Effective Immunotherapy of Cancer by DNA Vaccination

Molecules and Cells

Volumn 9, Issue 4, 1999, Pages 384-391

  Park, Joo Hung ^a   Kim, Chong Jin ^a   Lee, Jung Hee ^a   Shin, Sung Hye ^b   Chung, Gook Hyun ^c   Jang, Yong Suk ^c  

^a Changwon National University   (South Korea)

^b Presbyterian Medical Center   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

Cancer Therapy; DNA Vaccine; MAGE

Indexed keywords

CANCER VACCINE; DNA VACCINE; MAGEA1 PROTEIN, HUMAN; MAGEB1 PROTEIN, MOUSE; RECOMBINANT PROTEIN; TUMOR ANTIGEN; TUMOR PROTEIN; VIRUS DNA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL LINE; CYTOTOXIC T LYMPHOCYTE; FIBROBLAST; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; NEOPLASM; PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; CELL LINE, TRANSFORMED; DNA, VIRAL; FIBROBLASTS; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOPLASMS; PLASMIDS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; VACCINES, DNA;

EID: 0033620958     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Boel, P., Wildmann, C., Sensi, M. L., Brasseur, R., Renauld, J. C., Coulie, P., Boon, T., and van der Bruggen, P. (1995) BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T-lymphocytes. Immunity 2, 167-175.
2. Chen, Y.-T., Stockert, F., Chen, Y., Garin-Chesa, P., Rettig, W. J., van der Bruggen, P., Boon, T., and Old, L. J. (1994) Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies. Proc. Natl. Acad. Sci. USA 91, 1004-1008.
3. Conry, R. M., LoBuglio, A. F., Loechel, F., Moore, S. E., Sumeral, L. A., Barlow, D. L., and Curiel, D. T. (1995) A carcinoembryogenic antigen polynucleotide vaccine has in vivo and in vitro antitumor activity. Gene Ther. 2, 59-65.
4. + T-cell responses: The alternative approaches. Annu. Rev. Immunol. 15, 297-322.
5. De Plaen, E., Arden, K., Traversari, C., Gaforio, J. J., Szikora, J.-P., De Smet, C., Brasseur, F., van der Bruggen, P., Lethe, B., Lurquin, C., Brasseur, R., Chomez, P., De Backer, O., Cavenee, W., and Boon, T. (1994) Structure, chromosomal localization, and expression of 12 genes of the MAGE family. Immunogenetics 40, 360-369.
6. De Smet, C., Lurquin, C., van der Bruggen, P., De Plaen, E., Brasseur, F., and Boon, T. (1994) Sequence and expression pattern of human MAGE-2 gene. Immunogenetics 39, 121-129.
7. Doe, B., Selby, M., Barnett, S., Baenziger, J., and Walker, C. M. (1996) Induction of cytotoxic T-lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc. Natl. Acad. Sci. USA 93, 8578-8583.
8. Donnelly, J. J., Ulmer, J. B., Shiver, J. W., and Liu, M. A. (1997) DNA vaccines. Annu. Rev. Immunol. 15, 617-648.
9. Elliot, B. E., Carlow, D. A., Rodricks, M., and Wade, A. (1989) Perspectives on the role of MHC antigens in normal and malignant cell development. Adv. Cancer Res. 53, 181-244.
10. Fynan, E. F., Webster, R. G., Fuller, D. H., Haynes, J. R., Santoro, J. C., and Robinson, H. L. (1993) DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90, 11478-11482.
11. Gaugler, B., Van den Eynde, B., van der Bruggen, P., Romero, P. Gaforio, J. J., De Plaen, E., Lethe, B., Brasseur, F., and Boon, T. (1994) Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. J. Exp. Med. 179, 921-930.
12. Harding, C. V. and Song, R. (1994) Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules. J. Immunol. 153, 4925-4933.
13. 2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements. J. Biol. Chem. 264, 18083-18090.
14. Hoon, D. S. B., Yuzuki, D., Hayashida, M., and Morton, D. L. (1995) Melanoma patients immunized with cell vaccine induce antibody responses to recombinant MAGE-1 antigen. J. Immunol. 154, 730-737.
15. Houghton, A. N. (1994) Cancer antigens: Immune recognition of self and altered self. J. Exp. Med. 180, 1-4.
16. Hu, X., Chakraborty, N. G., Sporn, J. R., Kurtzman, S. H., Ergin, M. T., and Mukherji, B. (1996) Enhancement of cytolytic T-lymphocyte precursor frequency in melanoma patients following immunization with the MAGE-1 peptide loaded antigen presenting cell-based vaccine. Cancer Res. 56, 2479-2483.
17. Imai, Y., Shichijo, S., Yamada, A., Katayama, T., Yano, H., and Itoh, K. (1995) Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens. Gene 160, 287-290.
18. June, C. H., Ledbetter, J. A., Linsley, P. S., and Thompson, C. B. (1990) Role of the CD28 receptor in T-cell activation. Immunol. Today 11, 211-216.
19. Kocher, T., Schultz-Thater, E., Gudat, F., Schaefer, C., Casorati, G., Juretic, A., Willimann, T., Harder, F., Heberer, M., and Spagnoli, G. C. (1995) Identification and intracellular location of MAGE-3 gene product. Cancer Res. 55, 2236-2239.
20. Lucas, S., De Smet, C., Arden, K. C., Viars, C. S , Lethe, B., Lurquin, C., and Boon, T. (1998) Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. Cancer Res. 58, 743-752.
21. Lurquin, C., De Smet, C., Brasseur, F., Muscatelli, F., Martelange, V., De Plaen, E., Brasseur, R., Monaco, A. P., and Boon, T. (1997) Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. Genomics 46, 397-408.
22. Okamoto, T., Kaneda, Y., Yuzuki, D., Huang, S. K., Chi, D. D., and Hoon, D. S. (1997) Induction of antibody response to humor tumor antigens by gene therapy using a fusigenic viral liposome vaccine. Gene Ther. 4, 969-976.
23. Park, J.-H., Chang, S.-H., Lee, K.-M., and Lee, H.-G. (1995) Murine sarcoma cell transfected with interleukin 12 are rejected in vivo inducing protective and curative immune responses against the parental cells. Mol. Cells 5, 595-604.
24. Park, J.-H. and Shin, S.-H. (1996) Induction of IL-12 gene expression in the brain in septic shock. Biochem. Biophys. Res. Commun. 224, 391-396.
25. Raz, E., Carson, D. A., Parker, S. E., Parr, T. B., Abai, A. M., Aichinger, G., Gromkowski, S. H., Singh, M., Lew, D., Yankauckas, M. A., Baird, S. M., and Rhodes, G. H. (1994) Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular-immunity to viruses. Proc. Natl. Acad. Sci. USA 91, 9519-9523.
26. Raz, E., Tighe, H., Sato, Y., Corr, M., Dudler, J. A., Roman, M., Swain, S., Spigelberg, H. L., and Carson, D. A. (1996) Preferential induction of a ThI immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc. Natl. Acad. Sci. USA 93, 5141-5145.
27. Rosenberg, S. A. (1995) The development of new cancer therapies based on the molecular identification of cancer regression antigens. Cancer J. Sci. Am. 1, 90.
28. Rosenberg, S. A. (1997) Cancer vaccines based on the identification of genes encoding cancer regression antigens. Immunol. Today 18, 175-182.
29. Roszman, T., Elliott, L., and Brooks, W. (1991) Modulation of T-cell function by gliomas. Immunol. Today 12, 370-374.
30. Schmidt-Zachmann, M. S., Hugle-Dorr, B., and Franke, W. W. (1987) A constitutive nucleolar protein identified as a member of the nucleoplasmin family. EMBO J. 6, 1881-1890.
31. Schultz-Thater, E., Juretic, A., Dellabona, P., Luscher, U., Siegrist, W., Harder, F., Heberer, M., Zuber, M., and Spagnoli, G. C. (1994) MAGE-1 gene product is a cytoplasmic protein. Int. J. Cancer 59, 435-439.
32. Shen, Z., Reznikoff, S. Z., Dranoff, G., and Rock, K. L. (1997) Cloned dendritic cells can present exogenous antigens on both MHC class I and II molecules. J. Immunol. 158, 2723-2730.
33. Sobol, R. E., Shawler, D., Dorigo, O., Gold, D., Royston, I., and Fakhari, H. (1995) Gene therapy for carcinoma of the breast; in The Internet Book of Gene Therapy, Sobol, R. E. and Scanlon, K. J. (eds.), pp. 247-255, Stamford: Appleton & Lange, Stamford, USA.
34. Ulmer, J. B., Donnelly, J. J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V. J., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., Hawe, L. A., Leander, K. R., Martinez, D., Perry, H. C., Shiver, J. W., Montgomery, D. L., and Liu, M. A. (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-1749.
35. van der Bruggen, P., Traversari, C., Chomez, P., Lurquin, C., De Plaen, E., van den Eynde, B., Knuth, A., and Boon, T. (1991) A gene encoding an antigen recognized by cytolytic T-lymphocytes on a human melanoma. Science 254, 1643-1647.
36. Wang, B., Boyer, J., Srikantan, V., Coney, L., Carrano, R., Phan, C., Merva, M., Dang, K., Agadjanan, M., Gilbert, L., Ugen, K. E., Williams, W. V., and Weiner, D. B. (1993) DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and nonhuman primates DNA Cell Biol. 12, 799-805.
37. Wang, B., Merva, M., Dang, K., Ugen., K. E., Williams, W. V., and Weiner, D. B. (1995) Immunization by direct DNA inoculation induces rejection of tumor cell challenge. Human Gene Therapy 6, 407-418.
38. Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., and Feigne, P. L. (1990) Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468.