. Biol. Chem. 270, 5695-5697.
10. Hayakawa, T., Suzuki, K., Suzuki, S., Andrews, P. C., and Babior, B. M. (1986) A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease. J. Biol. Chem. 261, 9109-9115.
11. 558. J. Clin. Invest. 87, 352-356.
12. Knaus, U. G., Heyworth, P. G., Evans, T., Curnutte, J. T., and Bokoch, G. M. (1991) Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254, 1512-1515.
13. Knaus, U. G., Heyworth, P. G., Kinsella, B. T., Curnutte, J. T., and Bokoch, G. M. (1992) Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J. Biol. Chem. 267, 23575-23582.
14. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
15. phox during activation studied through its intrinsic fluorescence. Biochim. Biophys. Acta 1387, 406-414.
16. phox. Biochem. Biophys. Res. Commun. 259, 38-42.
17. phox membrane translocation as the inhibitory mechanism of S-nitrosothiol on the respiratory burst oxidase in human neutrophils. Biochem. Biophys. Res. Commun. 220, 31-35.
18. phox cytosolic component of the phagocyte oxidase by in vitro phosphorylation. Biochem. Biophys. Res. Commun. 211, 410-416.
19. phox. Biochemistry 36, 7474-7480.
20. Park, J.-W., Ma, M., Ruedi, J. M., Smith, R. M., and Babior, B. M. (1992) The cytosolic components of the respiratory burst oxidase exist as a Mr ∼240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free system. J. Biol. Chem. 267, 17327-17332.
21. Park, J.-W., El Benna, J., Scott, K. E., Christensen, B. L., Chanock, S. J., and Babior, B. M. (1994) Isolation of a complex of respiratory burst oxidase components from resting neutrophil cytosol. Biochemistry 33, 2907-2911.
22. phox during oxidase activation. J. Biol. Chem. 272, 11035-11043.
23. Quinn, M. T., Evans, T., Loetterle, L. R., Jesaitis, A. J., and Bokoch, B. M. (1993) Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J. Biol. Chem. 268, 20983-20987.
24. Sumitomo, H., Kage, Y., Nunoi, H., Sasaki, H., Nose, T., Fukumaki, Y., Ohno, M., Minakami, S., and Takeshige, K. (1994) Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase. Proc. Natl. Acad. Sci. USA 91, 5345-5349.
25. phox using tryptophan fluorescence spectroscopy. J. Biol. Chem. 272, 29502-29510.
26. Tyagi, S. R., Olson, S. C., Burnham, D. N., and Lambeth, J. D. (1991) Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation. J. Biol. Chem. 266, 3498-3504.
27. phox, a component of the neutrophil NADPH oxidase: Effects of guanine 5′-O-(3-thiotriphosphate), diacylglycerol, and an anionic amphiphile. Biochemistry 31, 2765-2774.